A membrane-permeant, bioactivatable derivative of Ins(1,3,4)P3 and its effect on Cl--secretion from T84 cells

Marco T. Rudolf, Alexis E. Traynor-Kaplan, Carsten Schultz

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The synthesis of rac-2,5,6-tri-O-butyryl-myo-inositol 1,3,4- trisphosphate hexakis(acetoxymethyl) ester [Bt3-Ins(1,3,4)P3/AM, 1], a membrane-permeant derivative of myo-inositol 1,3,4-trisphosphate [Ins(1,3,4)P3] is reported. 1 inhibited calcium-mediated chloride secretion of T84 cells, suggesting a regulatory link of Ins(1,3,4)P3 and the biosynthesis of the known inhibitor myo-inositol 3,4,5,6-tetrakisphosphate.

Original languageEnglish (US)
Pages (from-to)1857-1860
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume8
Issue number14
DOIs
StatePublished - Jul 21 1998
Externally publishedYes

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Derivatives
Membranes
Calcium Chloride
Calcium chloride
Biosynthesis
Esters
inositol 1,3,4-trisphosphate
inositol-3,4,5,6-tetrakisphosphate

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

A membrane-permeant, bioactivatable derivative of Ins(1,3,4)P3 and its effect on Cl--secretion from T84 cells. / Rudolf, Marco T.; Traynor-Kaplan, Alexis E.; Schultz, Carsten.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 8, No. 14, 21.07.1998, p. 1857-1860.

Research output: Contribution to journalArticle

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