A blood-based nutritional risk index explains cognitive enhancement and decline in the multidomain Alzheimer prevention trial

MAPT/DSA Study Group

doi:10.1016/j.trci.2019.11.004

A blood-based nutritional risk index explains cognitive enhancement and decline in the multidomain Alzheimer prevention trial

MAPT/DSA Study Group

Neurology

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Introduction: Multinutrient approaches may produce more robust effects on brain health through interactive qualities. We hypothesized that a blood-based nutritional risk index (NRI) including three biomarkers of diet quality can explain cognitive trajectories in the multidomain Alzheimer prevention trial (MAPT) over 3-years. Methods: The NRI included erythrocyte n-3 polyunsaturated fatty acids (n-3 PUFA 22:6n-3 and 20:5n-3), serum 25-hydroxyvitamin D, and plasma homocysteine. The NRI scores reflect the number of nutritional risk factors (0–3). The primary outcome in MAPT was a cognitive composite Z score within each participant that was fit with linear mixed-effects models. Results: Eighty percent had at lease one nutritional risk factor for cognitive decline (NRI ≥1: 573 of 712). Participants presenting without nutritional risk factors (NRI=0) exhibited cognitive enhancement (β = 0.03 standard units [SU]/y), whereas each NRI point increase corresponded to an incremental acceleration in rates of cognitive decline (NRI-1: β = −0.04 SU/y, P = .03; NRI-2: β = −0.08 SU/y, P < .0001; and NRI-3: β = −0.11 SU/y, P = .0008). Discussion: Identifying and addressing these well-established nutritional risk factors may reduce age-related cognitive decline in older adults; an observation that warrants further study.

Original language	English (US)
Pages (from-to)	953-963
Number of pages	11
Journal	Alzheimer's and Dementia: Translational Research and Clinical Interventions
Volume	5
DOIs	https://doi.org/10.1016/j.trci.2019.11.004
State	Published - 2019

Keywords

Aging
Biomarkers of diet quality
Cognitive decline
DHA
EPA
Elderly
Homocysteine
Metabolomics
Nutrient biomarkers
Omega-3 fatty acids
Vitamin D

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

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10.1016/j.trci.2019.11.004

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@article{0014565734e14a32aa273a60b13e3a55,

title = "A blood-based nutritional risk index explains cognitive enhancement and decline in the multidomain Alzheimer prevention trial",

abstract = "Introduction: Multinutrient approaches may produce more robust effects on brain health through interactive qualities. We hypothesized that a blood-based nutritional risk index (NRI) including three biomarkers of diet quality can explain cognitive trajectories in the multidomain Alzheimer prevention trial (MAPT) over 3-years. Methods: The NRI included erythrocyte n-3 polyunsaturated fatty acids (n-3 PUFA 22:6n-3 and 20:5n-3), serum 25-hydroxyvitamin D, and plasma homocysteine. The NRI scores reflect the number of nutritional risk factors (0–3). The primary outcome in MAPT was a cognitive composite Z score within each participant that was fit with linear mixed-effects models. Results: Eighty percent had at lease one nutritional risk factor for cognitive decline (NRI ≥1: 573 of 712). Participants presenting without nutritional risk factors (NRI=0) exhibited cognitive enhancement (β = 0.03 standard units [SU]/y), whereas each NRI point increase corresponded to an incremental acceleration in rates of cognitive decline (NRI-1: β = −0.04 SU/y, P = .03; NRI-2: β = −0.08 SU/y, P < .0001; and NRI-3: β = −0.11 SU/y, P = .0008). Discussion: Identifying and addressing these well-established nutritional risk factors may reduce age-related cognitive decline in older adults; an observation that warrants further study.",

keywords = "Aging, Biomarkers of diet quality, Cognitive decline, DHA, EPA, Elderly, Homocysteine, Metabolomics, Nutrient biomarkers, Omega-3 fatty acids, Vitamin D",

author = "{MAPT/DSA Study Group} and Bowman, {Gene L.} and Dodge, {Hiroko H.} and Sophie Guyonnet and Nina Zhou and Juliana Donohue and Aline Bichsel and Jeroen Schmitt and Claudie Hooper and Tamas Bartfai and Sandrine Andrieu and Bruno Vellas and Isabelle Carri{\'e} and Laur{\'e}ane Brigitte and Catherine Faisant and Fran{\c c}oise Lala and Julien Delrieu and H{\'e}l{\`e}ne Villars and Emeline Combrouze and Carole Badufle and Audrey Zueras and Christelle Cantet and Christophe Morin and {Van Kan}, {Gabor Abellan} and Charlotte Dupuy and Yves Rolland and C{\'e}line Caillaud and Ousset, {Pierre Jean}",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

doi = "10.1016/j.trci.2019.11.004",

language = "English (US)",

volume = "5",

pages = "953--963",

journal = "Alzheimer's and Dementia: Translational Research and Clinical Interventions",

issn = "2352-8737",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - A blood-based nutritional risk index explains cognitive enhancement and decline in the multidomain Alzheimer prevention trial

AU - MAPT/DSA Study Group

AU - Bowman, Gene L.

