A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome

Carolyn J. Brown, Andrea Ballabio, James L. Rupert, Ronald G. Lafreniere, Markus Grompe, Rossana Tonlorenzi, Huntington F. Willard

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Abstract

X-chromosome inactivation results in the cis-limited dosage compensation of genes on one of the pair of X chromosomes in mammalian females. Although most X-linked genes are believed to be subject to inactivation, several are known to be expressed from both active and inactive X chromosomes. Here we describe an X-linked gene with a novel expression pattern - transcripts are detected only from the inactive X chromosome (Xi) and not from the active X chromosome (Xa). This gene, called XIST (for Xi-specific transcripts), is a candidate for a gene either involved in or uniquely influenced by the process of X inactivation.

Original languageEnglish (US)
Pages (from-to)38-44
Number of pages7
JournalNature
Volume349
Issue number6304
DOIs
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • General

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    Brown, C. J., Ballabio, A., Rupert, J. L., Lafreniere, R. G., Grompe, M., Tonlorenzi, R., & Willard, H. F. (1991). A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome. Nature, 349(6304), 38-44. https://doi.org/10.1038/349038a0