TY - JOUR
T1 - A conjunctival lesion with histological features similar to large-cell acanthoma of the skin
AU - Ghazi, Nicola G.
AU - Patel, Bina S.
AU - Olsakovsky, Leslie A.
AU - White, Kevin
AU - Patterson, James W.
AU - Carter, Bruce
N1 - Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 2010/10
Y1 - 2010/10
N2 - Large-cell acanthoma (LCA) is a sharply demarcated epidermal lesion composed of large keratinocytes and characterized by hyperkeratosis, hypergranulosis and orthokeratosis. It usually affects actinically damaged skin. LCA is currently believed to be a distinct entity with an unclear pathogenesis and a benign biologic behavior. Here, we describe the first occurrence of LCA in the conjunctiva. The lesion recurred following initial excision, and later recurred as a carcinoma in situ following a second excision. This case suggests that LCA may have a malignant and transformation potential. Ghazi NG, Patel BS, Olsakovsky Leslie A, White K, Patterson JW. A conjunctival lesion with histological features similar to large-cell acanthoma of the skin.
AB - Large-cell acanthoma (LCA) is a sharply demarcated epidermal lesion composed of large keratinocytes and characterized by hyperkeratosis, hypergranulosis and orthokeratosis. It usually affects actinically damaged skin. LCA is currently believed to be a distinct entity with an unclear pathogenesis and a benign biologic behavior. Here, we describe the first occurrence of LCA in the conjunctiva. The lesion recurred following initial excision, and later recurred as a carcinoma in situ following a second excision. This case suggests that LCA may have a malignant and transformation potential. Ghazi NG, Patel BS, Olsakovsky Leslie A, White K, Patterson JW. A conjunctival lesion with histological features similar to large-cell acanthoma of the skin.
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U2 - 10.1111/j.1600-0560.2009.01409.x
DO - 10.1111/j.1600-0560.2009.01409.x
M3 - Article
C2 - 19719831
AN - SCOPUS:77955697390
SN - 0303-6987
VL - 37
SP - 1103
EP - 1106
JO - Journal of cutaneous pathology
JF - Journal of cutaneous pathology
IS - 10
ER -