Abstract
We synthesized an analogue of the thyromimetic GC-1 bearing the same hydrophobic appendage as the estrogen receptor antagonist ICI-164,384. While having reduced affinity for the thyroid hormone receptors compared to GC-1, it behaves in a manner consistent with a competitive antagonist in a transactivation assay.
Original language | English (US) |
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Pages (from-to) | 2821-2825 |
Number of pages | 5 |
Journal | Bioorganic & medicinal chemistry letters |
Volume | 11 |
Issue number | 21 |
DOIs | |
State | Published - Nov 5 2001 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry