A cholinergic mechanism involved in fetal breathing during the high voltage ECoG state

John M. Bissonnette, Alan (Roger) Hohimer, Sharon J. Knopp

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The effects of muscarininc cholinergic neurotransmission on fetal breathing was determined by administration of carbachol or carbachol plus a muscarinic receptor antagonist into the cerebrospinal fluid of the fourth ventricle in unanesthetized fetal sheep. In the hour following the instillation of carbachol (1.0 μg), the incidence of fetal breathing in high voltage electrocortical state (ECoG) increased to 63 ± 11.7 (SEM) percent compared to 1.2 ± 0.9 after instillation of vehicle (Ringer solution). The cholinergic agonist increased breath amplitude from 4.5 ± 0.4 to 10.6 ± 1.4 mmHg. These effects were eliminated when the M1 receptor antagonist pirenzipine (50-100 μg) was administered with carbachol but not by antagonists which are relatively selective for M2 or M3 receptors. When administered alone, muscarinic receptor antagonists did not effect the incidence or amplitude of fetal breathing in low voltage. These data indicate that the apnea which occurs during high voltage in the sheep fetus involves an inhibition of acetylcholine acting at M1 muscarinic receptor bearing neurons.

Original languageEnglish (US)
Pages (from-to)151-162
Number of pages12
JournalRespiration Physiology
Volume96
Issue number2-3
DOIs
StatePublished - 1994

Fingerprint

Carbachol
Cholinergic Agents
Respiration
Muscarinic Antagonists
Muscarinic Receptors
Sheep
Muscarinic M1 Receptors
Fourth Ventricle
Cholinergic Agonists
Incidence
Apnea
Synaptic Transmission
Acetylcholine
Cerebrospinal Fluid
Fetus
Neurons

Keywords

  • control of breathing, sleep, central mediators (fetal sheep)
  • Fetal breathing sheep, muscarinic effects
  • Mammals, sheep (fetal)
  • Mediators, central, acetylcholine, fetal breathing
  • Sheep, fetal breathing, central mediators

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

Cite this

A cholinergic mechanism involved in fetal breathing during the high voltage ECoG state. / Bissonnette, John M.; Hohimer, Alan (Roger); J. Knopp, Sharon.

In: Respiration Physiology, Vol. 96, No. 2-3, 1994, p. 151-162.

Research output: Contribution to journalArticle

Bissonnette, John M. ; Hohimer, Alan (Roger) ; J. Knopp, Sharon. / A cholinergic mechanism involved in fetal breathing during the high voltage ECoG state. In: Respiration Physiology. 1994 ; Vol. 96, No. 2-3. pp. 151-162.
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