A G protein-coupled receptor is essential for schwann cells to initiate myelination

Kelly Monk, Stephen G. Naylor, Thomas D. Glenn, Sara Mercurio, Julie R. Perlin, Claudia Dominguez, Cecilia B. Moens, William S. Talbot

Research output: Contribution to journalArticle

192 Citations (Scopus)

Abstract

The myelin sheath allows axons to conduct action potentials rapidly in the vertebrate nervous system. Axonal signals activate expression of specific transcription factors, including Oct6 and Krox20, that initiate myelination in Schwann cells. Elevation of cyclic adenosine monophosphate (cAMP) can mimic axonal contact in vitro, but the mechanisms that regulate cAMP levels in vivo are unknown. Using mutational analysis in zebrafish, we found that the G protein-coupled receptor Gpr126 is required autonomously in Schwann cells for myelination. In gpr126 mutants, Schwann cells failed to express oct6 and krox20 and were arrested at the promyelinating stage. Elevation of cAMP in gpr126 mutants, but not krox20 mutants, could restore myelination. We propose that Gpr126 drives the differentiation of promyelinating Schwann cells by elevating cAMP levels, thereby triggering Oct6 expression and myelination.

Original languageEnglish (US)
Pages (from-to)1402-1405
Number of pages4
JournalScience
Volume325
Issue number5946
DOIs
StatePublished - Sep 18 2009
Externally publishedYes

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Schwann Cells
G-Protein-Coupled Receptors
Cyclic AMP
Zebrafish
Myelin Sheath
Nervous System
Action Potentials
Axons
Vertebrates
Transcription Factors

ASJC Scopus subject areas

  • Medicine(all)
  • General

Cite this

Monk, K., Naylor, S. G., Glenn, T. D., Mercurio, S., Perlin, J. R., Dominguez, C., ... Talbot, W. S. (2009). A G protein-coupled receptor is essential for schwann cells to initiate myelination. Science, 325(5946), 1402-1405. https://doi.org/10.1126/science.1173474

A G protein-coupled receptor is essential for schwann cells to initiate myelination. / Monk, Kelly; Naylor, Stephen G.; Glenn, Thomas D.; Mercurio, Sara; Perlin, Julie R.; Dominguez, Claudia; Moens, Cecilia B.; Talbot, William S.

In: Science, Vol. 325, No. 5946, 18.09.2009, p. 1402-1405.

Research output: Contribution to journalArticle

Monk, K, Naylor, SG, Glenn, TD, Mercurio, S, Perlin, JR, Dominguez, C, Moens, CB & Talbot, WS 2009, 'A G protein-coupled receptor is essential for schwann cells to initiate myelination', Science, vol. 325, no. 5946, pp. 1402-1405. https://doi.org/10.1126/science.1173474
Monk K, Naylor SG, Glenn TD, Mercurio S, Perlin JR, Dominguez C et al. A G protein-coupled receptor is essential for schwann cells to initiate myelination. Science. 2009 Sep 18;325(5946):1402-1405. https://doi.org/10.1126/science.1173474
Monk, Kelly ; Naylor, Stephen G. ; Glenn, Thomas D. ; Mercurio, Sara ; Perlin, Julie R. ; Dominguez, Claudia ; Moens, Cecilia B. ; Talbot, William S. / A G protein-coupled receptor is essential for schwann cells to initiate myelination. In: Science. 2009 ; Vol. 325, No. 5946. pp. 1402-1405.
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