A Friend virus mutant encodes a small glycoprotein that causes erythroleukemia

Maureen Hoatlin, Frank E. Ferro, Susan L. Kozak, David Kabat

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The PvuΔ mutant of Friend spleen focus-forming virus encodes the smallest env glycoprotein (apparent M(r), 41,000) known to activate erythropoietin receptors. In vivo, PvuΔ causes erythroblastosis and the development of erythroleukemia. We isolated two leukemic cell lines that contain PvuΔ; both synthesize hemoglobin in response to dimethyl sulfoxide. The PvuΔ env gene contains a 204-base deletion in the ecotropic-specific region, suggesting that this domain of the glycoprotein is not essential for viral pathogenesis.

Original languageEnglish (US)
Pages (from-to)4053-4056
Number of pages4
JournalJournal of Virology
Volume68
Issue number6
StatePublished - Jun 1994
Externally publishedYes

Fingerprint

Spleen Focus-Forming Viruses
Friend murine leukemia virus
env Gene Products
Erythropoietin Receptors
env Genes
Leukemia, Erythroblastic, Acute
Dimethyl Sulfoxide
glycoproteins
Glycoproteins
Hemoglobins
Cell Line
erythropoietin
viruses
mutants
dimethyl sulfoxide
hemoglobin
spleen
pathogenesis
cell lines
receptors

ASJC Scopus subject areas

  • Immunology

Cite this

Hoatlin, M., Ferro, F. E., Kozak, S. L., & Kabat, D. (1994). A Friend virus mutant encodes a small glycoprotein that causes erythroleukemia. Journal of Virology, 68(6), 4053-4056.

A Friend virus mutant encodes a small glycoprotein that causes erythroleukemia. / Hoatlin, Maureen; Ferro, Frank E.; Kozak, Susan L.; Kabat, David.

In: Journal of Virology, Vol. 68, No. 6, 06.1994, p. 4053-4056.

Research output: Contribution to journalArticle

Hoatlin, M, Ferro, FE, Kozak, SL & Kabat, D 1994, 'A Friend virus mutant encodes a small glycoprotein that causes erythroleukemia', Journal of Virology, vol. 68, no. 6, pp. 4053-4056.
Hoatlin, Maureen ; Ferro, Frank E. ; Kozak, Susan L. ; Kabat, David. / A Friend virus mutant encodes a small glycoprotein that causes erythroleukemia. In: Journal of Virology. 1994 ; Vol. 68, No. 6. pp. 4053-4056.
@article{661e32ac6cd945fbadfb791e5ae6fba9,
title = "A Friend virus mutant encodes a small glycoprotein that causes erythroleukemia",
abstract = "The PvuΔ mutant of Friend spleen focus-forming virus encodes the smallest env glycoprotein (apparent M(r), 41,000) known to activate erythropoietin receptors. In vivo, PvuΔ causes erythroblastosis and the development of erythroleukemia. We isolated two leukemic cell lines that contain PvuΔ; both synthesize hemoglobin in response to dimethyl sulfoxide. The PvuΔ env gene contains a 204-base deletion in the ecotropic-specific region, suggesting that this domain of the glycoprotein is not essential for viral pathogenesis.",
author = "Maureen Hoatlin and Ferro, {Frank E.} and Kozak, {Susan L.} and David Kabat",
year = "1994",
month = "6",
language = "English (US)",
volume = "68",
pages = "4053--4056",
journal = "Journal of Virology",
issn = "0022-538X",
publisher = "American Society for Microbiology",
number = "6",

}

TY - JOUR

T1 - A Friend virus mutant encodes a small glycoprotein that causes erythroleukemia

AU - Hoatlin, Maureen

AU - Ferro, Frank E.

AU - Kozak, Susan L.

AU - Kabat, David

PY - 1994/6

Y1 - 1994/6

N2 - The PvuΔ mutant of Friend spleen focus-forming virus encodes the smallest env glycoprotein (apparent M(r), 41,000) known to activate erythropoietin receptors. In vivo, PvuΔ causes erythroblastosis and the development of erythroleukemia. We isolated two leukemic cell lines that contain PvuΔ; both synthesize hemoglobin in response to dimethyl sulfoxide. The PvuΔ env gene contains a 204-base deletion in the ecotropic-specific region, suggesting that this domain of the glycoprotein is not essential for viral pathogenesis.

AB - The PvuΔ mutant of Friend spleen focus-forming virus encodes the smallest env glycoprotein (apparent M(r), 41,000) known to activate erythropoietin receptors. In vivo, PvuΔ causes erythroblastosis and the development of erythroleukemia. We isolated two leukemic cell lines that contain PvuΔ; both synthesize hemoglobin in response to dimethyl sulfoxide. The PvuΔ env gene contains a 204-base deletion in the ecotropic-specific region, suggesting that this domain of the glycoprotein is not essential for viral pathogenesis.

UR - http://www.scopus.com/inward/record.url?scp=0028321659&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028321659&partnerID=8YFLogxK

M3 - Article

C2 - 8189542

AN - SCOPUS:0028321659

VL - 68

SP - 4053

EP - 4056

JO - Journal of Virology

JF - Journal of Virology

SN - 0022-538X

IS - 6

ER -