Abstract
UFT or 5'-DFUR was orally administered to the patients with hepatocellular carcinoma preoperatively and the concentrations of these drugs and 5-FU in the serum, liver tissue and cancer tissue obtained at the time of operation were measured. The unchanged 5'-DFUR was not detected in any of these samples. The concentration of 5-FU in cancer tissue was significantly higher in UFT treated group (0.409 μg/g) than that in 5'-DFUR group (0.040 μg/g). However, the 5-FU levels in the serum and noncancerous liver tissue were also higher than those in the patients with other organ cancers. Although UFT is a useful drug for the adjuvant chemotherapy of hepatocellular carcinoma, the dose was considered to be minimized to avoid the side effects since the activity of drug-metabolizing enzymes may be decreased in hepatocellular carcinoma complicated with liver cirrhosis.
Original language | English (US) |
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Pages (from-to) | 641-645 |
Number of pages | 5 |
Journal | Japanese Journal of Cancer and Chemotherapy |
Volume | 21 |
Issue number | 5 |
State | Published - 1994 |
Externally published | Yes |
Keywords
- 5'-DFUR
- UFT
- adjuvant chemotherapy
- hepatocellular carcinoma with liver cirrhosis
ASJC Scopus subject areas
- Oncology
- Cancer Research