A comprehensive excitatory input map of the striatum reveals novel functional organization

Barbara J. Hunnicutt, Bart C. Jongbloets, William T. Birdsong, Katrina J. Gertz, Haining Zhong, Tianyi Mao

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

The striatum integrates excitatory inputs from the cortex and the thalamus to control diverse functions. Although the striatum is thought to consist of sensorimotor, associative and limbic domains, their precise demarcations and whether additional functional subdivisions exist remain unclear. How striatal inputs are differentially segregated into each domain is also poorly understood. This study presents a comprehensive map of the excitatory inputs to the mouse striatum. The input patterns reveal boundaries between the known striatal domains. The most posterior striatum likely represents the 4th functional subdivision, and the dorsomedial striatum integrates highly heterogeneous, multimodal inputs. The complete thalamo-cortico-striatal loop is also presented, which reveals that the thalamic subregions innervated by the basal ganglia preferentially interconnect with motor-related cortical areas. Optogenetic experiments show the subregion-specific heterogeneity in the synaptic properties of striatal inputs from both the cortex and the thalamus. This projectome will guide functional studies investigating diverse striatal functions.

Original languageEnglish (US)
Article numbere19103
JournaleLife
Volume5
Issue numberNovember2016
DOIs
StatePublished - Nov 28 2016

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Corpus Striatum
Thalamus
Optogenetics
Basal Ganglia
Experiments

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Hunnicutt, B. J., Jongbloets, B. C., Birdsong, W. T., Gertz, K. J., Zhong, H., & Mao, T. (2016). A comprehensive excitatory input map of the striatum reveals novel functional organization. eLife, 5(November2016), [e19103]. https://doi.org/10.7554/eLife.19103

A comprehensive excitatory input map of the striatum reveals novel functional organization. / Hunnicutt, Barbara J.; Jongbloets, Bart C.; Birdsong, William T.; Gertz, Katrina J.; Zhong, Haining; Mao, Tianyi.

In: eLife, Vol. 5, No. November2016, e19103, 28.11.2016.

Research output: Contribution to journalArticle

Hunnicutt, BJ, Jongbloets, BC, Birdsong, WT, Gertz, KJ, Zhong, H & Mao, T 2016, 'A comprehensive excitatory input map of the striatum reveals novel functional organization', eLife, vol. 5, no. November2016, e19103. https://doi.org/10.7554/eLife.19103
Hunnicutt, Barbara J. ; Jongbloets, Bart C. ; Birdsong, William T. ; Gertz, Katrina J. ; Zhong, Haining ; Mao, Tianyi. / A comprehensive excitatory input map of the striatum reveals novel functional organization. In: eLife. 2016 ; Vol. 5, No. November2016.
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