A membrane-permeant, bioactivatable derivative of Ins(1,3,4)P3 and its effect on Cl--secretion from T84 cells

Marco T. Rudolf; Alexis E. Traynor-Kaplan; Carsten Schultz

doi:10.1016/S0960-894X(98)00322-9

A membrane-permeant, bioactivatable derivative of Ins(1,3,4)P₃ and its effect on Cl^--secretion from T₈₄ cells

Marco T. Rudolf, Alexis E. Traynor-Kaplan, Carsten Schultz

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The synthesis of rac-2,5,6-tri-O-butyryl-myo-inositol 1,3,4- trisphosphate hexakis(acetoxymethyl) ester [Bt₃-Ins(1,3,4)P₃/AM, 1], a membrane-permeant derivative of myo-inositol 1,3,4-trisphosphate [Ins(1,3,4)P₃] is reported. 1 inhibited calcium-mediated chloride secretion of T₈₄ cells, suggesting a regulatory link of Ins(1,3,4)P₃ and the biosynthesis of the known inhibitor myo-inositol 3,4,5,6-tetrakisphosphate.

Original language	English (US)
Pages (from-to)	1857-1860
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	8
Issue number	14
DOIs	https://doi.org/10.1016/S0960-894X(98)00322-9
State	Published - Jul 21 1998
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(98)00322-9

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title = "A membrane-permeant, bioactivatable derivative of Ins(1,3,4)P3 and its effect on Cl--secretion from T84 cells",

abstract = "The synthesis of rac-2,5,6-tri-O-butyryl-myo-inositol 1,3,4- trisphosphate hexakis(acetoxymethyl) ester [Bt3-Ins(1,3,4)P3/AM, 1], a membrane-permeant derivative of myo-inositol 1,3,4-trisphosphate [Ins(1,3,4)P3] is reported. 1 inhibited calcium-mediated chloride secretion of T84 cells, suggesting a regulatory link of Ins(1,3,4)P3 and the biosynthesis of the known inhibitor myo-inositol 3,4,5,6-tetrakisphosphate.",

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AU - Rudolf, Marco T.

AU - Traynor-Kaplan, Alexis E.

AU - Schultz, Carsten

PY - 1998/7/21

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AB - The synthesis of rac-2,5,6-tri-O-butyryl-myo-inositol 1,3,4- trisphosphate hexakis(acetoxymethyl) ester [Bt3-Ins(1,3,4)P3/AM, 1], a membrane-permeant derivative of myo-inositol 1,3,4-trisphosphate [Ins(1,3,4)P3] is reported. 1 inhibited calcium-mediated chloride secretion of T84 cells, suggesting a regulatory link of Ins(1,3,4)P3 and the biosynthesis of the known inhibitor myo-inositol 3,4,5,6-tetrakisphosphate.

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A membrane-permeant, bioactivatable derivative of Ins(1,3,4)P₃ and its effect on Cl^--secretion from T₈₄ cells

Abstract

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