A Friend virus mutant encodes a small glycoprotein that causes erythroleukemia

Maureen E. Hoatlin; Frank E. Ferro; Susan L. Kozak; David Kabat

doi:10.1128/jvi.68.6.4053-4056.1994

A Friend virus mutant encodes a small glycoprotein that causes erythroleukemia

Maureen E. Hoatlin, Frank E. Ferro, Susan L. Kozak, David Kabat

Biochemistry & Molecular Biology

Research output: Contribution to journal › Comment/debate › peer-review

6 Scopus citations

Abstract

The PvuΔ mutant of Friend spleen focus-forming virus encodes the smallest env glycoprotein (apparent M(r), 41,000) known to activate erythropoietin receptors. In vivo, PvuΔ causes erythroblastosis and the development of erythroleukemia. We isolated two leukemic cell lines that contain PvuΔ; both synthesize hemoglobin in response to dimethyl sulfoxide. The PvuΔ env gene contains a 204-base deletion in the ecotropic-specific region, suggesting that this domain of the glycoprotein is not essential for viral pathogenesis.

Original language	English (US)
Pages (from-to)	4053-4056
Number of pages	4
Journal	Journal of virology
Volume	68
Issue number	6
DOIs	https://doi.org/10.1128/jvi.68.6.4053-4056.1994
State	Published - Jun 1994

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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abstract = "The PvuΔ mutant of Friend spleen focus-forming virus encodes the smallest env glycoprotein (apparent M(r), 41,000) known to activate erythropoietin receptors. In vivo, PvuΔ causes erythroblastosis and the development of erythroleukemia. We isolated two leukemic cell lines that contain PvuΔ; both synthesize hemoglobin in response to dimethyl sulfoxide. The PvuΔ env gene contains a 204-base deletion in the ecotropic-specific region, suggesting that this domain of the glycoprotein is not essential for viral pathogenesis.",

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AU - Ferro, Frank E.

AU - Kozak, Susan L.

AU - Kabat, David

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N2 - The PvuΔ mutant of Friend spleen focus-forming virus encodes the smallest env glycoprotein (apparent M(r), 41,000) known to activate erythropoietin receptors. In vivo, PvuΔ causes erythroblastosis and the development of erythroleukemia. We isolated two leukemic cell lines that contain PvuΔ; both synthesize hemoglobin in response to dimethyl sulfoxide. The PvuΔ env gene contains a 204-base deletion in the ecotropic-specific region, suggesting that this domain of the glycoprotein is not essential for viral pathogenesis.

AB - The PvuΔ mutant of Friend spleen focus-forming virus encodes the smallest env glycoprotein (apparent M(r), 41,000) known to activate erythropoietin receptors. In vivo, PvuΔ causes erythroblastosis and the development of erythroleukemia. We isolated two leukemic cell lines that contain PvuΔ; both synthesize hemoglobin in response to dimethyl sulfoxide. The PvuΔ env gene contains a 204-base deletion in the ecotropic-specific region, suggesting that this domain of the glycoprotein is not essential for viral pathogenesis.

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JO - Journal of Virology

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A Friend virus mutant encodes a small glycoprotein that causes erythroleukemia

Abstract

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