A comparison of the effects of central ν peripheral bolus injections of potassium chloride on aortic root potassium concentrations in swine

Mark S. Scheller, William J. Mazzei, Mark Zornow, Mark M. Mitchell

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Clinically relevant doses of potassium chloride (equivalent to 2 mEq/60 kg of body weight) were administered as rapid intravenous (IV) boluses to healthy halothane-anesthetized pigs. Potassium was given either peripherally through a standard IV ear catheter or centrally through the central venous port of a pulmonary artery catheter. Multiple injections were made in each pig, and cardiac output was varied by changing end-tidal halothane concentration. The aortic root potassium concentration was measured every three to six seconds for 90 seconds following potassium administration in each pig. Monitored variables included end-tidal halothane, end-tidal carbon dioxide, pulmonary artery pressure, mean arterial blood pressure, cardiac output, electrocardiogram, and temperature. Following both peripheral and central administration of potassium chloride, aortic root potassium increased significantly. However, the time required to achieve the peak aortic root potassium concentration was significantly less after central administration. In addition, the change in aortic root potassium concentration was greater following central administration compared with peripheral. The change in aortic root potassium concentration correlated inversely with cardiac ouput only after central, but not peripheral injection. Despite marked transient hyperkalemia in all animals, no electrocardiographic evidence of hyperkalemia could be demonstrated. It is concluded that small bolus doses of potassium chloride (2 mEq/60 kg) can be given safely either peripherally or centrally in normal, hemodynamically stable swine.

Original languageEnglish (US)
Pages (from-to)172-175
Number of pages4
JournalJournal of Cardiothoracic Anesthesia
Volume3
Issue number2
DOIs
StatePublished - 1989
Externally publishedYes

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Potassium Chloride
Potassium
Swine
Injections
Halothane
Hyperkalemia
Cardiac Output
Pulmonary Artery
Arterial Pressure
Catheters
Carbon Dioxide
Ear
Electrocardiography
Body Weight
Pressure
Temperature

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

A comparison of the effects of central ν peripheral bolus injections of potassium chloride on aortic root potassium concentrations in swine. / Scheller, Mark S.; Mazzei, William J.; Zornow, Mark; Mitchell, Mark M.

In: Journal of Cardiothoracic Anesthesia, Vol. 3, No. 2, 1989, p. 172-175.

Research output: Contribution to journalArticle

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