A longitudinal study of correlations among tardive dyskinesia, drug- induced parkinsonism, and psychosis

T. E. Hansen; R. M. Weigel; W. L. Brown; W. F. Hoffman; D. E. Casey

doi:10.1176/jnp.4.1.29

A longitudinal study of correlations among tardive dyskinesia, drug- induced parkinsonism, and psychosis

T. E. Hansen, R. M. Weigel, W. L. Brown, W. F. Hoffman, D. E. Casey

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Tardive dyskinesia (TD) and drug-induced parkinsonism (DIP) have been hypothesized to reflect opposing states of dopamine (DA) function. In this longitudinal study, 57 psychotic inpatients were rated repeatedly for TD, DIP, and psychosis while receiving neuroleptic medication. Cross-sectional correlations among TD, DIP, and psychosis were weak or nonexistent. Factor and cluster analyses found that 13 patients (23%) were classified into groups characterized by the expected negative correlations. Thus, only partial support was found for the hypothesis that TD and DIP represent opposing states of DA function.

Original language	English (US)
Pages (from-to)	29-35
Number of pages	7
Journal	Journal of Neuropsychiatry and Clinical Neurosciences
Volume	4
Issue number	1
DOIs	https://doi.org/10.1176/jnp.4.1.29
State	Published - 1992
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

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abstract = "Tardive dyskinesia (TD) and drug-induced parkinsonism (DIP) have been hypothesized to reflect opposing states of dopamine (DA) function. In this longitudinal study, 57 psychotic inpatients were rated repeatedly for TD, DIP, and psychosis while receiving neuroleptic medication. Cross-sectional correlations among TD, DIP, and psychosis were weak or nonexistent. Factor and cluster analyses found that 13 patients (23%) were classified into groups characterized by the expected negative correlations. Thus, only partial support was found for the hypothesis that TD and DIP represent opposing states of DA function.",

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AU - Casey, D. E.

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A longitudinal study of correlations among tardive dyskinesia, drug- induced parkinsonism, and psychosis

Abstract

ASJC Scopus subject areas

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