A conditioned stimulus decreases extracellular dopamine in the nucleus accumbens after the development of a learned taste aversion

G. P. Mark, D. S. Blander, B. G. Hoebel

Research output: Contribution to journalArticle

155 Scopus citations


The conditioned taste aversion (CTA) paradigm and microdialysis were used to determine if extracellular dopamine in the nucleus accumbens is related to the reward value of a stimulus. Intraorally applied saccharin caused a 37% increase in DA in naive rats and a 40% decrease in subjects with a CTA to this taste. These results suggest that accumbens DA is not just a function of arousal but is related to stimulus reward.

Original languageEnglish (US)
Pages (from-to)308-310
Number of pages3
JournalBrain research
Issue number1-2
StatePublished - Jun 14 1991



  • Conditioned taste aversion
  • Dopamine
  • Microdialysis
  • Nucleus accumbens

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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