A feasibility study of optical coherence tomography for guiding deep brain probes

Sung W. Jeon, Mark A. Shure, Ken B. Baker, David Huang, Andrew M. Rollins, Ali Chahlavi, Ali R. Rezai

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

Deep brain simulation (DBS) is effective for the treatment of various diseases including Parkinson's disease and essential tremor. However, anatomical targeting combined with microelectrode mapping of the region requires significant surgical time. Also, the fine-tipped microelectrode imposes a risk of hemorrhage in the event that the trajectory intersects subcortical vessels. To reduce the operation time and the risk of hemorrhage, we propose to use optical coherence tomography (OCT) to guide the insertion of the DBS probe. We conducted in vitro experiments in the rat brain to study the feasibility of this application. The result shows that OCT is able to differentiate structures in the rat brain. White matter tends to have higher peak reflectivity and steeper attenuation rate compared to gray matter. This structural information may help guide DBS probe advance and electrical measurements.

Original languageEnglish (US)
Pages (from-to)96-101
Number of pages6
JournalJournal of Neuroscience Methods
Volume154
Issue number1-2
DOIs
StatePublished - Jun 30 2006

Keywords

  • Deep brain stimulation
  • Optical coherence domain reflectometry
  • Optical coherence tomography
  • Rat brain
  • Tissue classification

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Jeon, S. W., Shure, M. A., Baker, K. B., Huang, D., Rollins, A. M., Chahlavi, A., & Rezai, A. R. (2006). A feasibility study of optical coherence tomography for guiding deep brain probes. Journal of Neuroscience Methods, 154(1-2), 96-101. https://doi.org/10.1016/j.jneumeth.2005.12.008