A global perspective on the influence of environmental exposures on the nervous system

Daniel Tshala-Katumbay, Jean Claude Mwanza, Diane Rohlman, Gladys Maestre, Reinaldo B. Oria

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Economic transitions in the era of globalization warrant a fresh look at the neurological risks associated with environmental change. These are driven by industrial expansion, transfer and mobility of goods, climate change and population growth. In these contexts, risk of infectious and non-infectious diseases are shared across geographical boundaries. In low-and middle-income countries, the risk of environmentally mediated brain disease is augmented several fold by lack of infrastructure, poor health and safety regulations, and limited measures for environmental protection. Neurological disorders may occur as a result of direct exposure to chemical and/or non-chemical stressors, including but not limited to, ultrafine particulate matters. Individual susceptibilities to exposure-related diseases are modified by genetic, epigenetic and metagenomic factors. The existence of several uniquely exposed populations, including those in the areas surrounding the Niger Delta or north western Amazon oil operations; those working in poorly regulated environments, such as artisanal mining industries; or those, mostly in sub-Saharan Africa, relying on cassava as a staple food, offers invaluable opportunities to advance the current understanding of brain responses to environmental challenges. Increased awareness of the brain disorders that are prevalent in low-and middle-income countries and investments in capacity for further environmental health-related research are positive steps towards improving human health.

Original languageEnglish (US)
Pages (from-to)S187-S192
JournalNature
Volume527
Issue number7578
DOIs
StatePublished - Nov 18 2015

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Environmental Exposure
Nervous System
Brain Diseases
Metagenomics
Niger
Manihot
Inborn Genetic Diseases
Internationality
Particulate Matter
Environmental Health
Africa South of the Sahara
Climate Change
Population Growth
Conservation of Natural Resources
Health
Nervous System Diseases
Epigenomics
Industry
Oils
Economics

ASJC Scopus subject areas

  • General

Cite this

A global perspective on the influence of environmental exposures on the nervous system. / Tshala-Katumbay, Daniel; Mwanza, Jean Claude; Rohlman, Diane; Maestre, Gladys; Oria, Reinaldo B.

In: Nature, Vol. 527, No. 7578, 18.11.2015, p. S187-S192.

Research output: Contribution to journalArticle

Tshala-Katumbay, Daniel ; Mwanza, Jean Claude ; Rohlman, Diane ; Maestre, Gladys ; Oria, Reinaldo B. / A global perspective on the influence of environmental exposures on the nervous system. In: Nature. 2015 ; Vol. 527, No. 7578. pp. S187-S192.
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