A cell-permeable synthetic transcription factor mimic

Xiangshu Xiao, Peng Yu, Hyun Suk Lim, Devanjan Sikder, Thomas Kodadek

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Do you copy? A cell-permeable synthetic transcription factor mimic composed of a DNA-binding hairpin polyamide and an activation-domain-like peptoid can turn on gene transcription in living cells. (Figure Presented).

Original languageEnglish (US)
Pages (from-to)2865-2868
Number of pages4
JournalAngewandte Chemie - International Edition
Volume46
Issue number16
DOIs
StatePublished - 2007
Externally publishedYes

Fingerprint

Peptoids
Transcription factors
Nylons
Transcription
Polyamides
DNA
Transcription Factors
Genes
Chemical activation
Cells

Keywords

  • DNA
  • DNA transcription
  • Ligands
  • Peptoids
  • Polyamides

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

A cell-permeable synthetic transcription factor mimic. / Xiao, Xiangshu; Yu, Peng; Lim, Hyun Suk; Sikder, Devanjan; Kodadek, Thomas.

In: Angewandte Chemie - International Edition, Vol. 46, No. 16, 2007, p. 2865-2868.

Research output: Contribution to journalArticle

Xiao, Xiangshu ; Yu, Peng ; Lim, Hyun Suk ; Sikder, Devanjan ; Kodadek, Thomas. / A cell-permeable synthetic transcription factor mimic. In: Angewandte Chemie - International Edition. 2007 ; Vol. 46, No. 16. pp. 2865-2868.
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