A family of acid-sensing ion channels from the zebrafish: Widespread expression in the central nervous system suggests a conserved role in neuronal communication

Martin Paukert, Samuel Sidi, Claire Russell, Maria Siba, Stephen W. Wilson, Teresa Nicolson, Stefan Gründer

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Acid-sensing ion channels (ASICs) are excitatory receptors for extracellular H+. Proposed functions include synaptic transmission, peripheral perception of pain, and mechanosensation. Despite the physiological importance of these functions, the precise role of ASICs has not yet been established. In order to increase our understanding of the physiological role and basic structure-function relationships of ASICs, we report here the cloning of six new ASICs from the zebrafish (zASICs). zASICs possess the basic functional properties of mammalian ASICs: activation by extracellular H +, Na+ selectivity, and block by micromolar concentrations of amiloride. The zasic genes are broadly expressed in the central nervous system, whereas expression in the peripheral nervous system is scarce. This pattern suggests a predominant role for zASICs in neuronal communication. Our results suggest a conserved function for receptors of extracellular H+ in the central nervous system of vertebrates.

Original languageEnglish (US)
Pages (from-to)18783-18791
Number of pages9
JournalJournal of Biological Chemistry
Volume279
Issue number18
DOIs
StatePublished - Apr 30 2004

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Acid Sensing Ion Channels
Neurology
Zebrafish
Central Nervous System
Communication
Pain Perception
Amiloride
Cloning
Peripheral Nervous System
Synaptic Transmission
Vertebrates
Organism Cloning
Genes
Chemical activation

ASJC Scopus subject areas

  • Biochemistry

Cite this

A family of acid-sensing ion channels from the zebrafish : Widespread expression in the central nervous system suggests a conserved role in neuronal communication. / Paukert, Martin; Sidi, Samuel; Russell, Claire; Siba, Maria; Wilson, Stephen W.; Nicolson, Teresa; Gründer, Stefan.

In: Journal of Biological Chemistry, Vol. 279, No. 18, 30.04.2004, p. 18783-18791.

Research output: Contribution to journalArticle

Paukert, Martin ; Sidi, Samuel ; Russell, Claire ; Siba, Maria ; Wilson, Stephen W. ; Nicolson, Teresa ; Gründer, Stefan. / A family of acid-sensing ion channels from the zebrafish : Widespread expression in the central nervous system suggests a conserved role in neuronal communication. In: Journal of Biological Chemistry. 2004 ; Vol. 279, No. 18. pp. 18783-18791.
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