A comparison of the effects of flurazepam on γ-aminobutyric acid mediated depression of cerebellar and cerebral cortical neurons

Zhi-Gen Jiang

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

With standard extracellular recording and microiontophoretic techniques, the effects of flurazepam on γ-aminobutyric acid (GABA) evoked depression of cerebellar and cerebral cortical neurons in rats have been studied. It was found that although flurazepam potentiated the GABA-mediated inhibition of most Purkinje cells (25 of 36), it caused only a weak potentiation of GABA action on some cerebral cortical neurons (14 of 37). The difference between the action of flurazepam in these two structures was statistically significant. The results confirm a previous report that the enhancement of GABA-evoked inhibition by benzodiazepines is more readily elicited on cerebellar cortical neurons than on cerebral cortical neurons.

Original languageEnglish (US)
Pages (from-to)595-598
Number of pages4
JournalCanadian Journal of Physiology and Pharmacology
Volume59
Issue number6
StatePublished - 1981
Externally publishedYes

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Flurazepam
Aminobutyrates
gamma-Aminobutyric Acid
Neurons
Purkinje Cells
Benzodiazepines

ASJC Scopus subject areas

  • Physiology
  • Pharmacology

Cite this

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