@inproceedings{2d71880248bc4cb89e0ae0a68e92fb2d,
title = "A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle",
abstract = "The difficulty in delineating brain tumor margins is a major obstacle in the path toward better outcomes for patients with brain tumors. Current imaging methods are often limited by inadequate sensitivity, specificity and spatial resolution. Here we show that a unique triplemodality magnetic resonance imaging - photoacoustic imaging - Raman imaging nanoparticle (termed here MPR nanoparticles), can accurately help delineate the margins of brain tumors in living mice both preoperatively and intraoperatively. The MPRs were detected by all three modalities with at least a picomolar sensitivity both in vitro and in living mice. Intravenous injection of MPRs into glioblastoma-bearing mice led to MPR accumulation and retention by the tumors, with no MPR accumulation in the surrounding healthy tissue, allowing for a noninvasive tumor delineation using all three modalities through the intact skull. Raman imaging allowed for guidance of intraoperative tumor resection, and a histological correlation validated that Raman imaging was accurately delineating the brain tumor margins. This new triple-modality-nanoparticle approach has promise for enabling more accurate brain tumor imaging and resection.",
author = "{De La Zerda}, Adam and Kircher, {Moritz F.} and Jokerst, {Jesse V.} and Zavaleta, {Cristina L.} and Kempen, {Paul J.} and Erik Mittra and Ken Pitter and Ruimin Huang and Carl Campos and Frezghi Habte and Robert Sinclair and Brennan, {Cameron W.} and Mellinghoff, {Ingo K.} and Holland, {Eric C.} and Gambhir, {Sanjiv S.}",
year = "2013",
doi = "10.1117/12.2001719",
language = "English (US)",
isbn = "9780819493507",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Photons Plus Ultrasound",
note = "Photons Plus Ultrasound: Imaging and Sensing 2013 ; Conference date: 03-02-2013 Through 05-02-2013",
}