Abstract
The PvuΔ mutant of Friend spleen focus-forming virus encodes the smallest env glycoprotein (apparent M(r), 41,000) known to activate erythropoietin receptors. In vivo, PvuΔ causes erythroblastosis and the development of erythroleukemia. We isolated two leukemic cell lines that contain PvuΔ; both synthesize hemoglobin in response to dimethyl sulfoxide. The PvuΔ env gene contains a 204-base deletion in the ecotropic-specific region, suggesting that this domain of the glycoprotein is not essential for viral pathogenesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4053-4056 |
| Number of pages | 4 |
| Journal | Journal of virology |
| Volume | 68 |
| Issue number | 6 |
| State | Published - Jun 1 1994 |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology
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Cite this
Hoatlin, M. E., Ferro, F. E., Kozak, S. L., & Kabat, D. (1994). A Friend virus mutant encodes a small glycoprotein that causes erythroleukemia. Journal of virology, 68(6), 4053-4056.