A comparative study on the serum and tissue 5-FU concentrations in the patients with hepatocellular carcinoma after preoperative oral administration of UFT and 5'-DFUR

K. Miyazaki, H. Yakushiji, K. Kitahara, M. Mori, E. Sasatomi, N. Tsutsumi, Y. Hirobashi, A. Iwanaga, A. Iyama, H. Fukagawa, T. Hisatsugu

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

UFT or 5'-DFUR was orally administered to the patients with hepatocellular carcinoma preoperatively and the concentrations of these drugs and 5-FU in the serum, liver tissue and cancer tissue obtained at the time of operation were measured. The unchanged 5'-DFUR was not detected in any of these samples. The concentration of 5-FU in cancer tissue was significantly higher in UFT treated group (0.409 μg/g) than that in 5'-DFUR group (0.040 μg/g). However, the 5-FU levels in the serum and noncancerous liver tissue were also higher than those in the patients with other organ cancers. Although UFT is a useful drug for the adjuvant chemotherapy of hepatocellular carcinoma, the dose was considered to be minimized to avoid the side effects since the activity of drug-metabolizing enzymes may be decreased in hepatocellular carcinoma complicated with liver cirrhosis.

Original languageEnglish (US)
Pages (from-to)641-645
Number of pages5
JournalJapanese Journal of Cancer and Chemotherapy
Volume21
Issue number5
StatePublished - 1994
Externally publishedYes

Keywords

  • 5'-DFUR
  • adjuvant chemotherapy
  • hepatocellular carcinoma with liver cirrhosis
  • UFT

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'A comparative study on the serum and tissue 5-FU concentrations in the patients with hepatocellular carcinoma after preoperative oral administration of UFT and 5'-DFUR'. Together they form a unique fingerprint.

Cite this