A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals

Diana Herrera-Perez; Alyson Haslam; Tyler Crain; Jennifer Gill; Catherine Livingston; Victoria Kaestner; Michael Hayes; Dan Morgan; Adam S. Cifu; Vinay Prasad

doi:10.7554/eLife.48459

A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals

Diana Herrera-Perez, Alyson Haslam, Tyler Crain, Jennifer Gill, Catherine Livingston, Victoria Kaestner, Michael Hayes, Dan Morgan, Adam S. Cifu, Vinay Prasad

Knight Cancer Institute

Research output: Contribution to journal › Article

17 Scopus citations

Abstract

The ability to identify medical reversals and other low-value medical practices is an essential prerequisite for efforts to reduce spending on such practices. Through an analysis of more than 3000 randomized controlled trials (RCTs) published in three leading medical journals (the Journal of the American Medical Association, the Lancet, and the New England Journal of Medicine), we have identified 396 medical reversals. Most of the studies (92%) were conducted on populations in high- income countries, cardiovascular disease was the most common medical category (20%), and medication was the most common type of intervention (33%).

Original language	English (US)
Article number	e45183
Journal	eLife
Volume	8
DOIs	https://doi.org/10.7554/eLife.48459
State	Published - Jun 2019

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ASJC Scopus subject areas

Neuroscience(all)
Immunology and Microbiology(all)
Biochemistry, Genetics and Molecular Biology(all)

Cite this

Herrera-Perez, D., Haslam, A., Crain, T., Gill, J., Livingston, C., Kaestner, V., Hayes, M., Morgan, D., Cifu, A. S., & Prasad, V. (2019). A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals. eLife, 8, [e45183]. https://doi.org/10.7554/eLife.48459

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10.7554/eLife.48459