Large-cell acanthoma (LCA) is a sharply demarcated epidermal lesion composed of large keratinocytes and characterized by hyperkeratosis, hypergranulosis and orthokeratosis. It usually affects actinically damaged skin. LCA is currently believed to be a distinct entity with an unclear pathogenesis and a benign biologic behavior. Here, we describe the first occurrence of LCA in the conjunctiva. The lesion recurred following initial excision, and later recurred as a carcinoma in situ following a second excision. This case suggests that LCA may have a malignant and transformation potential. Ghazi NG, Patel BS, Olsakovsky Leslie A, White K, Patterson JW. A conjunctival lesion with histological features similar to large-cell acanthoma of the skin.
ASJC Scopus subject areas
- Pathology and Forensic Medicine