@article{cac2afd7f1a846539f1329c4f012301f,
title = "A designed antagonist of the thyroid hormone receptor",
abstract = "We synthesized an analogue of the thyromimetic GC-1 bearing the same hydrophobic appendage as the estrogen receptor antagonist ICI-164,384. While having reduced affinity for the thyroid hormone receptors compared to GC-1, it behaves in a manner consistent with a competitive antagonist in a transactivation assay.",
author = "Yoshihara, {Hikari A.I.} and Apriletti, {James W.} and Baxter, {John D.} and Scanlan, {Thomas S.}",
note = "Funding Information: This work was supported by the National Institutes of Health (DK52798, T.S.S.). H.A.I.Y. is grateful for financial support from the National Cancer Institute, Institutional Training Grant T32 CA09270, with supplemental support from the UCSF Dept. of Biochemistry's Herbert W. Boyer Fund. We thank Martin Privalsky and Keith Yamamoto for the gifts of plasmids, used in the transfection assay. J.D.B. has proprietary interests in, and serves as a consultant and Deputy director to, Karo Bio AB that has commercial interests in this area of research. ",
year = "2001",
month = nov,
day = "5",
doi = "10.1016/S0960-894X(01)00521-2",
language = "English (US)",
volume = "11",
pages = "2821--2825",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "21",
}