A curated census of autophagy-modulating proteins and small molecules: Candidate targets for cancer therapy

Philip L. Lorenzi, Sofie Claerhout, Gordon B. Mills, John N. Weinstein

    Research output: Contribution to journalArticle

    26 Scopus citations

    Abstract

    Autophagy, a programmed process in which cell contents are delivered to lysosomes for degradation, appears to have both tumor-suppressive and tumor-promoting functions; both stimulation and inhibition of autophagy have been reported to induce cancer cell death, and particular genes and proteins have been associated both positively and negatively with autophagy. To provide a basis for incisive analysis of those complexities and ambiguities and to guide development of new autophagy-targeted treatments for cancer, we have compiled a comprehensive, curated inventory of autophagy modulators by integrating information from published siRNA screens, multiple pathway analysis algorithms, and extensive, manually curated text-mining of the literature. The resulting inventory includes 739 proteins and 385 chemicals (including drugs, small molecules, and metabolites). Because autophagy is still at an early stage of investigation, we provide extensive analysis of our sources of information and their complex relationships with each other. We conclude with a discussion of novel strategies that could potentially be used to target autophagy for cancer therapy.

    Original languageEnglish (US)
    Pages (from-to)1316-1326
    Number of pages11
    JournalAutophagy
    Volume10
    Issue number7
    DOIs
    StatePublished - Jul 2014

    Keywords

    • Autophagy
    • Cancer
    • High-throughput screening
    • L-asparaginase
    • Natural language processing
    • Pathway analysis
    • RNAi
    • Text-mining
    • siRNA

    ASJC Scopus subject areas

    • Molecular Biology
    • Cell Biology

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