A historical perspective of template-based protein structure prediction

Jun Tao Guo, Kyle Ellrott, Ying Xu

Research output: Chapter in Book/Report/Conference proceedingChapter

17 Scopus citations


This chapter presents a broad and a historical overview of the problem, of protein structure prediction. Different structure prediction methods, including homology modeling, fold recognition (FR)/protein threading, ab initio/de novo approaches, and hybrid techniques involving multiple types of approaches, are introduced in a historical context. The progress of the field as a whole, especially in the threading/FR area, as reflected by the CASP/CAFASP contests, is reviewed. At the end of the chapter, we discuss the challenging issues ahead in the field of protein structure prediction.

Original languageEnglish (US)
Title of host publicationProtein Structure Prediction, Second Edition
EditorsMohammed J. Zaki, Christopher Bystroff
Number of pages40
StatePublished - Oct 5 2007
Externally publishedYes

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Comparative/homology modeling
  • Energy function
  • Fold recognition
  • Fragment assembly
  • Metaserver
  • Protein threading
  • Structure prediction

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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