A designed antagonist of the thyroid hormone receptor

Hikari A.I. Yoshihara, James W. Apriletti, John D. Baxter, Thomas S. Scanlan

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

We synthesized an analogue of the thyromimetic GC-1 bearing the same hydrophobic appendage as the estrogen receptor antagonist ICI-164,384. While having reduced affinity for the thyroid hormone receptors compared to GC-1, it behaves in a manner consistent with a competitive antagonist in a transactivation assay.

Original languageEnglish (US)
Pages (from-to)2821-2825
Number of pages5
JournalBioorganic & medicinal chemistry letters
Volume11
Issue number21
DOIs
StatePublished - Nov 5 2001

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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