A double-blinded comparative study of sultamicillin and potassium penicillin v in the treatment of childhood streptococcal pharyngitis

Stephen C. Aronoff, Jeffrey D. Klinger, Cheryl A. O'brien, Arthur Jaffe, Jeffrey L. Blumer

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Fifty-two children with positive pharyngeal cultures for group A streptococci were randomized to receive phenoxymethyl penicillin or sultamicillin, an ester of ampicillin and sulbactam. By serological and bacteriological criteria, sultamicillin was effective in 100% of the 20 evaluable cases of infection and carriage while penicillin was effective in six out of eight (75%) and three out of eight (93%) respectively. Of the eight children with infections treated with sultamicillin, three (37.5%) became recolonized with the organism compared to none of the children in the penicillin group. These differences were not statistically significant.

Original languageEnglish (US)
Pages (from-to)261-265
Number of pages5
JournalJournal of Antimicrobial Chemotherapy
Volume14
Issue number3
DOIs
StatePublished - Sep 1984
Externally publishedYes

Fingerprint

Pharyngitis
Potassium
Penicillins
Comparative Study
Esters
Infection
Penicillin V
Therapeutics
Streptococcus
sultamicillin
Children
Childhood
Comparative study

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)
  • Pharmacology
  • Microbiology

Cite this

A double-blinded comparative study of sultamicillin and potassium penicillin v in the treatment of childhood streptococcal pharyngitis. / Aronoff, Stephen C.; Klinger, Jeffrey D.; O'brien, Cheryl A.; Jaffe, Arthur; Blumer, Jeffrey L.

In: Journal of Antimicrobial Chemotherapy, Vol. 14, No. 3, 09.1984, p. 261-265.

Research output: Contribution to journalArticle

Aronoff, Stephen C. ; Klinger, Jeffrey D. ; O'brien, Cheryl A. ; Jaffe, Arthur ; Blumer, Jeffrey L. / A double-blinded comparative study of sultamicillin and potassium penicillin v in the treatment of childhood streptococcal pharyngitis. In: Journal of Antimicrobial Chemotherapy. 1984 ; Vol. 14, No. 3. pp. 261-265.
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