A case-control study of risk factors for fibrocystic breast conditions: Shanghai nutrition and breast disease study, China, 1995-2000

Chunyuan Wu, Roberta M. Ray, Ming Gang Lin, Dao Li Gao, Neilann K. Horner, Zakia C. Nelson, Johanna W. Lampe, Yong Wei Hu, Jackilen (Jackie) Shannon, Helge Stalsberg, Wenjin Li, Dawn Fitzgibbons, Peggy Porter, Ruth E. Patterson, Jessie A. Satia, David B. Thomas

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

This study was conducted to identify reproductive and dietary factors associated with benign proliferative mammary epithelial cell changes. Subjects were women enrolled in a randomized trial of breast self-examination in Shanghai, China. Women who developed fibrocystic breast conditions classified as nonproliferative (175 women), proliferative (181 women), or proliferative with atypia (33 women) between 1995 and 2000 and 1,070 unaffected trial participants were administered general risk factor and food frequency questionnaires. Conditional logistic regression was used to estimate adjusted odds ratios and 95% confidence intervals. High parity and consumption of fresh fruits and vegetables were more strongly associated with a reduced risk of proliferative and atypical lesions than with nonproliferative conditions. For the fourth quartile of consumption versus the first, odds ratios for lesions diagnosed as nonproliferative, proliferative, and proliferative with atypia were 0.4 (95% confidence interval (CI): 0.2, 0.7), 0.2 (95% CI: 0.1, 0.4), and 0.1 (95% CI: 0.03, 0.5), respectively, for fruit intake and 0.6 (95% CI: 0.3, 1.1), 0.4 (95% CI: 0.2, 0.7), and 0.1 (95% CI: 0.1, 0.9), respectively, for vegetable intake. Reduced but nonsignificant risks in relation to soy products were observed for proliferative and atypical lesions. No single nutrient or botanical family was appreciably more strongly associated with proliferative conditions than with nonproliferative conditions, after results were controlled for total fruit and vegetable consumption. A diet rich in fruits and vegetables may reduce cellular proliferation in the mammary epithelium; this is one mechanism by which such a diet could reduce risk of breast cancer.

Original languageEnglish (US)
Pages (from-to)945-960
Number of pages16
JournalAmerican Journal of Epidemiology
Volume160
Issue number10
DOIs
StatePublished - Nov 15 2004
Externally publishedYes

Fingerprint

Breast Diseases
Case-Control Studies
China
Breast
Confidence Intervals
Vegetables
Fruit
Odds Ratio
Breast Self-Examination
Diet
Food
Parity
Epithelium
Logistic Models
Epithelial Cells
Cell Proliferation
Breast Neoplasms

Keywords

  • Breast diseases
  • Diet
  • Estrogens
  • Fibrocystic disease of breast
  • Fruit
  • Risk factors
  • Soy foods
  • Vegetables

ASJC Scopus subject areas

  • Epidemiology

Cite this

A case-control study of risk factors for fibrocystic breast conditions : Shanghai nutrition and breast disease study, China, 1995-2000. / Wu, Chunyuan; Ray, Roberta M.; Lin, Ming Gang; Gao, Dao Li; Horner, Neilann K.; Nelson, Zakia C.; Lampe, Johanna W.; Hu, Yong Wei; Shannon, Jackilen (Jackie); Stalsberg, Helge; Li, Wenjin; Fitzgibbons, Dawn; Porter, Peggy; Patterson, Ruth E.; Satia, Jessie A.; Thomas, David B.

In: American Journal of Epidemiology, Vol. 160, No. 10, 15.11.2004, p. 945-960.

Research output: Contribution to journalArticle

Wu, C, Ray, RM, Lin, MG, Gao, DL, Horner, NK, Nelson, ZC, Lampe, JW, Hu, YW, Shannon, JJ, Stalsberg, H, Li, W, Fitzgibbons, D, Porter, P, Patterson, RE, Satia, JA & Thomas, DB 2004, 'A case-control study of risk factors for fibrocystic breast conditions: Shanghai nutrition and breast disease study, China, 1995-2000', American Journal of Epidemiology, vol. 160, no. 10, pp. 945-960. https://doi.org/10.1093/aje/kwh318
Wu, Chunyuan ; Ray, Roberta M. ; Lin, Ming Gang ; Gao, Dao Li ; Horner, Neilann K. ; Nelson, Zakia C. ; Lampe, Johanna W. ; Hu, Yong Wei ; Shannon, Jackilen (Jackie) ; Stalsberg, Helge ; Li, Wenjin ; Fitzgibbons, Dawn ; Porter, Peggy ; Patterson, Ruth E. ; Satia, Jessie A. ; Thomas, David B. / A case-control study of risk factors for fibrocystic breast conditions : Shanghai nutrition and breast disease study, China, 1995-2000. In: American Journal of Epidemiology. 2004 ; Vol. 160, No. 10. pp. 945-960.
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abstract = "This study was conducted to identify reproductive and dietary factors associated with benign proliferative mammary epithelial cell changes. Subjects were women enrolled in a randomized trial of breast self-examination in Shanghai, China. Women who developed fibrocystic breast conditions classified as nonproliferative (175 women), proliferative (181 women), or proliferative with atypia (33 women) between 1995 and 2000 and 1,070 unaffected trial participants were administered general risk factor and food frequency questionnaires. Conditional logistic regression was used to estimate adjusted odds ratios and 95{\%} confidence intervals. High parity and consumption of fresh fruits and vegetables were more strongly associated with a reduced risk of proliferative and atypical lesions than with nonproliferative conditions. For the fourth quartile of consumption versus the first, odds ratios for lesions diagnosed as nonproliferative, proliferative, and proliferative with atypia were 0.4 (95{\%} confidence interval (CI): 0.2, 0.7), 0.2 (95{\%} CI: 0.1, 0.4), and 0.1 (95{\%} CI: 0.03, 0.5), respectively, for fruit intake and 0.6 (95{\%} CI: 0.3, 1.1), 0.4 (95{\%} CI: 0.2, 0.7), and 0.1 (95{\%} CI: 0.1, 0.9), respectively, for vegetable intake. Reduced but nonsignificant risks in relation to soy products were observed for proliferative and atypical lesions. No single nutrient or botanical family was appreciably more strongly associated with proliferative conditions than with nonproliferative conditions, after results were controlled for total fruit and vegetable consumption. A diet rich in fruits and vegetables may reduce cellular proliferation in the mammary epithelium; this is one mechanism by which such a diet could reduce risk of breast cancer.",
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