A chicken embryo cardiac outflow tract atlas for registering changes due to abnormal blood flow

James P. Carson, Monique Y. Rennie, Michael Danilchik, Kent Thornburg, Sandra Rugonyi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Subdivision-based image registration has previously been applied to co-localize digital information extracted from rigid structures in biological specimens, such as the brain. Here, we describe and demonstrate the creation and application of a two-dimensional subdivision-based atlas representing a dynamic structure: the outflow tract of the developing chicken heart. The atlas is designed to segment three different anatomical layers of the outflow tract, and is demonstrated on the characterization of collagen XIV in both control and induced abnormal flow specimens. Abnormal blood flow in the embryonic developing heart can lead to congenital heart disease. Comparing local cellular and sub-cellular changes that are caused by abnormal flow can assist in understanding the molecular pathways involved in maladaptations of the heart and congenital defects. This study demonstrates the approach and potential for more extensive applications of the subdivision-based atlas for the embryonic chicken heart.

Original languageEnglish (US)
Title of host publication2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1236-1239
Number of pages4
ISBN (Electronic)9781457702204
DOIs
StatePublished - Oct 13 2016
Event38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 - Orlando, United States
Duration: Aug 16 2016Aug 20 2016

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volume2016-October
ISSN (Print)1557-170X

Other

Other38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
CountryUnited States
CityOrlando
Period8/16/168/20/16

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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  • Cite this

    Carson, J. P., Rennie, M. Y., Danilchik, M., Thornburg, K., & Rugonyi, S. (2016). A chicken embryo cardiac outflow tract atlas for registering changes due to abnormal blood flow. In 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 (pp. 1236-1239). [7590929] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2016-October). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2016.7590929