A continuous regimen of levonorgestrel/ethinyl estradiol for contraception and elimination of menstruation

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Clinicians and patients desiring amenorrhea for therapeutic or social reasons will find continuous-use 90 μg levonorgestrel/20 μg ethinyl estradiol to be an attractive oral contraceptive dosing option. Although other formulations of oral contraceptives can be dosed in a continuous manner off-label, the convenience of a 28-day dose pack represents a major advance that will likely increase acceptability of the strategy. The availability of FDA-approved continuous-use 90 μg levonorgestrel/20 μg ethinyl estradiol will help mainstream continuous oral contraception in the same way that Preveri™ and Plan B® helped legitimize and mainstream emergency contraception. Patients wishing to use continuous 90 μg levonorgestrel/20 μg ethinyl estradiol must recognize and accept that unscheduled breakthrough bleeding is typical during the first four to six cycles of use. Control of cycle-related symptoms may emerge as an off-label indication for use.

Original languageEnglish (US)
Pages (from-to)183-195
Number of pages13
JournalDrugs of Today
Volume44
Issue number3
DOIs
StatePublished - Mar 1 2008

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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