A community-based outbreak of severe respiratory illness caused by human adenovirus serotype 14

Paul Lewis, Mark A. Schmidt, Xiaoyan Lu, Dean D. Erdman, Mary Campbell, Ann Thomas, Paul R. Cieslak, La Donna Grenz, Laura Tsaknardis, Curt Gleaves, Brian Kendall, David Gilbert

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

Background. Human adenoviruses (Ads) typically cause mild illnesses in otherwise healthy hosts. We investigated a community-based outbreak that had substantial morbidity caused primarily by Ad14, an uncommon serotype. Methods. We retrospectively reviewed the medical records of all patients with confirmed cases of Ad infection from 1 November 2006 through 31 July 2007 in Oregon. Isolates were typed by sequencing. We analyzed clinical and laboratory variables to identify risk factors for severe Ad14 disease. Results. Ad14 first emerged in Oregon in 2005. Of 67 cases of Ad infection detected during the study period, 40 (60%) involved Ad14. Most of the 38 Ad14-infected patients who had medical records available for review presented with fever and cough; 29 (76%) required hospitalization, 23 (61%) required supplemental oxygen, 18 (47%) required critical care, 9 (24%) required vasopressors, and 7 (18%) died. Lobar infiltrates on chest radiographs suggestive of bacterial pneumonia were common among those needing hospitalization. Older age, chronic underlying condition, low absolute lymphocyte counts, and elevated creatinine levels were associated with severe illness. Except for 1 case of possible hospital transmission, we identified no epidemiological links among patients. Conclusion. Ad14 emerged in Oregon in 2005 and became the predominant circulating type by 2007. Infection with this uncommon virus was primarily associated with a community-acquired pneumonia syndrome and caused substantial morbidity and mortality.

Original languageEnglish (US)
Pages (from-to)1427-1434
Number of pages8
JournalJournal of Infectious Diseases
Volume199
Issue number10
DOIs
StatePublished - May 15 2009

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Human Adenoviruses
Disease Outbreaks
Medical Records
Hospitalization
Infection
Morbidity
Bacterial Pneumonia
Lymphocyte Count
Critical Care
Cough
Creatinine
Pneumonia
Fever
Thorax
Oxygen
Viruses
Mortality
Serogroup

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

Cite this

Lewis, P., Schmidt, M. A., Lu, X., Erdman, D. D., Campbell, M., Thomas, A., ... Gilbert, D. (2009). A community-based outbreak of severe respiratory illness caused by human adenovirus serotype 14. Journal of Infectious Diseases, 199(10), 1427-1434. https://doi.org/10.1086/598521

A community-based outbreak of severe respiratory illness caused by human adenovirus serotype 14. / Lewis, Paul; Schmidt, Mark A.; Lu, Xiaoyan; Erdman, Dean D.; Campbell, Mary; Thomas, Ann; Cieslak, Paul R.; Grenz, La Donna; Tsaknardis, Laura; Gleaves, Curt; Kendall, Brian; Gilbert, David.

In: Journal of Infectious Diseases, Vol. 199, No. 10, 15.05.2009, p. 1427-1434.

Research output: Contribution to journalArticle

Lewis, P, Schmidt, MA, Lu, X, Erdman, DD, Campbell, M, Thomas, A, Cieslak, PR, Grenz, LD, Tsaknardis, L, Gleaves, C, Kendall, B & Gilbert, D 2009, 'A community-based outbreak of severe respiratory illness caused by human adenovirus serotype 14', Journal of Infectious Diseases, vol. 199, no. 10, pp. 1427-1434. https://doi.org/10.1086/598521
Lewis, Paul ; Schmidt, Mark A. ; Lu, Xiaoyan ; Erdman, Dean D. ; Campbell, Mary ; Thomas, Ann ; Cieslak, Paul R. ; Grenz, La Donna ; Tsaknardis, Laura ; Gleaves, Curt ; Kendall, Brian ; Gilbert, David. / A community-based outbreak of severe respiratory illness caused by human adenovirus serotype 14. In: Journal of Infectious Diseases. 2009 ; Vol. 199, No. 10. pp. 1427-1434.
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