TY - JOUR
T1 - A large-scale North American study of fungal isolates from nails
T2 - The frequency of onychomycosis, fungal distribution, and antifungal susceptibility patterns
AU - Ghannoum, M. A.
AU - Hajjeh, R. A.
AU - Scher, R.
AU - Konnikov, N.
AU - Gupta, A. K.
AU - Summerbell, R.
AU - Sullivan, S.
AU - Daniel, R.
AU - Krusinski, P.
AU - Fleckman, P.
AU - Rich, P.
AU - Odom, R.
AU - Aly, R.
AU - Pariser, D.
AU - Zaiac, M.
AU - Rebell, G.
AU - Lesher, J.
AU - Gerlach, B.
AU - Ponce-de-Leon, G. F.
AU - Ghannoum, A.
AU - Warner, J.
AU - Isham, N.
AU - Elewski, B.
N1 - Funding Information:
Supported by Pfizer Pharmaceutical Group.
PY - 2000
Y1 - 2000
N2 - Background: Onychomycosis, a fungal infection of the nail bed, is responsible for up to 50% of nail disorders. Although several surveys have been conducted in different parts of the world, there have been no multicenter epidemiologic surveys of onychomycosis in North Ameriea. Objective: A 12-center study was undertaken to (1) determine the frequency of onychomycosis, (2) identify organisms recovered from the nails, and (3) determine the antifungal susceptibility of isolates. Methods: A total of 1832 subjects participated in this study and completed a comprehensive questionnaire, and nail clippings were collected for potassium hydroxide examination and culturing. Results: The frequency of onychomycosis, as defined by the presence of septate hyphae on direct microscopy and/or the recovery of a dermatophyte, was found to be 13.8%. In general, the dermatophyte isolates were susceptible to the antifungals tested. Conclusion: Because of the limited number of large-scale studies, the baseline incidence is not firmly established. However, the higher frequency of onychomycosis in this study may confirm the suspected increase in incidence of disease in North America.
AB - Background: Onychomycosis, a fungal infection of the nail bed, is responsible for up to 50% of nail disorders. Although several surveys have been conducted in different parts of the world, there have been no multicenter epidemiologic surveys of onychomycosis in North Ameriea. Objective: A 12-center study was undertaken to (1) determine the frequency of onychomycosis, (2) identify organisms recovered from the nails, and (3) determine the antifungal susceptibility of isolates. Methods: A total of 1832 subjects participated in this study and completed a comprehensive questionnaire, and nail clippings were collected for potassium hydroxide examination and culturing. Results: The frequency of onychomycosis, as defined by the presence of septate hyphae on direct microscopy and/or the recovery of a dermatophyte, was found to be 13.8%. In general, the dermatophyte isolates were susceptible to the antifungals tested. Conclusion: Because of the limited number of large-scale studies, the baseline incidence is not firmly established. However, the higher frequency of onychomycosis in this study may confirm the suspected increase in incidence of disease in North America.
UR - http://www.scopus.com/inward/record.url?scp=0033781077&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033781077&partnerID=8YFLogxK
U2 - 10.1067/mjd.2000.107754
DO - 10.1067/mjd.2000.107754
M3 - Article
C2 - 11004620
AN - SCOPUS:0033781077
SN - 0190-9622
VL - 43
SP - 641
EP - 648
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 4
ER -