A conjunctival lesion with histological features similar to large-cell acanthoma of the skin

Nicola G. Ghazi, Bina S. Patel, Leslie A. Olsakovsky, Kevin White, James W. Patterson, Bruce Carter

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Large-cell acanthoma (LCA) is a sharply demarcated epidermal lesion composed of large keratinocytes and characterized by hyperkeratosis, hypergranulosis and orthokeratosis. It usually affects actinically damaged skin. LCA is currently believed to be a distinct entity with an unclear pathogenesis and a benign biologic behavior. Here, we describe the first occurrence of LCA in the conjunctiva. The lesion recurred following initial excision, and later recurred as a carcinoma in situ following a second excision. This case suggests that LCA may have a malignant and transformation potential. Ghazi NG, Patel BS, Olsakovsky Leslie A, White K, Patterson JW. A conjunctival lesion with histological features similar to large-cell acanthoma of the skin.

Original languageEnglish (US)
Pages (from-to)1103-1106
Number of pages4
JournalJournal of cutaneous pathology
Volume37
Issue number10
DOIs
StatePublished - Oct 2010

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology

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