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  • Halina Offner
2020

A Novel Partial MHC Class II Construct, DRmQ, Inhibits Central and Peripheral Inflammatory Responses to Promote Neuroprotection in Experimental Stroke

Lee, J. Y., Castelli, V., Bonsack, B., Coats, A. B., Navarro-Torres, L., Garcia-Sanchez, J., Kingsbury, C., Nguyen, H., Vandenbark, A. A., Meza-Romero, R., Offner, H. & Borlongan, C. V., Aug 1 2020, In : Translational Stroke Research. 11, 4, p. 831-836 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Spleen participation in partial MHC class II construct neuroprotection in stroke

Brown, J., Kingsbury, C., Lee, J. Y., Vandenbark, A. A., Meza-Romero, R., Offner, H. & Borlongan, C. V., Jul 1 2020, In : CNS Neuroscience and Therapeutics. 26, 7, p. 663-669 7 p.

Research output: Contribution to journalReview article

Open Access

Surviving the storm: Dealing with COVID-19

Vandenbark, A. A., Meza-Romero, R. & Offner, H., Aug 2020, In : Cellular Immunology. 354, 104153.

Research output: Contribution to journalLetter

2019

A novel neurotherapeutic for multiple sclerosis, ischemic injury, methamphetamine addiction, and traumatic brain injury

Vandenbark, A. A., Meza-Romero, R., Benedek, G. & Offner, H., Jan 23 2019, In : Journal of Neuroinflammation. 16, 1, 14.

Research output: Contribution to journalReview article

4 Scopus citations

Estrogen-induced compensatory mechanisms protect IL-10-deficient mice from developing EAE

Seifert, H. A., Gerstner, G., Kent, G., Vandenbark, A. A. & Offner, H., Oct 29 2019, In : Journal of Neuroinflammation. 16, 1, 195.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Increased CD74 binding and EAE treatment efficacy of a modified DRα1 molecular construct

Meza-Romero, R., Benedek, G., Gerstner, G., Kent, G., Nguyen, H., Offner, H. & Vandenbark, A. A., Feb 1 2019, In : Metabolic brain disease. 34, 1, p. 153-164 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Sex differences in the therapeutic effects of anti-PDL2 neutralizing antibody on stroke

Seifert, H. A., Zhu, W., Vandenbark, A. A., Alkayed, N. J. & Offner, H., Dec 1 2019, In : Metabolic brain disease. 34, 6, p. 1705-1712 8 p.

Research output: Contribution to journalArticle

2018

Antibiotics protect against EAE by increasing regulatory and anti-inflammatory cells

Seifert, H. A., Benedek, G., Nguyen, H., Gerstner, G., Zhang, Y., Kent, G., Vandenbark, A. A., Bernhagen, J. & Offner, H., Oct 1 2018, In : Metabolic brain disease. 33, 5, p. 1599-1607 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Regulatory B cells in experimental stroke

Seifert, H. A., Vandenbark, A. & Offner, H., Jan 1 2018, (Accepted/In press) In : Immunology.

Research output: Contribution to journalArticle

8 Scopus citations

The splenic response to stroke: From rodents to stroke subjects

Seifert, H. A. & Offner, H., Jul 3 2018, In : Journal of Neuroinflammation. 15, 1, 195.

Research output: Contribution to journalReview article

15 Scopus citations

Uncovering the Rosetta Stone: Report from the First Annual Conference on Key Elements in Translating Stroke Therapeutics from Pre-Clinical to Clinical

Bix, G. J., Fraser, J. F., Mack, W. J., Carmichael, S. T., Perez-Pinzon, M., Offner, H., Sansing, L., Bosetti, F., Ayata, C. & Pennypacker, K. R., Apr 10 2018, (Accepted/In press) In : Translational Stroke Research. p. 1-9 9 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

DRα1-MOG-35-55 Reduces Permanent Ischemic Brain Injury

Wang, J., Ye, Q., Xu, J., Benedek, G., Zhang, H., Yang, Y., Liu, H., Meza-Romero, R., Vandenbark, A. A., Offner, H. & Gao, Y., Jun 1 2017, In : Translational Stroke Research. 8, 3

Research output: Contribution to journalArticle

15 Scopus citations

DRα1-MOG-35-55 treatment reduces lesion volumes and improves neurological deficits after traumatic brain injury

Yang, L., Liu, Z., Ren, H., Zhang, L., Gao, S., Ren, L., Chai, Z., Meza-Romero, R., Benedek, G., Vandenbark, A. A., Offner, H. & Li, M., Oct 1 2017, In : Metabolic brain disease. 32, 5, p. 1395-1402 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Estrogen protection against EAE modulates the microbiota and mucosal-associated regulatory cells

