A common site for immortalizing proviral integrations in Friend erythroleukemia: Molecular cloning and characterization

R. Paul, S. Schuetze, S. L. Kozak, D. Kabat

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

By using a tagged derivative of Friend spleen focus-forming virus, we previously obtained evidence that proviral integration(s) in the host genome can cause erythroblast immortality by abrogating the commitment of the cell to differentiate (C. Spiro, B. Gliniak, and D. Kabat, J. Virol. 62: 4129-4135, 1988). Exploiting the fact that each leukemia was a single clone that contained one tagged provirus, we have now molecularly cloned and characterized one common genomic site for immortalizing proviral integrations.

Original languageEnglish (US)
Pages (from-to)4958-4961
Number of pages4
JournalJournal of virology
Volume63
Issue number11
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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