A double-blinded comparative study of sultamicillin and potassium penicillin v in the treatment of childhood streptococcal pharyngitis

Stephen C. Aronoff, Jeffrey D. Klinger, Cheryl A. O'brien, Arthur C. Jaffe, Jeffrey L. Blumer

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Fifty-two children with positive pharyngeal cultures for group A streptococci were randomized to receive phenoxymethyl penicillin or sultamicillin, an ester of ampicillin and sulbactam. By serological and bacteriological criteria, sultamicillin was effective in 100% of the 20 evaluable cases of infection and carriage while penicillin was effective in six out of eight (75%) and three out of eight (93%) respectively. Of the eight children with infections treated with sultamicillin, three (37.5%) became recolonized with the organism compared to none of the children in the penicillin group. These differences were not statistically significant.

Original languageEnglish (US)
Pages (from-to)261-265
Number of pages5
JournalJournal of Antimicrobial Chemotherapy
Volume14
Issue number3
DOIs
StatePublished - Sep 1 1984

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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