AU - Dodge, Hiroko H.

AU - Guyonnet, Sophie

AU - Zhou, Nina

AU - Donohue, Juliana

AU - Bichsel, Aline

AU - Schmitt, Jeroen

AU - Hooper, Claudie

AU - Bartfai, Tamas

AU - Andrieu, Sandrine

AU - Vellas, Bruno

AU - Carrié, Isabelle

AU - Brigitte, Lauréane

AU - Faisant, Catherine

AU - Lala, Françoise

AU - Delrieu, Julien

AU - Villars, Hélène

AU - Combrouze, Emeline

AU - Badufle, Carole

AU - Zueras, Audrey

AU - Cantet, Christelle

AU - Morin, Christophe

AU - Van Kan, Gabor Abellan

AU - Dupuy, Charlotte

AU - Rolland, Yves

AU - Caillaud, Céline

AU - Ousset, Pierre Jean

PY - 2019

Y1 - 2019

N2 - Introduction: Multinutrient approaches may produce more robust effects on brain health through interactive qualities. We hypothesized that a blood-based nutritional risk index (NRI) including three biomarkers of diet quality can explain cognitive trajectories in the multidomain Alzheimer prevention trial (MAPT) over 3-years. Methods: The NRI included erythrocyte n-3 polyunsaturated fatty acids (n-3 PUFA 22:6n-3 and 20:5n-3), serum 25-hydroxyvitamin D, and plasma homocysteine. The NRI scores reflect the number of nutritional risk factors (0–3). The primary outcome in MAPT was a cognitive composite Z score within each participant that was fit with linear mixed-effects models. Results: Eighty percent had at lease one nutritional risk factor for cognitive decline (NRI ≥1: 573 of 712). Participants presenting without nutritional risk factors (NRI=0) exhibited cognitive enhancement (β = 0.03 standard units [SU]/y), whereas each NRI point increase corresponded to an incremental acceleration in rates of cognitive decline (NRI-1: β = −0.04 SU/y, P = .03; NRI-2: β = −0.08 SU/y, P < .0001; and NRI-3: β = −0.11 SU/y, P = .0008). Discussion: Identifying and addressing these well-established nutritional risk factors may reduce age-related cognitive decline in older adults; an observation that warrants further study.

AB - Introduction: Multinutrient approaches may produce more robust effects on brain health through interactive qualities. We hypothesized that a blood-based nutritional risk index (NRI) including three biomarkers of diet quality can explain cognitive trajectories in the multidomain Alzheimer prevention trial (MAPT) over 3-years. Methods: The NRI included erythrocyte n-3 polyunsaturated fatty acids (n-3 PUFA 22:6n-3 and 20:5n-3), serum 25-hydroxyvitamin D, and plasma homocysteine. The NRI scores reflect the number of nutritional risk factors (0–3). The primary outcome in MAPT was a cognitive composite Z score within each participant that was fit with linear mixed-effects models. Results: Eighty percent had at lease one nutritional risk factor for cognitive decline (NRI ≥1: 573 of 712). Participants presenting without nutritional risk factors (NRI=0) exhibited cognitive enhancement (β = 0.03 standard units [SU]/y), whereas each NRI point increase corresponded to an incremental acceleration in rates of cognitive decline (NRI-1: β = −0.04 SU/y, P = .03; NRI-2: β = −0.08 SU/y, P < .0001; and NRI-3: β = −0.11 SU/y, P = .0008). Discussion: Identifying and addressing these well-established nutritional risk factors may reduce age-related cognitive decline in older adults; an observation that warrants further study.

KW - Aging

KW - Biomarkers of diet quality

KW - Cognitive decline

KW - DHA

KW - EPA

KW - Elderly

KW - Homocysteine

KW - Metabolomics

KW - Nutrient biomarkers

KW - Omega-3 fatty acids

KW - Vitamin D

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UR - http://www.scopus.com/inward/citedby.url?scp=85077017706&partnerID=8YFLogxK

U2 - 10.1016/j.trci.2019.11.004

DO - 10.1016/j.trci.2019.11.004

M3 - Article

AN - SCOPUS:85077017706

SN - 2352-8737

VL - 5

SP - 953

EP - 963

JO - Alzheimer's and Dementia: Translational Research and Clinical Interventions

JF - Alzheimer's and Dementia: Translational Research and Clinical Interventions

ER -

A blood-based nutritional risk index explains cognitive enhancement and decline in the multidomain Alzheimer prevention trial

Abstract

Keywords

ASJC Scopus subject areas

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