A conjunctival lesion with histological features similar to large-cell acanthoma of the skin

Nicola G. Ghazi, Bina S. Patel, Leslie A. Olsakovsky, Kevin White, James W. Patterson, Bruce Carter

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Large-cell acanthoma (LCA) is a sharply demarcated epidermal lesion composed of large keratinocytes and characterized by hyperkeratosis, hypergranulosis and orthokeratosis. It usually affects actinically damaged skin. LCA is currently believed to be a distinct entity with an unclear pathogenesis and a benign biologic behavior. Here, we describe the first occurrence of LCA in the conjunctiva. The lesion recurred following initial excision, and later recurred as a carcinoma in situ following a second excision. This case suggests that LCA may have a malignant and transformation potential. Ghazi NG, Patel BS, Olsakovsky Leslie A, White K, Patterson JW. A conjunctival lesion with histological features similar to large-cell acanthoma of the skin.

Original languageEnglish (US)
Pages (from-to)1103-1106
Number of pages4
JournalJournal of Cutaneous Pathology
Volume37
Issue number10
DOIs
StatePublished - Oct 2010
Externally publishedYes

Fingerprint

Acanthoma
Skin
Conjunctiva
Carcinoma in Situ
Keratinocytes

ASJC Scopus subject areas

  • Dermatology
  • Pathology and Forensic Medicine
  • Histology

Cite this

A conjunctival lesion with histological features similar to large-cell acanthoma of the skin. / Ghazi, Nicola G.; Patel, Bina S.; Olsakovsky, Leslie A.; White, Kevin; Patterson, James W.; Carter, Bruce.

In: Journal of Cutaneous Pathology, Vol. 37, No. 10, 10.2010, p. 1103-1106.

Research output: Contribution to journalArticle

Ghazi, Nicola G. ; Patel, Bina S. ; Olsakovsky, Leslie A. ; White, Kevin ; Patterson, James W. ; Carter, Bruce. / A conjunctival lesion with histological features similar to large-cell acanthoma of the skin. In: Journal of Cutaneous Pathology. 2010 ; Vol. 37, No. 10. pp. 1103-1106.
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