Benedek, G., Zhang, J., Nguyen, H., Kent, G., Seifert, H. A., Davin, S., Stauffer, P., Vandenbark, A. A., Karstens, L., Asquith, M. & Offner, H., Sep 15 2017, In : Journal of Neuroimmunology. 310, p. 51-59 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Estrogen protects both sexes against EAE by promoting common regulatory cell subtypes independent of endogenous estrogen

Seifert, H. A., Benedek, G., Nguyen, H., Kent, G., Vandenbark, A. & Offner, H., Jul 8 2017, (Accepted/In press) In : Metabolic Brain Disease. p. 1-8 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

MIF and D-DT are potential disease severity modifiers in male MS subjects

Benedek, G., Meza-Romero, R., Jordan, K., Zhang, Y., Nguyen, H., Kent, G., Li, J., Siu, E., Frazer, J., Piecychna, M., Du, X., Sreih, A., Leng, L., Wiedrick, J., Caillier, S. J., Offner, H., Oksenberg, J. R., Yadav, V., Bourdette, D., Bucala, R. & 1 others, Vandenbark, A. A., Oct 3 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 40, p. E8421-E8429

Research output: Contribution to journalArticle

37 Scopus citations

Novel feedback loop between M2 macrophages/microglia and regulatory B cells in estrogen-protected EAE mice

Benedek, G., Zhang, J., Nguyen, H., Kent, G., Seifert, H., Vandenbark, A. A. & Offner, H., Apr 15 2017, In : Journal of Neuroimmunology. 305, p. 59-67 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Sex-dependent treatment of chronic EAE with partial MHC class II constructs

Benedek, G., Chaudhary, P., Meza-Romero, R., Calkins, E., Kent, G., Offner, H., Bourdette, D. & Vandenbark, A. A., May 6 2017, In : Journal of Neuroinflammation. 14, 1, 100.

Research output: Contribution to journalArticle

7 Scopus citations

Sex differences in regulatory cells in experimental stroke

Seifert, H. A., Benedek, G., Liang, J., Nguyen, H., Kent, G., Vandenbark, A., Saugstad, J. & Offner, H., May 23 2017, (Accepted/In press) In : Cellular Immunology.

Research output: Contribution to journalArticle

9 Scopus citations

Sex differences in the immune response to experimental stroke: Implications for translational research

Dotson, A. L. & Offner, H., Jan 1 2017, In : Journal of Neuroscience Research. 95, 1-2, p. 437-446 10 p.

Research output: Contribution to journalReview article

12 Scopus citations

Stroke and other cerebrovascular diseases

Offner, H., Ihara, M., Schäbitz, W. R. & Wong, P. T. H., 2017, (Accepted/In press) In : Neurochemistry International.

Research output: Contribution to journalArticle

1 Scopus citations
2016

Estrogen induces multiple regulatory B cell subtypes and promotes M2 microglia and neuroprotection during experimental autoimmune encephalomyelitis

Benedek, G., Zhang, J., Bodhankar, S., Nguyen, H., Kent, G., Jordan, K., Manning, D., Vandenbark, A. A. & Offner, H., Apr 15 2016, In : Journal of Neuroimmunology. 293, p. 45-53 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Loss of PPARα perpetuates sex differences in stroke reflected by peripheral immune mechanisms

Dotson, A. L., Wang, J., Liang, J., Nguyen, H., Manning, D., Saugstad, J. A. & Offner, H., Jun 1 2016, In : Metabolic brain disease. 31, 3, p. 683-692 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Partial MHC class II constructs as novel immunomodulatory therapy for stroke

Benedek, G., Vandenbark, A., Alkayed, N. & Offner, H., Sep 1 2016, (Accepted/In press) In : Neurochemistry International.

Research output: Contribution to journalArticle

8 Scopus citations

Partial MHC Constructs Treat Thromboembolic Ischemic Stroke Characterized by Early Immune Expansion

Dotson, A. L., Chen, Y., Zhu, W., Libal, N., Alkayed, N. J. & Offner, H., Feb 1 2016, In : Translational Stroke Research. 7, 1, p. 70-78 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Sex differences and the role of PPAR alpha in experimental stroke

Dotson, A. L., Wang, J., Chen, Y., Manning, D., Nguyen, H., Saugstad, J. A. & Offner, H., Jun 1 2016, In : Metabolic brain disease. 31, 3, p. 539-547 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Upregulation of CD74 and its potential association with disease severity in subjects with ischemic stroke

Yang, L., Kong, Y., Ren, H., Li, M., Wei, C. J., Shi, E., Jin, W. N., Hao, J., Vandenbark, A. & Offner, H., Sep 13 2016, (Accepted/In press) In : Neurochemistry International.

