A hepatic lipase gene promoter polymorphism attenuates the increase in hepatic lipase activity with increasing intra-abdominal fat in women

Molly C. Carr, John E. Hokanson, Samir S. Deeb, Jonathan Purnell, Ellen S. Mitchell, John D. Brunzell

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

High hepatic lipase (HL) activity is associated with an atherogenic lipoprotein profile of small, dense LDL particles and lower HDL 2-C. Intra- abdominal fat (IAF) is positively associated with HL activity. A hepatic lipase gene (LIPC) promoter variant (G→A -250) is associated with lower HL activity, higher HDL 2-C, and less dense LDL particles. To determine whether the LIPC promoter polymorphism acts independently of IAF to regulate HL, 57 healthy, premenopausal women were studied. The LIPC promoter A allele was associated with significantly lower HL activity (GA/AA= 104±34 versus GG= 145±57 nmoles · mL -1 · min -1, P=0.009). IAF was positively correlated with HL activity (r-0.431, P-1 · min -1, P2-C (GA/AA = 16±7 versus GG = 11±5 mg/dL, P=0.003). We conclude that the LIPC promoter A allele attenuates the increase in HL activity due to IAF in premenopausal women.

Original languageEnglish (US)
Pages (from-to)2701-2707
Number of pages7
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume19
Issue number11
StatePublished - 1999
Externally publishedYes

Fingerprint

Intra-Abdominal Fat
Lipase
Liver
Genes
HDL2 Lipoprotein
Alleles
Zanamivir
Lipoproteins

Keywords

  • Cholesterol
  • LIPC
  • Lipoprotein
  • Triglyceride
  • Visceral obesity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

A hepatic lipase gene promoter polymorphism attenuates the increase in hepatic lipase activity with increasing intra-abdominal fat in women. / Carr, Molly C.; Hokanson, John E.; Deeb, Samir S.; Purnell, Jonathan; Mitchell, Ellen S.; Brunzell, John D.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 19, No. 11, 1999, p. 2701-2707.

Research output: Contribution to journalArticle

Carr, Molly C. ; Hokanson, John E. ; Deeb, Samir S. ; Purnell, Jonathan ; Mitchell, Ellen S. ; Brunzell, John D. / A hepatic lipase gene promoter polymorphism attenuates the increase in hepatic lipase activity with increasing intra-abdominal fat in women. In: Arteriosclerosis, Thrombosis, and Vascular Biology. 1999 ; Vol. 19, No. 11. pp. 2701-2707.
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