A brief primer on microRNAs and their roles in angiogenesis

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Development of the vasculature is a complex, dynamic process orchestrated by a balance of pro and anti-angiogenic signaling pathways. The same signaling pathways are mis-regulated and exploited during pathological angiogenesis in cancer, inflammation and cardiovascular diseases and contribute to disease progression. In the last decade, small non-coding RNA molecules termed microRNAs (miRs) have emerged as key regulators of several cellular processes including angiogenesis. It is becoming clear that miRs function in complex networks and regulate gene expression both at the mRNA and protein levels thereby altering cellular signaling responses to specific stimuli. In the vasculature, miRs can function either in a pro-angiogenic manner and potentiate angiogenesis or act as anti-angiogenic miRs by enhancing cell death and decreasing endothelial proliferation. This review aims to provide an update on how microRNAs regulate gene expression and illustrate miR function in the vasculature with a discussion of potential applications of miRs as anti-angiogenic therapeutics.

Original languageEnglish (US)
Article number2
JournalVascular Cell
Volume5
Issue number1
DOIs
StatePublished - 2013
Externally publishedYes

Fingerprint

MicroRNAs
Gene expression
Cell signaling
Complex networks
Cell death
RNA
Pathologic Neovascularization
Proteins
Gene Expression
Small Untranslated RNA
Molecules
Disease Progression
Cell Death
Cardiovascular Diseases
Inflammation
Messenger RNA
Neoplasms

Keywords

  • Angiogenesis
  • microRNA networks
  • miR-126
  • miR-132
  • NOTCH
  • Ocular angiogenesis
  • p120RasGAP

ASJC Scopus subject areas

  • Cell Biology
  • Computer Networks and Communications
  • Neurology
  • Developmental Neuroscience

Cite this

A brief primer on microRNAs and their roles in angiogenesis. / Anand, Sudarshan.

In: Vascular Cell, Vol. 5, No. 1, 2, 2013.

Research output: Contribution to journalArticle

@article{73d33ef48b864ecfb906f58cf8880a38,
title = "A brief primer on microRNAs and their roles in angiogenesis",
abstract = "Development of the vasculature is a complex, dynamic process orchestrated by a balance of pro and anti-angiogenic signaling pathways. The same signaling pathways are mis-regulated and exploited during pathological angiogenesis in cancer, inflammation and cardiovascular diseases and contribute to disease progression. In the last decade, small non-coding RNA molecules termed microRNAs (miRs) have emerged as key regulators of several cellular processes including angiogenesis. It is becoming clear that miRs function in complex networks and regulate gene expression both at the mRNA and protein levels thereby altering cellular signaling responses to specific stimuli. In the vasculature, miRs can function either in a pro-angiogenic manner and potentiate angiogenesis or act as anti-angiogenic miRs by enhancing cell death and decreasing endothelial proliferation. This review aims to provide an update on how microRNAs regulate gene expression and illustrate miR function in the vasculature with a discussion of potential applications of miRs as anti-angiogenic therapeutics.",
keywords = "Angiogenesis, microRNA networks, miR-126, miR-132, NOTCH, Ocular angiogenesis, p120RasGAP",
author = "Sudarshan Anand",
year = "2013",
doi = "10.1186/2045-824X-5-2",
language = "English (US)",
volume = "5",
journal = "Vascular Cell",
issn = "2045-824X",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - A brief primer on microRNAs and their roles in angiogenesis

AU - Anand, Sudarshan

PY - 2013

Y1 - 2013

N2 - Development of the vasculature is a complex, dynamic process orchestrated by a balance of pro and anti-angiogenic signaling pathways. The same signaling pathways are mis-regulated and exploited during pathological angiogenesis in cancer, inflammation and cardiovascular diseases and contribute to disease progression. In the last decade, small non-coding RNA molecules termed microRNAs (miRs) have emerged as key regulators of several cellular processes including angiogenesis. It is becoming clear that miRs function in complex networks and regulate gene expression both at the mRNA and protein levels thereby altering cellular signaling responses to specific stimuli. In the vasculature, miRs can function either in a pro-angiogenic manner and potentiate angiogenesis or act as anti-angiogenic miRs by enhancing cell death and decreasing endothelial proliferation. This review aims to provide an update on how microRNAs regulate gene expression and illustrate miR function in the vasculature with a discussion of potential applications of miRs as anti-angiogenic therapeutics.

AB - Development of the vasculature is a complex, dynamic process orchestrated by a balance of pro and anti-angiogenic signaling pathways. The same signaling pathways are mis-regulated and exploited during pathological angiogenesis in cancer, inflammation and cardiovascular diseases and contribute to disease progression. In the last decade, small non-coding RNA molecules termed microRNAs (miRs) have emerged as key regulators of several cellular processes including angiogenesis. It is becoming clear that miRs function in complex networks and regulate gene expression both at the mRNA and protein levels thereby altering cellular signaling responses to specific stimuli. In the vasculature, miRs can function either in a pro-angiogenic manner and potentiate angiogenesis or act as anti-angiogenic miRs by enhancing cell death and decreasing endothelial proliferation. This review aims to provide an update on how microRNAs regulate gene expression and illustrate miR function in the vasculature with a discussion of potential applications of miRs as anti-angiogenic therapeutics.

KW - Angiogenesis

KW - microRNA networks

KW - miR-126

KW - miR-132

KW - NOTCH

KW - Ocular angiogenesis

KW - p120RasGAP

UR - http://www.scopus.com/inward/record.url?scp=84873031440&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873031440&partnerID=8YFLogxK

U2 - 10.1186/2045-824X-5-2

DO - 10.1186/2045-824X-5-2

M3 - Article

C2 - 23324117

AN - SCOPUS:84873031440

VL - 5

JO - Vascular Cell

JF - Vascular Cell

SN - 2045-824X

IS - 1

M1 - 2

ER -