A comparison of the cerebral and haemodynamic effects of mannitol and hypertonic saline in an animal model of brain injury.

Mark Zornow, Y. S. Oh, M. S. Scheller

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

There has recently been an increased interest in the use of hypertonic saline solutions in the fluid resuscitation of trauma victims and to control intracranial hypertension. In this study, the cerebral and haemodynamic effects of a 3.2% hypertonic saline solution were compared with those of either a 0.9% saline or 20% solution were compared with those of either a 0.9% saline or 20% mannitol solution in a rabbit model of brain injury. Forty-five minutes following the creation of a left hemispheric cryogenic brain lesion, equal volumes of hypertonic saline, 0.9% saline, or mannitol were infused over a 5 minute period. Monitored variables over the ensuing 120 minutes included mean arterial pressure, central venous pressure, intracranial pressure, hematocrit, serum osmolality and oncotic pressure. Upon conclusion of the two hour study period, hemispheric water contents were determined by the wet/dry weight method. There were no significant differences in mean arterial pressure between the three groups at any point during the experiment. Plasma osmolality was significantly increased by 10-11 mOsm/kg in both the mannitol and hypertonic groups. The infusion of either mannitol or hypertonic saline produced a transient decrease in intracranial pressure lasting approximately 60 minutes whereas animals in the saline group demonstrated a continual increase in intracranial pressure. The lesioned hemisphere demonstrated a significantly greater water content than the non-lesioned hemisphere.

Original languageEnglish (US)
Pages (from-to)324-325
Number of pages2
JournalActa Neurochirurgica, Supplement
Volume51
StatePublished - 1990
Externally publishedYes

Fingerprint

Mannitol
Brain Injuries
Animal Models
Hemodynamics
Hypertonic Saline Solutions
Intracranial Hypertension
Intracranial Pressure
Osmolar Concentration
Arterial Pressure
Central Venous Pressure
Water
Hematocrit
Resuscitation
Rabbits
Pressure
Weights and Measures
Wounds and Injuries
Brain
Serum

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Neurology

Cite this

A comparison of the cerebral and haemodynamic effects of mannitol and hypertonic saline in an animal model of brain injury. / Zornow, Mark; Oh, Y. S.; Scheller, M. S.

In: Acta Neurochirurgica, Supplement, Vol. 51, 1990, p. 324-325.

Research output: Contribution to journalArticle

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