Abstract
The PvuΔ mutant of Friend spleen focus-forming virus encodes the smallest env glycoprotein (apparent M(r), 41,000) known to activate erythropoietin receptors. In vivo, PvuΔ causes erythroblastosis and the development of erythroleukemia. We isolated two leukemic cell lines that contain PvuΔ; both synthesize hemoglobin in response to dimethyl sulfoxide. The PvuΔ env gene contains a 204-base deletion in the ecotropic-specific region, suggesting that this domain of the glycoprotein is not essential for viral pathogenesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4053-4056 |
| Number of pages | 4 |
| Journal | Journal of Virology |
| Volume | 68 |
| Issue number | 6 |
| State | Published - Jun 1994 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
Cite this
A Friend virus mutant encodes a small glycoprotein that causes erythroleukemia. / Hoatlin, Maureen; Ferro, Frank E.; Kozak, Susan L.; Kabat, David.
In: Journal of Virology, Vol. 68, No. 6, 06.1994, p. 4053-4056.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A Friend virus mutant encodes a small glycoprotein that causes erythroleukemia
AU - Hoatlin, Maureen
AU - Ferro, Frank E.
AU - Kozak, Susan L.
AU - Kabat, David
PY - 1994/6
Y1 - 1994/6
N2 - The PvuΔ mutant of Friend spleen focus-forming virus encodes the smallest env glycoprotein (apparent M(r), 41,000) known to activate erythropoietin receptors. In vivo, PvuΔ causes erythroblastosis and the development of erythroleukemia. We isolated two leukemic cell lines that contain PvuΔ; both synthesize hemoglobin in response to dimethyl sulfoxide. The PvuΔ env gene contains a 204-base deletion in the ecotropic-specific region, suggesting that this domain of the glycoprotein is not essential for viral pathogenesis.
AB - The PvuΔ mutant of Friend spleen focus-forming virus encodes the smallest env glycoprotein (apparent M(r), 41,000) known to activate erythropoietin receptors. In vivo, PvuΔ causes erythroblastosis and the development of erythroleukemia. We isolated two leukemic cell lines that contain PvuΔ; both synthesize hemoglobin in response to dimethyl sulfoxide. The PvuΔ env gene contains a 204-base deletion in the ecotropic-specific region, suggesting that this domain of the glycoprotein is not essential for viral pathogenesis.
UR - http://www.scopus.com/inward/record.url?scp=0028321659&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028321659&partnerID=8YFLogxK
M3 - Article
C2 - 8189542
AN - SCOPUS:0028321659
VL - 68
SP - 4053
EP - 4056
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 6
ER -