A critical evaluation of neuroprotective and neurodegenerative MicroRNAs in Alzheimer's disease

P. Hemachandra Reddy, Sahil Tonk, Subodh Kumar, Murali Vijayan, Ramesh Kandimalla, Chandra Sekhar Kuruva, Arubala P. Reddy

    Research output: Contribution to journalReview article

    47 Scopus citations

    Abstract

    Currently, 5.4 million Americans suffer from AD, and these numbers are expected to increase up to 16 million by 2050. Despite tremendous research efforts, we still do not have drugs or agents that can delay, or prevent AD and its progression, and we still do not have early detectable biomarkers for AD. Multiple cellular changes have been implicated in AD, including synaptic damage, mitochondrial damage, production and accumulation of Aβ and phosphorylated tau, inflammatory response, deficits in neurotransmitters, deregulation of the cell cycle, and hormonal imbalance. Research into AD has revealed that miRNAs are involved in each of these cellular changes and interfere with gene regulation and translation. Recent discoveries in molecular biology have also revealed that microRNAs play a major role in post-translational regulation of gene expression. The purpose of this article is to review research that has assessed neuroprotective and neurodegenerative characteristics of microRNAs in brain samples from AD transgenic mouse models and patients with AD.

    Original languageEnglish (US)
    Pages (from-to)1156-1165
    Number of pages10
    JournalBiochemical and Biophysical Research Communications
    Volume483
    Issue number4
    DOIs
    StatePublished - Feb 19 2017

    Keywords

    • Alzheimer's disease
    • Mitochondrial dysfunction
    • Phosphorylated tau
    • Synaptic damage
    • microRNAs

    ASJC Scopus subject areas

    • Biophysics
    • Biochemistry
    • Molecular Biology
    • Cell Biology

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