TY - JOUR
T1 - A developmental switch in lymphocyte homing receptor and endothelial vascular addressin expression regulates lymphocyte homing and permits CD4+CD3- cells to colonize lymph nodes
AU - Mebius, Reina E.
AU - Streeter, Philip R.
AU - Michie, Sara
AU - Butcher, Eugene C.
AU - Weissman, Irving L.
PY - 1996/10/1
Y1 - 1996/10/1
N2 - In adult mice, the dominant adhesion molecules involved in homing to lymph nodes are L-selectin homing receptors on lymphocytes and the peripheral lymph node addressins on specialized high endothelial venules. Here we show that, from fetal life through the first 24 hr of life, the dominant adhesion molecules are the mucosal addressin MAdCAM-1 on lymph node high endothelial venules and its counterreceptor, the Peyer's patch homing receptor, integrin α4β7 on circulating cells. Before birth, 40-70% of peripheral blood leukocytes are L-selectin-positive, while only 1-2% expresses α4β7. However, the fetal lymph nodes preferentially attract α4β7-expressing cells, and this can be blocked by fetal administration of anti-MAdCAM-1 antibodies. During fetal and early neonatal life, when only MAdCAM-1 is expressed on high endothelial venules, an unusual subset of CD4+CD3- cells, exclusively expressing α4β7 as homing receptors, enters the lymph nodes. Beginning 24 hr after birth a developmental switch occurs, and the peripheral node addressins are upregulated on high endothelial venules in peripheral and mesenteric lymph nodes. This switch in addressin expression facilitates tissue-selective lymphocyte migration and mediates a sequential entry of different cell populations into the lymph nodes.
AB - In adult mice, the dominant adhesion molecules involved in homing to lymph nodes are L-selectin homing receptors on lymphocytes and the peripheral lymph node addressins on specialized high endothelial venules. Here we show that, from fetal life through the first 24 hr of life, the dominant adhesion molecules are the mucosal addressin MAdCAM-1 on lymph node high endothelial venules and its counterreceptor, the Peyer's patch homing receptor, integrin α4β7 on circulating cells. Before birth, 40-70% of peripheral blood leukocytes are L-selectin-positive, while only 1-2% expresses α4β7. However, the fetal lymph nodes preferentially attract α4β7-expressing cells, and this can be blocked by fetal administration of anti-MAdCAM-1 antibodies. During fetal and early neonatal life, when only MAdCAM-1 is expressed on high endothelial venules, an unusual subset of CD4+CD3- cells, exclusively expressing α4β7 as homing receptors, enters the lymph nodes. Beginning 24 hr after birth a developmental switch occurs, and the peripheral node addressins are upregulated on high endothelial venules in peripheral and mesenteric lymph nodes. This switch in addressin expression facilitates tissue-selective lymphocyte migration and mediates a sequential entry of different cell populations into the lymph nodes.
KW - MAdCAM-1
KW - lymphocyte migration
KW - ontogeny
UR - http://www.scopus.com/inward/record.url?scp=0029744338&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029744338&partnerID=8YFLogxK
U2 - 10.1073/pnas.93.20.11019
DO - 10.1073/pnas.93.20.11019
M3 - Article
C2 - 8855301
AN - SCOPUS:0029744338
SN - 0027-8424
VL - 93
SP - 11019
EP - 11024
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 20
ER -