A mathematical model for the quantification of mitral regurgitation: Experimental validation in the canine model using contrast echocardiography

John M. Dent, Ananda R. Jayaweera, William P. Glasheen, Stanton P. Nolan, William D. Spotnitz, Flordeliza S. Villanueva, Sanjiv Kaul

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Background. Because the clearance of contrast from the left atrium (LA) relative to the left ventricle (LV) depends on the degree of mitral regurgitation (MR), we hypothesized that a mathematical model can be developed that would provide a quantitative estimation of MR from the washout of contrast from these chambers. Methods and Results. After mathematically developing the model, we performed experiments in two groups of dogs with the use of contrast echocardiography. Group 1 consisted of nine dogs in which different degrees of MR were produced by creating ischemic LV dysfunction. Contrast was injected into the LV, and MR was graded visually on a scale of from 0 to 4+. Videointensity plots generated from the LA and LV were provided to the model. There was excellent correlation between visual assessment of MR and model-derived regurgitant fraction in the 33 stages: y=0.16x+0.002 (r=0.97, p

Original languageEnglish (US)
Pages (from-to)553-562
Number of pages10
JournalCirculation
Volume86
Issue number2
Publication statusPublished - 1992
Externally publishedYes

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Keywords

  • Mitral regurgitation
  • Model, mathematical

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Dent, J. M., Jayaweera, A. R., Glasheen, W. P., Nolan, S. P., Spotnitz, W. D., Villanueva, F. S., & Kaul, S. (1992). A mathematical model for the quantification of mitral regurgitation: Experimental validation in the canine model using contrast echocardiography. Circulation, 86(2), 553-562.