Abstract
Background: The Questionnaire of Olfactory Disorders‒Negative Statements (QOD-NS) is a valuable instrument in the measurement of olfactory-specific quality of life (QOL). In the clinical setting, patients can be overwhelmed with the time required to complete questionnaires. Our objective was to develop a brief version of the QOD-NS to streamline clinical care and research. Methods: QOD-NS scores from 221 subjects were used to determine which subset of the 17 QOD-NS questions best correlated with total and subdomain QOD-NS scores. An initial pool of 11 questions was made by removing items with ρ < 0.80 to their respective subdomain scores. Next, 500 bootstrapped samples were taken. On each sampe, an all-subsets regression was performed with total QOD-NS scores and QOD-NS subdomain scores as the outcomes. From this, our “top” and “bottom” 10 subsets were identified based on mean r2 value, representation in bootstrap analysis, and number of items. Results: All of our top subsets had excellent correlation with total and subdomain QOD-NS scores (mean r2 > 0.90). Our top choice has 7 total questions, is representative of all subdomains, has a mean r2 = 0.92, and was represented in 323 of our 500 bootstrapped samples. The worst-performing subset has 5 items, mean r2 = 0.81, and was represented in only 1 bootstrapped sample. Conclusions: Using less than half of the questions in the QOD-NS, excellent correlations with both total and domain-specific scores are achieved. A brief version of the QOD-NS may prove useful in future clinical and research settings.
| Original language | English (US) |
|---|---|
| Journal | International Forum of Allergy and Rhinology |
| DOIs | |
| State | Accepted/In press - Jan 1 2019 |
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Keywords
- olfaction
- quality of life
- questionnaire of olfactory disorders
- sinusitis
- smell
ASJC Scopus subject areas
- Immunology and Allergy
- Otorhinolaryngology
Cite this
A brief version of the questionnaire of olfactory disorders in patients with chronic rhinosinusitis. / Mattos, Jose L.; Edwards, Campbell; Schlosser, Rodney J.; Hyer, Madison; Mace, Jess C.; Smith, Timothy; Soler, Zachary M.
In: International Forum of Allergy and Rhinology, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A brief version of the questionnaire of olfactory disorders in patients with chronic rhinosinusitis
AU - Mattos, Jose L.
AU - Edwards, Campbell
AU - Schlosser, Rodney J.
AU - Hyer, Madison
AU - Mace, Jess C.
AU - Smith, Timothy
AU - Soler, Zachary M.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background: The Questionnaire of Olfactory Disorders‒Negative Statements (QOD-NS) is a valuable instrument in the measurement of olfactory-specific quality of life (QOL). In the clinical setting, patients can be overwhelmed with the time required to complete questionnaires. Our objective was to develop a brief version of the QOD-NS to streamline clinical care and research. Methods: QOD-NS scores from 221 subjects were used to determine which subset of the 17 QOD-NS questions best correlated with total and subdomain QOD-NS scores. An initial pool of 11 questions was made by removing items with ρ < 0.80 to their respective subdomain scores. Next, 500 bootstrapped samples were taken. On each sampe, an all-subsets regression was performed with total QOD-NS scores and QOD-NS subdomain scores as the outcomes. From this, our “top” and “bottom” 10 subsets were identified based on mean r2 value, representation in bootstrap analysis, and number of items. Results: All of our top subsets had excellent correlation with total and subdomain QOD-NS scores (mean r2 > 0.90). Our top choice has 7 total questions, is representative of all subdomains, has a mean r2 = 0.92, and was represented in 323 of our 500 bootstrapped samples. The worst-performing subset has 5 items, mean r2 = 0.81, and was represented in only 1 bootstrapped sample. Conclusions: Using less than half of the questions in the QOD-NS, excellent correlations with both total and domain-specific scores are achieved. A brief version of the QOD-NS may prove useful in future clinical and research settings.
AB - Background: The Questionnaire of Olfactory Disorders‒Negative Statements (QOD-NS) is a valuable instrument in the measurement of olfactory-specific quality of life (QOL). In the clinical setting, patients can be overwhelmed with the time required to complete questionnaires. Our objective was to develop a brief version of the QOD-NS to streamline clinical care and research. Methods: QOD-NS scores from 221 subjects were used to determine which subset of the 17 QOD-NS questions best correlated with total and subdomain QOD-NS scores. An initial pool of 11 questions was made by removing items with ρ < 0.80 to their respective subdomain scores. Next, 500 bootstrapped samples were taken. On each sampe, an all-subsets regression was performed with total QOD-NS scores and QOD-NS subdomain scores as the outcomes. From this, our “top” and “bottom” 10 subsets were identified based on mean r2 value, representation in bootstrap analysis, and number of items. Results: All of our top subsets had excellent correlation with total and subdomain QOD-NS scores (mean r2 > 0.90). Our top choice has 7 total questions, is representative of all subdomains, has a mean r2 = 0.92, and was represented in 323 of our 500 bootstrapped samples. The worst-performing subset has 5 items, mean r2 = 0.81, and was represented in only 1 bootstrapped sample. Conclusions: Using less than half of the questions in the QOD-NS, excellent correlations with both total and domain-specific scores are achieved. A brief version of the QOD-NS may prove useful in future clinical and research settings.
KW - olfaction
KW - quality of life
KW - questionnaire of olfactory disorders
KW - sinusitis
KW - smell
UR - http://www.scopus.com/inward/record.url?scp=85070924070&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85070924070&partnerID=8YFLogxK
U2 - 10.1002/alr.22392
DO - 10.1002/alr.22392
M3 - Article
AN - SCOPUS:85070924070
JO - International Forum of Allergy and Rhinology
JF - International Forum of Allergy and Rhinology
SN - 2042-6976
ER -