A longitudinal study evaluating the effects of interferon-alpha therapy on cognitive and psychiatric function in adults with chronic hepatitis C

Marilyn Huckans, Bret Fuller, Viva Wheaton, Sarah Jaehnert, Carilyn Ellis, Michael Kolessar, Daniel Kriz, Jeanne Renee Anderson, Kristin Berggren, Hannah Olavarria, Anna W. Sasaki, Michael Chang, Kenneth D. Flora, Jennifer Loftis

Research output: Contribution to journalArticle

26 Scopus citations


Objective: To prospectively evaluate for changes in objective cognitive performance (attention, memory, and executive function) and psychiatric symptom severity (depression, anxiety, fatigue, and pain) in patients before, during and after interferon-alpha based therapy (IFN) for chronic hepatitis C virus infection (HCV). Methods: 33 HCV. + adults were evaluated two months before IFN initiation (baseline), three months into IFN, and six months following IFN termination (IFN. + Group). 31 HCV. + adults who did not undergo IFN therapy were evaluated at baseline and six months later (IFN. - Group). At each evaluation, participants completed the Neuropsychological Assessment Battery (NAB) Attention, Memory and Executive Functions Modules, the Beck Depression Inventory, Second Edition (BDI), Generalized Anxiety Disorder Inventory (GADI), Fatigue Severity Scale (FSS), and Brief Pain Inventory (BPI). Results: Compared with the IFN. - Group, the IFN. + Group experienced significantly (p.

Original languageEnglish (US)
Pages (from-to)184-192
Number of pages9
JournalJournal of Psychosomatic Research
Issue number2
Publication statusPublished - Feb 1 2015



  • Anxiety
  • Cognition
  • Depression
  • Fatigue
  • Hepatitis c
  • Interferon
  • Pain

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology
  • Medicine(all)

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