@article{c854f3dfa5794d799520c7500491fac3,
title = "A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals",
abstract = "The ability to identify medical reversals and other low-value medical practices is an essential prerequisite for efforts to reduce spending on such practices. Through an analysis of more than 3000 randomized controlled trials (RCTs) published in three leading medical journals (the Journal of the American Medical Association, the Lancet, and the New England Journal of Medicine), we have identified 396 medical reversals. Most of the studies (92%) were conducted on populations in high- income countries, cardiovascular disease was the most common medical category (20%), and medication was the most common type of intervention (33%).",
author = "Diana Herrera-Perez and Alyson Haslam and Tyler Crain and Jennifer Gill and Catherine Livingston and Victoria Kaestner and Michael Hayes and Dan Morgan and Cifu, {Adam S.} and Vinay Prasad",
note = "Funding Information: Author contributions: Diana Herrera-Perez, Conceptualization, Data curation, Formal analysis, Writing—original draft, Writing—review and editing; Alyson Haslam, Conceptualization, Data curation, Formal analysis, Methodology, Writing—original draft, Project administration, Writing—review and editing; Tyler Crain, Conceptualization, Data curation, Formal analysis, Methodology, Writing—original draft, Writing—review and editing; Jennifer Gill, Conceptualization, Data curation, Formal analysis, Methodology, Writing— review and editing; Catherine Livingston, Investigation, Writing—review and editing; Victoria Kaestner, Conceptualization, Data curation, Writing—review and editing; Michael Hayes, Dan Morgan, Adam S Cifu, Writing—review and editing; Vinay Prasad, Conceptualization, Data curation, Formal analysis, Supervision, Funding acquisition, Investigation, Methodology, Writing—original draft, Project administration, Writing— review and editing Competing interests: Adam S Cifu: ASC reports that he receives royalties from the book, Ending Medical Reversal. Vinay Prasad: VP reports that he receives royalties from his book Ending Medical Reversal; that his work is funded by the Laura and John Arnold Foundation; that he has received honoraria for Grand Rounds/ lectures from several universities, medical centers, nonprofit groups and professional societies; that he is a writer for Medscape; and that he hosts the podcast Plenary Session (which has Patreon Backers). The other authors declare that no competing interests exist.",
year = "2019",
month = jun,
doi = "10.7554/eLife.48459",
language = "English (US)",
volume = "8",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications",
}