A comparison of fenfluramine and amphetamine in man

John D. Griffith, John G. Nutt, Donald R. Jasinski

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

dl-Fenfluramine hydrochloride (60, 120, 240 mg), d-amphetamine sulfate (20, 40 mg), and placebo were compared in 8 postaddict volunteers, each dose given orally in random sequence at weekly intervals using a double-blind crossover design. Fenfluramine had little effect on blood pressure and temperature, but caused a marked dilation of pupils, whereas amphetamine was a potent vasopressor and a weak mydriatic. While fenfluramine produced euphoria in some subjects, its overall effects were unpleasant, sedative, and qualitatively different from amphetamine. Three subjects given 240 mg of fenfluramine experienced brief but vivid hallucinogenic episodes characterized by olfactory, visual, and somatic hallucinations, abrupt polar changes in mood, time distortion, fleeting paranoia, and sexual ideation. These observations indicate that fenfluramine is a hallucinogenic agent with a pharmacologic profile in man that is not amphetamine-like.

Original languageEnglish (US)
Pages (from-to)563-570
Number of pages8
JournalClinical pharmacology and therapeutics
Volume18
Issue number5 PART 1
DOIs
StatePublished - Nov 1975

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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