A Comparison of IgG Antibody Reactive with Bacteroides forsythus and Porphyromonas gingivalis in Adult and Early-Onset Periodontitis

Joseph Califano, John C. Gunsolley, Harvey A. Schenkein, John G. Tew

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

RECENT WORK HAS INDICATED that Bacteroides forsythus and Porphyromonas gingivalis are significant local risk factors for periodontitis. Several reports find that both organisms are frequently associated with periodontitis lesions and often are present together. We have previously shown that early-onset periodontitis patients seropositive for P. gingivalis have less attachment loss than seronegative patients. In this study, we determined serum IgG antibody concentrations reactive with B. forsythus in adult and early-onset periodontitis patients using an ELISA and used P. gingivalis in the same populations as a positive control. The results for P. gingivalis were consistent with previous work and indicated that 47%, 36%, and 33% of adult, generalized early-onset, and localized juvenile patients were seropositive, respectively. Mean serum IgG concentrations for the three groups were 5.36 μg/ml, 5.65 μg/ml, 1, and 5.44 μg/ml for adult, generalized early-onset, and localized juvenile patients, respectively. In contrast, for B. forsythus only 11%, 14%, and 10% of adult, generalized early-onset, and localized juvenile patients were seropositive, with mean serum IgG concentrations of 0.46 μg/ml, 0.46 μg/ml, and 0.47 μg/ml, respectively. This suggests that B. forsythus is either poorly immunogenic or less invasive than P. gingivalis. If most patients fail to mount an immune response to B. forsythus and it is invasive, it may explain why this organism is a risk factor for disease.

Original languageEnglish (US)
Pages (from-to)734-738
Number of pages5
JournalJournal of Periodontology
Volume68
Issue number8
StatePublished - Aug 1997
Externally publishedYes

Fingerprint

Aggressive Periodontitis
Porphyromonas gingivalis
Immunoglobulin G
Antibodies
Periodontitis
Serum
Tannerella forsythia
Enzyme-Linked Immunosorbent Assay

Keywords

  • Antibodies, bacterial
  • Bacteroides forsythus
  • IgG
  • Periodontitis, early-onset/ microbiology
  • Porphyromonas gingivalis

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

A Comparison of IgG Antibody Reactive with Bacteroides forsythus and Porphyromonas gingivalis in Adult and Early-Onset Periodontitis. / Califano, Joseph; Gunsolley, John C.; Schenkein, Harvey A.; Tew, John G.

In: Journal of Periodontology, Vol. 68, No. 8, 08.1997, p. 734-738.

Research output: Contribution to journalArticle

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