A Friend virus mutant encodes a small glycoprotein that causes erythroleukemia

Maureen E. Hoatlin, Frank E. Ferro, Susan L. Kozak, David Kabat

Research output: Contribution to journalComment/debate

6 Scopus citations

Abstract

The PvuΔ mutant of Friend spleen focus-forming virus encodes the smallest env glycoprotein (apparent M(r), 41,000) known to activate erythropoietin receptors. In vivo, PvuΔ causes erythroblastosis and the development of erythroleukemia. We isolated two leukemic cell lines that contain PvuΔ; both synthesize hemoglobin in response to dimethyl sulfoxide. The PvuΔ env gene contains a 204-base deletion in the ecotropic-specific region, suggesting that this domain of the glycoprotein is not essential for viral pathogenesis.

Original languageEnglish (US)
Pages (from-to)4053-4056
Number of pages4
JournalJournal of virology
Volume68
Issue number6
StatePublished - Jun 1 1994

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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