A giant verruciform xanthoma

Neera Agarwal-Antal, James Zimmermann, Theresa Scholz, R. Dirk Noyes, Sancy Leachman

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7 Scopus citations

Abstract

Background: Verruciform xanthoma (VX) is a rare, benign neoplasm arising predominantly in the oral cavity, but it has been reported to occur on the genital skin and mucosa as well. VX has also been described in association with epidermal nevi and squamous cell carcinoma. Because of the clinical and histologic similarities between VX and condyloma acuminata, and a recent report of HPV 6 in association with VX, we investigated the role of human papilloma virus (HPV) in the development of this entity. Methods: In situ hybridization and a nested PCR approach utilizing degenerate primers were utilized to establish whether HPV infection could be playing a role in the development of the VX. Results: In situ hybridization failed to identify HPV DNA. The highly sensitive nested PCR approach also failed to detect HPV DNA. Conclusions: The failure to detect HPV DNA, even by very sensitive methods, provides strong evidence that our case of VX is not an HPV-induced lesion. A review of other possible etiologies, including alternative infectious agents and genetic associations, are discussed.

Original languageEnglish (US)
Pages (from-to)119-124
Number of pages6
JournalJournal of Cutaneous Pathology
Volume29
Issue number2
DOIs
Publication statusPublished - 2002
Externally publishedYes

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ASJC Scopus subject areas

  • Dermatology
  • Pathology and Forensic Medicine

Cite this

Agarwal-Antal, N., Zimmermann, J., Scholz, T., Dirk Noyes, R., & Leachman, S. (2002). A giant verruciform xanthoma. Journal of Cutaneous Pathology, 29(2), 119-124. https://doi.org/10.1034/j.1600-0560.2002.290210.x