Abstract
With standard extracellular recording and microiontophoretic techniques, the effects of flurazepam on γ-aminobutyric acid (GABA) evoked depression of cerebellar and cerebral cortical neurons in rats have been studied. It was found that although flurazepam potentiated the GABA-mediated inhibition of most Purkinje cells (25 of 36), it caused only a weak potentiation of GABA action on some cerebral cortical neurons (14 of 37). The difference between the action of flurazepam in these two structures was statistically significant. The results confirm a previous report that the enhancement of GABA-evoked inhibition by benzodiazepines is more readily elicited on cerebellar cortical neurons than on cerebral cortical neurons.
Original language | English (US) |
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Pages (from-to) | 595-598 |
Number of pages | 4 |
Journal | Canadian Journal of Physiology and Pharmacology |
Volume | 59 |
Issue number | 6 |
DOIs | |
State | Published - 1981 |
Externally published | Yes |
ASJC Scopus subject areas
- Physiology
- Pharmacology
- Physiology (medical)