A blood-based nutritional risk index explains cognitive enhancement and decline in the multidomain Alzheimer prevention trial

MAPT/DSA Study Group

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Introduction: Multinutrient approaches may produce more robust effects on brain health through interactive qualities. We hypothesized that a blood-based nutritional risk index (NRI) including three biomarkers of diet quality can explain cognitive trajectories in the multidomain Alzheimer prevention trial (MAPT) over 3-years. Methods: The NRI included erythrocyte n-3 polyunsaturated fatty acids (n-3 PUFA 22:6n-3 and 20:5n-3), serum 25-hydroxyvitamin D, and plasma homocysteine. The NRI scores reflect the number of nutritional risk factors (0–3). The primary outcome in MAPT was a cognitive composite Z score within each participant that was fit with linear mixed-effects models. Results: Eighty percent had at lease one nutritional risk factor for cognitive decline (NRI ≥1: 573 of 712). Participants presenting without nutritional risk factors (NRI=0) exhibited cognitive enhancement (β = 0.03 standard units [SU]/y), whereas each NRI point increase corresponded to an incremental acceleration in rates of cognitive decline (NRI-1: β = −0.04 SU/y, P = .03; NRI-2: β = −0.08 SU/y, P < .0001; and NRI-3: β = −0.11 SU/y, P = .0008). Discussion: Identifying and addressing these well-established nutritional risk factors may reduce age-related cognitive decline in older adults; an observation that warrants further study.

Original languageEnglish (US)
Pages (from-to)953-963
Number of pages11
JournalAlzheimer's and Dementia: Translational Research and Clinical Interventions
Volume5
DOIs
StatePublished - 2019

Keywords

  • Aging
  • Biomarkers of diet quality
  • Cognitive decline
  • DHA
  • EPA
  • Elderly
  • Homocysteine
  • Metabolomics
  • Nutrient biomarkers
  • Omega-3 fatty acids
  • Vitamin D

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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