### Abstract

Background. Because the clearance of contrast from the left atrium (LA) relative to the left ventricle (LV) depends on the degree of mitral regurgitation (MR), we hypothesized that a mathematical model can be developed that would provide a quantitative estimation of MR from the washout of contrast from these chambers. Methods and Results. After mathematically developing the model, we performed experiments in two groups of dogs with the use of contrast echocardiography. Group 1 consisted of nine dogs in which different degrees of MR were produced by creating ischemic LV dysfunction. Contrast was injected into the LV, and MR was graded visually on a scale of from 0 to 4+. Videointensity plots generated from the LA and LV were provided to the model. There was excellent correlation between visual assessment of MR and model-derived regurgitant fraction in the 33 stages: y=0.16x+0.002 (r=0.97, p

Original language | English (US) |
---|---|

Pages (from-to) | 553-562 |

Number of pages | 10 |

Journal | Circulation |

Volume | 86 |

Issue number | 2 |

State | Published - 1992 |

Externally published | Yes |

### Fingerprint

### Keywords

- Mitral regurgitation
- Model, mathematical

### ASJC Scopus subject areas

- Physiology
- Cardiology and Cardiovascular Medicine

### Cite this

*Circulation*,

*86*(2), 553-562.

**A mathematical model for the quantification of mitral regurgitation : Experimental validation in the canine model using contrast echocardiography.** / Dent, John M.; Jayaweera, Ananda R.; Glasheen, William P.; Nolan, Stanton P.; Spotnitz, William D.; Villanueva, Flordeliza S.; Kaul, Sanjiv.

Research output: Contribution to journal › Article

*Circulation*, vol. 86, no. 2, pp. 553-562.

}

TY - JOUR

T1 - A mathematical model for the quantification of mitral regurgitation

T2 - Experimental validation in the canine model using contrast echocardiography

AU - Dent, John M.

AU - Jayaweera, Ananda R.

AU - Glasheen, William P.

AU - Nolan, Stanton P.

AU - Spotnitz, William D.

AU - Villanueva, Flordeliza S.

AU - Kaul, Sanjiv

PY - 1992

Y1 - 1992

N2 - Background. Because the clearance of contrast from the left atrium (LA) relative to the left ventricle (LV) depends on the degree of mitral regurgitation (MR), we hypothesized that a mathematical model can be developed that would provide a quantitative estimation of MR from the washout of contrast from these chambers. Methods and Results. After mathematically developing the model, we performed experiments in two groups of dogs with the use of contrast echocardiography. Group 1 consisted of nine dogs in which different degrees of MR were produced by creating ischemic LV dysfunction. Contrast was injected into the LV, and MR was graded visually on a scale of from 0 to 4+. Videointensity plots generated from the LA and LV were provided to the model. There was excellent correlation between visual assessment of MR and model-derived regurgitant fraction in the 33 stages: y=0.16x+0.002 (r=0.97, p

AB - Background. Because the clearance of contrast from the left atrium (LA) relative to the left ventricle (LV) depends on the degree of mitral regurgitation (MR), we hypothesized that a mathematical model can be developed that would provide a quantitative estimation of MR from the washout of contrast from these chambers. Methods and Results. After mathematically developing the model, we performed experiments in two groups of dogs with the use of contrast echocardiography. Group 1 consisted of nine dogs in which different degrees of MR were produced by creating ischemic LV dysfunction. Contrast was injected into the LV, and MR was graded visually on a scale of from 0 to 4+. Videointensity plots generated from the LA and LV were provided to the model. There was excellent correlation between visual assessment of MR and model-derived regurgitant fraction in the 33 stages: y=0.16x+0.002 (r=0.97, p

KW - Mitral regurgitation

KW - Model, mathematical

UR - http://www.scopus.com/inward/record.url?scp=0026736501&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026736501&partnerID=8YFLogxK

M3 - Article

VL - 86

SP - 553

EP - 562

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 2

ER -