A comparison of CT scan to transrcctal ultrasound measured prostate volume in untreated prostate cancer

S. Christopher Hoffelt, Mark Ganotto, Arthur Hung, John Holland

Research output: Contribution to journalArticle

Abstract

Purpose: To compare CT and TRUS measured prostate volumes in patients with untreated prostate cancer. Methods and Materials: From 1995 to 1999, 48 consecutive patients with prostate adenocarcinoma were treated with external beam radiation at the Portland Veterans Administration Hospital. In 36 of these patients. Transrectal Ultrasound (TRUS) and CT measurements of prostate volume were obtained prior to treatment, fewer than 6 months apart. TRUS volume was calculated using the prolate ellipsoid formula. CT volume was calculated from contours of the prostate drawn by one physician on axial CT images obtained at 3 or 5 mm intervals. The physician was blinded to the TRUS volume. Results: TRUS and CT prostate volume measurements strongly correlated (Pearson's correlation coefficient = 0.925, 95%CI 0.856-0.961, P <0.0001). CT volume was consistently larger than TRUS volume by a factor of approximately 1.5. When grouped into quartiles by TRUS volume, the overestimation of prostate volume by CT was greatest for prostate volumes less than 22.1 cubic centimeters (r = 0.410, 95%CI 0.094-0.651, P = 0.0123). CT volumes were similarly correlated with TRUS volumes regardless of CT slice interval (3mm: r = 0.866, 95% Cl 0.601-0.959, n = 13; 5mm: r = 0.930 95%CI 0.840-0.970, n = 23). The CT slice interval had no effect on the ratio between CT and US volume. Conclusion: There is a strong correlation between CT scan and TRUS measurement of prostate volume. CT scan overestimates prostate volume by approximately fifty percent.

Original languageEnglish (US)
Pages (from-to)504
Number of pages1
JournalCancer Journal
Volume9
Issue number6
StatePublished - 1996

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Cone-Beam Computed Tomography
Prostate
Prostatic Neoplasms
Phosmet
Physicians
Veterans Hospitals
United States Department of Veterans Affairs
Adenocarcinoma
Radiation

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

A comparison of CT scan to transrcctal ultrasound measured prostate volume in untreated prostate cancer. / Christopher Hoffelt, S.; Ganotto, Mark; Hung, Arthur; Holland, John.

In: Cancer Journal, Vol. 9, No. 6, 1996, p. 504.

Research output: Contribution to journalArticle

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abstract = "Purpose: To compare CT and TRUS measured prostate volumes in patients with untreated prostate cancer. Methods and Materials: From 1995 to 1999, 48 consecutive patients with prostate adenocarcinoma were treated with external beam radiation at the Portland Veterans Administration Hospital. In 36 of these patients. Transrectal Ultrasound (TRUS) and CT measurements of prostate volume were obtained prior to treatment, fewer than 6 months apart. TRUS volume was calculated using the prolate ellipsoid formula. CT volume was calculated from contours of the prostate drawn by one physician on axial CT images obtained at 3 or 5 mm intervals. The physician was blinded to the TRUS volume. Results: TRUS and CT prostate volume measurements strongly correlated (Pearson's correlation coefficient = 0.925, 95{\%}CI 0.856-0.961, P <0.0001). CT volume was consistently larger than TRUS volume by a factor of approximately 1.5. When grouped into quartiles by TRUS volume, the overestimation of prostate volume by CT was greatest for prostate volumes less than 22.1 cubic centimeters (r = 0.410, 95{\%}CI 0.094-0.651, P = 0.0123). CT volumes were similarly correlated with TRUS volumes regardless of CT slice interval (3mm: r = 0.866, 95{\%} Cl 0.601-0.959, n = 13; 5mm: r = 0.930 95{\%}CI 0.840-0.970, n = 23). The CT slice interval had no effect on the ratio between CT and US volume. Conclusion: There is a strong correlation between CT scan and TRUS measurement of prostate volume. CT scan overestimates prostate volume by approximately fifty percent.",
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