A conserved Toll-like receptor is required for Caenorhabditis elegans innate immunity

Jennifer L. Tenor, Alejandro Aballay

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

Pathogen recognition through Toll-like receptors (TLRs) is crucial in order to mount an appropriate immune response against microorganisms. On the basis of a lack of evidence indicating that Caenorhabditis elegans uses TLRs to elicit an immune response and on the absence of genes encoding Rel-like transcription factors in its genome, it is believed that TLR-mediated immunity arose after coelomates split from pseudocoelomates and acoelomates. Here, we show that C. elegans tol-1(nr2033) mutants are killed by the human pathogen Salmonella enterica, which causes a significant pharyngeal invasion in the absence of TOL-1-mediated immunity. We also show that TOL-1 is required for the correct expression of ABF-2, which is a defensin-like molecule expressed in the pharynx, and heat-shock protein 16.41, which is also expressed in the pharynx and is part of a HSP family of proteins required for C. elegans immunity. The results indicate that TOL-1 has a direct role in defence response to certain Gram-negative bacteria and indicate that part of the TLR-mediated immunity might be evolutionarily conserved.

Original languageEnglish (US)
Pages (from-to)103-109
Number of pages7
JournalEMBO Reports
Volume9
Issue number1
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

Fingerprint

Toll-Like Receptors
Caenorhabditis elegans
Innate Immunity
Immunity
Pathogens
Pharynx
rel Genes
Caenorhabditis elegans Proteins
Defensins
Salmonella
Gene encoding
Salmonella enterica
Heat-Shock Proteins
Gram-Negative Bacteria
Microorganisms
Bacteria
Transcription Factors
Genes
Genome
Molecules

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

A conserved Toll-like receptor is required for Caenorhabditis elegans innate immunity. / Tenor, Jennifer L.; Aballay, Alejandro.

In: EMBO Reports, Vol. 9, No. 1, 01.01.2008, p. 103-109.

Research output: Contribution to journalArticle

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