A longitudinal study of correlations among tardive dyskinesia, drug- induced parkinsonism, and psychosis

Thomas Hansen, R. M. Weigel, W. L. Brown, W. F. Hoffman, Daniel Casey

Research output: Contribution to journalArticle

3 Scopus citations


Tardive dyskinesia (TD) and drug-induced parkinsonism (DIP) have been hypothesized to reflect opposing states of dopamine (DA) function. In this longitudinal study, 57 psychotic inpatients were rated repeatedly for TD, DIP, and psychosis while receiving neuroleptic medication. Cross-sectional correlations among TD, DIP, and psychosis were weak or nonexistent. Factor and cluster analyses found that 13 patients (23%) were classified into groups characterized by the expected negative correlations. Thus, only partial support was found for the hypothesis that TD and DIP represent opposing states of DA function.

Original languageEnglish (US)
Pages (from-to)29-35
Number of pages7
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number1
Publication statusPublished - 1992
Externally publishedYes


ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

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