A bacterial source for mollusk pyrone polyketides

Zhenjian Lin, Joshua P. Torres, Mary Anne Ammon, Lenny Marett, Russell W. Teichert, Christopher A. Reilly, Jason C. Kwan, Ronald W. Hughen, Malem Flores, Ma Diarey Tianero, Olivier Peraud, James E. Cox, Alan R. Light, Aaron Joseph L Villaraza, Margo Haygood, Gisela P. Concepcion, Baldomero M. Olivera, Eric W. Schmidt

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

In the oceans, secondary metabolites often protect otherwise poorly defended invertebrates, such as shell-less mollusks, from predation. The origins of these metabolites are largely unknown, but many of them are thought to be made by symbiotic bacteria. In contrast, mollusks with thick shells and toxic venoms are thought to lack these secondary metabolites because of reduced defensive needs. Here, we show that heavily defended cone snails also occasionally contain abundant secondary metabolites, γ-pyrones known as nocapyrones, which are synthesized by symbiotic bacteria. The bacteria, Nocardiopsis alba CR167, are related to widespread actinomycetes that we propose to be casual symbionts of invertebrates on land and in the sea. The natural roles of nocapyrones are unknown, but they are active in neurological assays, revealing that mollusks with external shells are an overlooked source of secondary metabolite diversity.

Original languageEnglish (US)
Pages (from-to)73-81
Number of pages9
JournalChemistry and Biology
Volume20
Issue number1
DOIs
StatePublished - Jan 24 2013

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Pyrones
Polyketides
Mollusca
Metabolites
Invertebrates
Bacteria
Oceans and Seas
Actinobacteria
Poisons
Snails
Venoms
Cones
Assays

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Molecular Biology
  • Clinical Biochemistry
  • Molecular Medicine
  • Pharmacology

Cite this

Lin, Z., Torres, J. P., Ammon, M. A., Marett, L., Teichert, R. W., Reilly, C. A., ... Schmidt, E. W. (2013). A bacterial source for mollusk pyrone polyketides. Chemistry and Biology, 20(1), 73-81. https://doi.org/10.1016/j.chembiol.2012.10.019

A bacterial source for mollusk pyrone polyketides. / Lin, Zhenjian; Torres, Joshua P.; Ammon, Mary Anne; Marett, Lenny; Teichert, Russell W.; Reilly, Christopher A.; Kwan, Jason C.; Hughen, Ronald W.; Flores, Malem; Tianero, Ma Diarey; Peraud, Olivier; Cox, James E.; Light, Alan R.; Villaraza, Aaron Joseph L; Haygood, Margo; Concepcion, Gisela P.; Olivera, Baldomero M.; Schmidt, Eric W.

In: Chemistry and Biology, Vol. 20, No. 1, 24.01.2013, p. 73-81.

Research output: Contribution to journalArticle

Lin, Z, Torres, JP, Ammon, MA, Marett, L, Teichert, RW, Reilly, CA, Kwan, JC, Hughen, RW, Flores, M, Tianero, MD, Peraud, O, Cox, JE, Light, AR, Villaraza, AJL, Haygood, M, Concepcion, GP, Olivera, BM & Schmidt, EW 2013, 'A bacterial source for mollusk pyrone polyketides', Chemistry and Biology, vol. 20, no. 1, pp. 73-81. https://doi.org/10.1016/j.chembiol.2012.10.019
Lin Z, Torres JP, Ammon MA, Marett L, Teichert RW, Reilly CA et al. A bacterial source for mollusk pyrone polyketides. Chemistry and Biology. 2013 Jan 24;20(1):73-81. https://doi.org/10.1016/j.chembiol.2012.10.019
Lin, Zhenjian ; Torres, Joshua P. ; Ammon, Mary Anne ; Marett, Lenny ; Teichert, Russell W. ; Reilly, Christopher A. ; Kwan, Jason C. ; Hughen, Ronald W. ; Flores, Malem ; Tianero, Ma Diarey ; Peraud, Olivier ; Cox, James E. ; Light, Alan R. ; Villaraza, Aaron Joseph L ; Haygood, Margo ; Concepcion, Gisela P. ; Olivera, Baldomero M. ; Schmidt, Eric W. / A bacterial source for mollusk pyrone polyketides. In: Chemistry and Biology. 2013 ; Vol. 20, No. 1. pp. 73-81.
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