A hepatic lipase gene promoter polymorphism attenuates the increase in hepatic lipase activity with increasing intra-abdominal fat in women

Molly C. Carr, John E. Hokanson, Samir S. Deeb, Jonathan Q. Purnell, Ellen S. Mitchell, John D. Brunzell

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

High hepatic lipase (HL) activity is associated with an atherogenic lipoprotein profile of small, dense LDL particles and lower HDL2-C. Intra- abdominal fat (IAF) is positively associated with HL activity. A hepatic lipase gene (LIPC) promoter variant (G→A-250) is associated with lower HL activity, higher HDL2-C, and less dense LDL particles. To determine whether the LIPC promoter polymorphism acts independently of IAF to regulate HL, 57 healthy, premenopausal women were studied. The LIPC promoter A allele was associated with significantly lower HL activity (GA/AA= 104±34 versus GG= 145±57 nmoles · mL-1 · min-1, P=0.009). IAF was positively correlated with HL activity (r-0.431, P<0.001). Multivariate analysis revealed a strong relationship between both the LIPC promoter genotype (P=0.001) and IAF (P<0.001) with HL activity. The relationship between IAF and HL activity for carriers and noncarriers of the A allele was curvilinear with the carriers having a lower apparent maximum level of plasma HL activity compared with noncarriers (138 versus 218 nmoles · mL-1 · min-1, P<0.001). In addition, the LIPC A allele was associated with a significantly higher HDL2-C (GA/AA = 16±7 versus GG = 11±5 mg/dL, P=0.003). We conclude that the LIPC promoter A allele attenuates the increase in HL activity due to IAF in premenopausal women.

Original languageEnglish (US)
Pages (from-to)2701-2707
Number of pages7
JournalArteriosclerosis, thrombosis, and vascular biology
Volume19
Issue number11
DOIs
StatePublished - Jan 1 1999

Keywords

  • Cholesterol
  • LIPC
  • Lipoprotein
  • Triglyceride
  • Visceral obesity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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