TY - JOUR
T1 - A longitudinal study evaluating the effects of interferon-alpha therapy on cognitive and psychiatric function in adults with chronic hepatitis C
AU - Huckans, Marilyn
AU - Fuller, Bret
AU - Wheaton, Viva
AU - Jaehnert, Sarah
AU - Ellis, Carilyn
AU - Kolessar, Michael
AU - Kriz, Daniel
AU - Anderson, Jeanne Renee
AU - Berggren, Kristin
AU - Olavarria, Hannah
AU - Sasaki, Anna W.
AU - Chang, Michael
AU - Flora, Kenneth D.
AU - Loftis, Jennifer M.
N1 - Publisher Copyright:
© 2014.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Objective: To prospectively evaluate for changes in objective cognitive performance (attention, memory, and executive function) and psychiatric symptom severity (depression, anxiety, fatigue, and pain) in patients before, during and after interferon-alpha based therapy (IFN) for chronic hepatitis C virus infection (HCV). Methods: 33 HCV. + adults were evaluated two months before IFN initiation (baseline), three months into IFN, and six months following IFN termination (IFN. + Group). 31 HCV. + adults who did not undergo IFN therapy were evaluated at baseline and six months later (IFN. - Group). At each evaluation, participants completed the Neuropsychological Assessment Battery (NAB) Attention, Memory and Executive Functions Modules, the Beck Depression Inventory, Second Edition (BDI), Generalized Anxiety Disorder Inventory (GADI), Fatigue Severity Scale (FSS), and Brief Pain Inventory (BPI). Results: Compared with the IFN. - Group, the IFN. + Group experienced significantly (p. <. 0.050) increased symptoms of depression, anxiety, fatigue and pain during IFN therapy relative to baseline. In the IFN. + Group, psychiatric symptoms generally returned to baseline levels following IFN termination. Sustained viral response was associated with significantly lower depression and fatigue. No significant changes in cognitive performance were observed. Conclusions: During IFN, patients with HCV evidence significantly increased psychiatric symptoms, including symptoms of depression, anxiety, fatigue and pain. These psychiatric symptoms are generally short-term and remit following IFN termination, with increased benefit if viral clearance is achieved. However, IFN is not associated with significant declines in objective cognitive performance during or following IFN.
AB - Objective: To prospectively evaluate for changes in objective cognitive performance (attention, memory, and executive function) and psychiatric symptom severity (depression, anxiety, fatigue, and pain) in patients before, during and after interferon-alpha based therapy (IFN) for chronic hepatitis C virus infection (HCV). Methods: 33 HCV. + adults were evaluated two months before IFN initiation (baseline), three months into IFN, and six months following IFN termination (IFN. + Group). 31 HCV. + adults who did not undergo IFN therapy were evaluated at baseline and six months later (IFN. - Group). At each evaluation, participants completed the Neuropsychological Assessment Battery (NAB) Attention, Memory and Executive Functions Modules, the Beck Depression Inventory, Second Edition (BDI), Generalized Anxiety Disorder Inventory (GADI), Fatigue Severity Scale (FSS), and Brief Pain Inventory (BPI). Results: Compared with the IFN. - Group, the IFN. + Group experienced significantly (p. <. 0.050) increased symptoms of depression, anxiety, fatigue and pain during IFN therapy relative to baseline. In the IFN. + Group, psychiatric symptoms generally returned to baseline levels following IFN termination. Sustained viral response was associated with significantly lower depression and fatigue. No significant changes in cognitive performance were observed. Conclusions: During IFN, patients with HCV evidence significantly increased psychiatric symptoms, including symptoms of depression, anxiety, fatigue and pain. These psychiatric symptoms are generally short-term and remit following IFN termination, with increased benefit if viral clearance is achieved. However, IFN is not associated with significant declines in objective cognitive performance during or following IFN.
KW - Anxiety
KW - Cognition
KW - Depression
KW - Fatigue
KW - Hepatitis c
KW - Interferon
KW - Pain
UR - http://www.scopus.com/inward/record.url?scp=84920878851&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84920878851&partnerID=8YFLogxK
U2 - 10.1016/j.jpsychores.2014.07.020
DO - 10.1016/j.jpsychores.2014.07.020
M3 - Article
C2 - 25219976
AN - SCOPUS:84920878851
SN - 0022-3999
VL - 78
SP - 184
EP - 192
JO - Journal of Psychosomatic Research
JF - Journal of Psychosomatic Research
IS - 2
ER -