A comparative study of three-dimensional printing directions: The degradation and toxicological profile of a PLA/PHA blend

Jennifer Gonzalez Ausejo, Joanna Rydz, Marta Musioł, Wanda Sikorska, Michał Sobota, Jakub Włodarczyk, Grażyna Adamus, Henryk Janeczek, Iwona Kwiecień, Anna Hercog, Brian Johnston, Habib R. Khan, Vinodh Kannappan, Keith R. Jones, Mark R. Morris, Gouzhan Jiang, Iza Radecka, Marek Kowalczuk

Research output: Contribution to journalArticle

  • 2 Citations

Abstract

The use of biobased plastics is of great importance for many applications. Blending thermoplastic polylactide (PLA) with polyhydroxyalkanoate (PHA) enables the formulation of a more mechanically powerful material and this enables tailored biodegradation properties. In this study we demonstrate the 3D printing of a PLA/PHA blend as a potential candidate for biocompatible material applications. The filament for 3D printing consisted of PHA, which contains predominantly 3-hydroxybutyrate units and a small amount of 3-hydroxyvalerate units, as revealed by multistage mass spectrometry (ESI-MSn). This research found that the properties of 3D printed species before and during abiotic degradation are dependent on printing orientation. Furthermore, the 3D printed specimens exhibited good biocompatibility with HEK293 cells, indicating real promise as biological scaffolds for tissue engineering applications.

LanguageEnglish (US)
Pages191-207
Number of pages17
JournalPolymer Degradation and Stability
Volume152
DOIs
StatePublished - Jun 1 2018
Externally publishedYes

Fingerprint

3D printers
Polyhydroxyalkanoates
printing
Printing
degradation
Degradation
profiles
biodegradation
3-Hydroxybutyric Acid
tissue engineering
Biocompatible Materials
biocompatibility
Scaffolds (biology)
Biodegradation
Biocompatibility
Tissue engineering
Biomaterials
Thermoplastics
Mass spectrometry
filaments

Keywords

  • (bio)degradable polyester
  • Cell proliferation
  • Degradation
  • Layer orientation
  • Three-dimensional printing
  • Toxicity test

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Mechanics of Materials
  • Polymers and Plastics
  • Materials Chemistry

Cite this

A comparative study of three-dimensional printing directions : The degradation and toxicological profile of a PLA/PHA blend. / Gonzalez Ausejo, Jennifer; Rydz, Joanna; Musioł, Marta; Sikorska, Wanda; Sobota, Michał; Włodarczyk, Jakub; Adamus, Grażyna; Janeczek, Henryk; Kwiecień, Iwona; Hercog, Anna; Johnston, Brian; Khan, Habib R.; Kannappan, Vinodh; Jones, Keith R.; Morris, Mark R.; Jiang, Gouzhan; Radecka, Iza; Kowalczuk, Marek.

In: Polymer Degradation and Stability, Vol. 152, 01.06.2018, p. 191-207.

Research output: Contribution to journalArticle

Gonzalez Ausejo, J, Rydz, J, Musioł, M, Sikorska, W, Sobota, M, Włodarczyk, J, Adamus, G, Janeczek, H, Kwiecień, I, Hercog, A, Johnston, B, Khan, HR, Kannappan, V, Jones, KR, Morris, MR, Jiang, G, Radecka, I & Kowalczuk, M 2018, 'A comparative study of three-dimensional printing directions: The degradation and toxicological profile of a PLA/PHA blend' Polymer Degradation and Stability, vol. 152, pp. 191-207. https://doi.org/10.1016/j.polymdegradstab.2018.04.024
Gonzalez Ausejo, Jennifer ; Rydz, Joanna ; Musioł, Marta ; Sikorska, Wanda ; Sobota, Michał ; Włodarczyk, Jakub ; Adamus, Grażyna ; Janeczek, Henryk ; Kwiecień, Iwona ; Hercog, Anna ; Johnston, Brian ; Khan, Habib R. ; Kannappan, Vinodh ; Jones, Keith R. ; Morris, Mark R. ; Jiang, Gouzhan ; Radecka, Iza ; Kowalczuk, Marek. / A comparative study of three-dimensional printing directions : The degradation and toxicological profile of a PLA/PHA blend. In: Polymer Degradation and Stability. 2018 ; Vol. 152. pp. 191-207.
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