A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals

Diana Herrera-Perez, Alyson Haslam, Tyler Crain, Jennifer Gill, Catherine Livingston, Victoria Kaestner, Michael Hayes, Dan Morgan, Adam S. Cifu, Vinay Prasad

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The ability to identify medical reversals and other low-value medical practices is an essential prerequisite for efforts to reduce spending on such practices. Through an analysis of more than 3000 randomized controlled trials (RCTs) published in three leading medical journals (the Journal of the American Medical Association, the Lancet, and the New England Journal of Medicine), we have identified 396 medical reversals. Most of the studies (92%) were conducted on populations in high-income counties, cardiovascular disease was the most common medical category (20%), and medication was the most common type of intervention (33%).

Original languageEnglish (US)
JournaleLife
Volume8
DOIs
StatePublished - Jun 11 2019

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New England
American Medical Association
Medicine
Cardiovascular Diseases
Randomized Controlled Trials

Keywords

  • evidence-based medicine
  • human
  • low-value care
  • medical reversal

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals. / Herrera-Perez, Diana; Haslam, Alyson; Crain, Tyler; Gill, Jennifer; Livingston, Catherine; Kaestner, Victoria; Hayes, Michael; Morgan, Dan; Cifu, Adam S.; Prasad, Vinay.

In: eLife, Vol. 8, 11.06.2019.

Research output: Contribution to journalArticle

Herrera-Perez, D, Haslam, A, Crain, T, Gill, J, Livingston, C, Kaestner, V, Hayes, M, Morgan, D, Cifu, AS & Prasad, V 2019, 'A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals', eLife, vol. 8. https://doi.org/10.7554/eLife.45183
Herrera-Perez, Diana ; Haslam, Alyson ; Crain, Tyler ; Gill, Jennifer ; Livingston, Catherine ; Kaestner, Victoria ; Hayes, Michael ; Morgan, Dan ; Cifu, Adam S. ; Prasad, Vinay. / A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals. In: eLife. 2019 ; Vol. 8.
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