A comparison of surgical resection and liver transplantation in the treatment of intrahepatic cholangiocarcinoma in the era of modern chemotherapy: An analysis of the National Cancer Database

Jonathan J. Hue, Flavio G. Rocha, John B. Ammori, Jeffrey M. Hardacre, Luke D. Rothermel, Kenneth D. Chavin, Jordan M. Winter, Lee M. Ocuin

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Background: The main surgical approach to patients with localized intrahepatic cholangiocarcinoma (ICC) is hepatectomy, but transplantation has been described. A comparison of outcomes between these surgical approaches is necessary to determine if one is preferable. Methods: Patients with ICC were identified using the National Cancer Database (2010–2016). Patients were grouped based on operation and matched 1:1 by propensity score. Pathologic and postoperative outcomes, as well as overall survival were analyzed. Results: There were 1879 hepatectomy and 74 liver transplantation patients. Before matching, transplantation patients were younger and more often treated at academic centers. More patients who underwent a transplantation received neoadjuvant chemotherapy (70.3% vs. 12.8%). Patients who underwent transplantation had more pathologic T0 (7.7% vs. 0.4%) and T1 (47.7% vs. 42.1%) tumors (p <.001). There were no differences in length of stay, unplanned readmissions, 30/90-day mortality, or median survival between groups (36.1 vs. 36.1 months, p =.34). After matching (n = 57/group), there were no differences in postoperative outcomes or survival between transplantation or hepatectomy (36.1 vs. 33.6 months, p =.57). Conclusion: Among patients with ICC, hepatectomy and liver transplantation were associated with similar postoperative outcomes and survival. In light of the resources and chronic immunosuppression required for transplantation, hepatectomy seems preferable for localized ICC.

    Original languageEnglish (US)
    Pages (from-to)949-956
    Number of pages8
    JournalJournal of surgical oncology
    Volume123
    Issue number4
    DOIs
    StatePublished - Mar 15 2021

    Keywords

    • cholangiocarcinoma
    • hepatectomy
    • liver transplantation
    • survival analysis

    ASJC Scopus subject areas

    • Surgery
    • Oncology

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