A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle

Adam De La Zerda, Moritz F. Kircher, Jesse V. Jokerst, Cristina L. Zavaleta, Paul J. Kempen, Erik Mittra, Ken Pitter, Ruimin Huang, Carl Campos, Frezghi Habte, Robert Sinclair, Cameron W. Brennan, Ingo K. Mellinghoff, Eric C. Holland, Sanjiv S. Gambhir

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

The difficulty in delineating brain tumor margins is a major obstacle in the path toward better outcomes for patients with brain tumors. Current imaging methods are often limited by inadequate sensitivity, specificity and spatial resolution. Here we show that a unique triplemodality magnetic resonance imaging - photoacoustic imaging - Raman imaging nanoparticle (termed here MPR nanoparticles), can accurately help delineate the margins of brain tumors in living mice both preoperatively and intraoperatively. The MPRs were detected by all three modalities with at least a picomolar sensitivity both in vitro and in living mice. Intravenous injection of MPRs into glioblastoma-bearing mice led to MPR accumulation and retention by the tumors, with no MPR accumulation in the surrounding healthy tissue, allowing for a noninvasive tumor delineation using all three modalities through the intact skull. Raman imaging allowed for guidance of intraoperative tumor resection, and a histological correlation validated that Raman imaging was accurately delineating the brain tumor margins. This new triple-modality-nanoparticle approach has promise for enabling more accurate brain tumor imaging and resection.

Original languageEnglish (US)
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2013
DOIs
StatePublished - May 28 2013
Externally publishedYes
EventPhotons Plus Ultrasound: Imaging and Sensing 2013 - San Francisco, CA, United States
Duration: Feb 3 2013Feb 5 2013

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8581
ISSN (Print)1605-7422

Conference

ConferencePhotons Plus Ultrasound: Imaging and Sensing 2013
CountryUnited States
CitySan Francisco, CA
Period2/3/132/5/13

Fingerprint

Molecular imaging
Molecular Imaging
Photoacoustic effect
Brain Neoplasms
Nanoparticles
Magnetic resonance imaging
brain
Tumors
Brain
tumors
nanoparticles
Imaging techniques
mice
margins
Neoplasms
Glioblastoma
Bearings (structural)
Skull
Neuroimaging
Intravenous Injections

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

De La Zerda, A., Kircher, M. F., Jokerst, J. V., Zavaleta, C. L., Kempen, P. J., Mittra, E., ... Gambhir, S. S. (2013). A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle. In Photons Plus Ultrasound: Imaging and Sensing 2013 [85810G] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8581). https://doi.org/10.1117/12.2001719

A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle. / De La Zerda, Adam; Kircher, Moritz F.; Jokerst, Jesse V.; Zavaleta, Cristina L.; Kempen, Paul J.; Mittra, Erik; Pitter, Ken; Huang, Ruimin; Campos, Carl; Habte, Frezghi; Sinclair, Robert; Brennan, Cameron W.; Mellinghoff, Ingo K.; Holland, Eric C.; Gambhir, Sanjiv S.

Photons Plus Ultrasound: Imaging and Sensing 2013. 2013. 85810G (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8581).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

De La Zerda, A, Kircher, MF, Jokerst, JV, Zavaleta, CL, Kempen, PJ, Mittra, E, Pitter, K, Huang, R, Campos, C, Habte, F, Sinclair, R, Brennan, CW, Mellinghoff, IK, Holland, EC & Gambhir, SS 2013, A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle. in Photons Plus Ultrasound: Imaging and Sensing 2013., 85810G, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, San Francisco, CA, United States, 2/3/13. https://doi.org/10.1117/12.2001719
De La Zerda A, Kircher MF, Jokerst JV, Zavaleta CL, Kempen PJ, Mittra E et al. A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle. In Photons Plus Ultrasound: Imaging and Sensing 2013. 2013. 85810G. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.2001719
De La Zerda, Adam ; Kircher, Moritz F. ; Jokerst, Jesse V. ; Zavaleta, Cristina L. ; Kempen, Paul J. ; Mittra, Erik ; Pitter, Ken ; Huang, Ruimin ; Campos, Carl ; Habte, Frezghi ; Sinclair, Robert ; Brennan, Cameron W. ; Mellinghoff, Ingo K. ; Holland, Eric C. ; Gambhir, Sanjiv S. / A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle. Photons Plus Ultrasound: Imaging and Sensing 2013. 2013. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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