A highly immunogenic trivalent T cell receptor peptide vaccine for multiple sclerosis

Dennis N. Bourdette, E. Edmonds, C. Smith, J. D. Bowen, C. R.G. Guttmann, Z. P. Nagy, J. Simon, R. Whitham, J. Lovera, V. Yadav, M. Mass, L. Spencer, N. Culbertson, R. M. Bartholomew, G. Theofan, J. Milano, H. Offner, A. A. Vandenbark

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Background: T cell receptor (TCR) peptide vaccination is a novel approach to treating multiple sclerosis (MS). The low immunogenicity of previous vaccines has hindered the development of TCR peptide vaccination for MS. Objective: To compare the immunogenicity of intramuscular injections of TCR BV5S2, BV6S5 and BV13S1 CDR2 peptides in incomplete Freund's adjuvant (IFA) with intradermal injections of the same peptides without IFA. Methods: MS subjects were randomized to receive TCR peptides/IFA, TCR peptides/saline or IFA alone. Subjects were on study for 24 weeks. Results: The TCR peptides/IFA vaccine induced vigorous T cell responses in 100% of subjects completing the 24-week study (9/9) compared with only 20% (2/10) of those receiving the TCR peptides/saline vaccine (P = 0.001). IFA alone induced a weak response in only one of five subjects. Aside from injection site reactions, there were no significant adverse events attributable to the treatment. Conclusions: The trivalent TCR peptide in IFA vaccine represents a significant improvement in immunogenicity over previous TCR peptide vaccines and warrants investigation of its ability to treat MS.

Original languageEnglish (US)
Pages (from-to)552-561
Number of pages10
JournalMultiple Sclerosis
Volume11
Issue number5
DOIs
StatePublished - Oct 1 2005

Keywords

  • Immunoregulation
  • Multiple sclerosis
  • T cell receptor
  • Vaccine

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Bourdette, D. N., Edmonds, E., Smith, C., Bowen, J. D., Guttmann, C. R. G., Nagy, Z. P., Simon, J., Whitham, R., Lovera, J., Yadav, V., Mass, M., Spencer, L., Culbertson, N., Bartholomew, R. M., Theofan, G., Milano, J., Offner, H., & Vandenbark, A. A. (2005). A highly immunogenic trivalent T cell receptor peptide vaccine for multiple sclerosis. Multiple Sclerosis, 11(5), 552-561. https://doi.org/10.1191/1352458505ms1225oa