A cytomegalovirus-based vaccine provides long-lasting protection against lethal Ebola virus challenge after a single dose

Yoshimi Tsuda; Christopher J. Parkins; Patrizia Caposio; Friederike Feldmann; Sara Botto; Susan Ball; Ilhem Messaoudi; Luka Cicin-Sain; Heinz Feldmann; Michael A. Jarvis

doi:10.1016/j.vaccine.2015.03.029

A cytomegalovirus-based vaccine provides long-lasting protection against lethal Ebola virus challenge after a single dose

Yoshimi Tsuda, Christopher J. Parkins, Patrizia Caposio, Friederike Feldmann, Sara Botto, Susan Ball, Ilhem Messaoudi, Luka Cicin-Sain, Heinz Feldmann, Michael A. Jarvis

Vaccine and Gene Therapy Institute

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Ebola virus (Zaire ebolavirus; EBOV) is a highly lethal hemorrhagic disease virus that most recently was responsible for two independent 2014 outbreaks in multiple countries in Western Africa, and the Democratic Republic of the Congo, respectively. Herein, we show that a cytomegalovirus (CMV)-based vaccine provides durable protective immunity from Ebola virus following a single vaccine dose. This study has implications for human vaccination against ebolaviruses, as well as for development of a 'disseminating' vaccine to target these viruses in wild African great apes.

Original language	English (US)
Pages (from-to)	2261-2266
Number of pages	6
Journal	Vaccine
Volume	33
Issue number	19
DOIs	https://doi.org/10.1016/j.vaccine.2015.03.029
State	Published - 2015

Keywords

Cytomegalovirus
Disseminating
Durable
Ebola
Ebolavirus
Great apes
Mouse
Protection
Vaccine

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/j.vaccine.2015.03.029

Cite this

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abstract = "Ebola virus (Zaire ebolavirus; EBOV) is a highly lethal hemorrhagic disease virus that most recently was responsible for two independent 2014 outbreaks in multiple countries in Western Africa, and the Democratic Republic of the Congo, respectively. Herein, we show that a cytomegalovirus (CMV)-based vaccine provides durable protective immunity from Ebola virus following a single vaccine dose. This study has implications for human vaccination against ebolaviruses, as well as for development of a 'disseminating' vaccine to target these viruses in wild African great apes.",

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AU - Tsuda, Yoshimi

AU - Parkins, Christopher J.

AU - Caposio, Patrizia

AU - Feldmann, Friederike

AU - Botto, Sara

AU - Ball, Susan

AU - Messaoudi, Ilhem

AU - Cicin-Sain, Luka

AU - Feldmann, Heinz

AU - Jarvis, Michael A.

PY - 2015

Y1 - 2015

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AB - Ebola virus (Zaire ebolavirus; EBOV) is a highly lethal hemorrhagic disease virus that most recently was responsible for two independent 2014 outbreaks in multiple countries in Western Africa, and the Democratic Republic of the Congo, respectively. Herein, we show that a cytomegalovirus (CMV)-based vaccine provides durable protective immunity from Ebola virus following a single vaccine dose. This study has implications for human vaccination against ebolaviruses, as well as for development of a 'disseminating' vaccine to target these viruses in wild African great apes.

KW - Cytomegalovirus

KW - Disseminating

KW - Durable

KW - Ebola

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KW - Great apes

KW - Mouse

KW - Protection

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A cytomegalovirus-based vaccine provides long-lasting protection against lethal Ebola virus challenge after a single dose

Abstract

Keywords

ASJC Scopus subject areas

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