A historical perspective of template-based protein structure prediction

Jun Tao Guo, Kyle Ellrott, Ying Xu

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

This chapter presents a broad and a historical overview of the problem, of protein structure prediction. Different structure prediction methods, including homology modeling, fold recognition (FR)/protein threading, ab initio/de novo approaches, and hybrid techniques involving multiple types of approaches, are introduced in a historical context. The progress of the field as a whole, especially in the threading/FR area, as reflected by the CASP/CAFASP contests, is reviewed. At the end of the chapter, we discuss the challenging issues ahead in the field of protein structure prediction.

Original languageEnglish (US)
Pages (from-to)3-42
Number of pages40
JournalMethods in Molecular Biology
Volume413
StatePublished - Oct 5 2007
Externally publishedYes

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Keywords

  • CASP/CAFASP
  • Comparative/homology modeling
  • Energy function
  • Fold recognition
  • Fragment assembly
  • Metaserver
  • Protein threading
  • Structure prediction

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

A historical perspective of template-based protein structure prediction. / Guo, Jun Tao; Ellrott, Kyle; Xu, Ying.

In: Methods in Molecular Biology, Vol. 413, 05.10.2007, p. 3-42.

Research output: Contribution to journalArticle

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