Research output: Contribution to journalArticle

6 Scopus citations
2015

A novel mouse model of thromboembolic stroke

Chen, Y., Zhu, W., Zhang, W., Libal, N., Murphy, S. J., Offner, H. & Alkayed, N. J., Dec 30 2015, In : Journal of Neuroscience Methods. 256, p. 203-211 9 p.

Research output: Contribution to journalReview article

15 Scopus citations

Functional Role of Regulatory Lymphocytes in Stroke

Liesz, A., Hu, X., Kleinschnitz, C. & Offner, H., May 20 2015, In : Stroke. 46, 5, p. 1422-1430 9 p.

Research output: Contribution to journalReview article

57 Scopus citations
15 Scopus citations

IL-10 producing B cells partially restore E2-mediated protection against EAE in PD-L1 deficient mice

Zhang, J., Benedek, G., Bodhankar, S., Lapato, A., Vandenbark, A. A. & Offner, H., Jan 1 2015, In : Journal of Neuroimmunology. 285, p. 129-136 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

PD-L1 monoclonal antibody treats ischemic stroke by controlling central nervous system inflammation

Bodhankar, S., Chen, Y., Lapato, A., Dotson, A. L., Wang, J., Vandenbark, A. A., Saugstad, J. A. & Offner, H., 2015, In : Stroke. 46, 10, p. 2926-2934 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Recombinant T-cell receptor ligand RTL1000 limits inflammation and decreases infarct size after experimental ischemic stroke in middle-aged mice

Zhu, W., Dotson, A. L., Libal, N. L., Lapato, A. S., Bodhankar, S., Offner, H. & Alkayed, N. J., Mar 2 2015, In : Neuroscience. 288, p. 112-119 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Regulatory CD8+CD122+ T-cells predominate in CNS after treatment of experimental stroke in male mice with IL-10-secreting B-cells

Bodhankar, S., Chen, Y., Lapato, A., Vandenbark, A. A., Murphy, S. J., Saugstad, J. A. & Offner, H., Aug 1 2015, In : Metabolic brain disease. 30, 4, p. 911-924 14 p., A003.

Research output: Contribution to journalArticle

21 Scopus citations

Role for microglia in sex differences after ischemic stroke: importance of M2

Bodhankar, S., Lapato, A., Chen, Y., Vandenbark, A. A., Saugstad, J. A. & Offner, H., Dec 1 2015, In : Metabolic brain disease. 30, 6, p. 1515-1529 15 p.

Research output: Contribution to journalArticle

30 Scopus citations

Splenectomy reduces infarct volume and neuroinflammation in male but not female mice in experimental stroke

Dotson, A. L., Wang, J., Saugstad, J., Murphy, S. J. & Offner, H., Jan 15 2015, In : Journal of Neuroimmunology. 278, p. 289-298 10 p.

Research output: Contribution to journalArticle

41 Scopus citations

The role of the spleen in ischemic stroke

Pennypacker, K. R. & Offner, H., Feb 2 2015, In : Journal of Cerebral Blood Flow and Metabolism. 35, 2, p. 186-187 2 p.

Research output: Contribution to journalReview article

29 Scopus citations

Treatment with IL-10 producing B cells in combination with E2 ameliorates EAE severity and decreases CNS inflammation in B cell-deficient mice

Zhang, J., Lapato, A., Bodhankar, S., Vandenbark, A. A. & Offner, H., Oct 10 2015, In : Metabolic brain disease. 30, 5, p. 1117-1127 11 p.

Research output: Contribution to journalArticle

24 Scopus citations
2014

A novel HLA-DRα1-MOG-35-55 construct treats experimental stroke

Benedek, G., Zhu, W., Libal, N., Casper, A., Yu, X., Meza-Romero, R., Vandenbark, A. A., Alkayed, N. J. & Offner, H., Mar 2014, In : Metabolic brain disease. 29, 1, p. 37-45 9 p.

Research output: Contribution to journalArticle

20 Scopus citations
11 Scopus citations

Erratum to: A novel HLA-DRα1-MOG-35-55 construct treats experimental stroke (Metabolic Brain Disease (2014) 29, (37-45) DOI: 10.1007/s11011-013-9440- 0)

Benedek, G., Zhu, W., Libal, N., Casper, A., Yu, X., Meza-Romero, R., Vandenbark, A. A., Alkayed, N. J. & Offner, H., Jan 1 2014, In : Metabolic brain disease. 29, 3, 1 p.

Research output: Contribution to journalComment/debate

HLA-DRα1 constructs block CD74 expression and MIF effects in experimental autoimmune encephalomyelitis

Meza-Romero, R., Benedek, G., Yu, X., Mooney, J. L., Dahan, R., Duvshani, N., Bucala, R., Offner, H., Reiter, Y., Burrows, G. G. & Vandenbark, A. A., May 1 2014, In : Journal of Immunology. 192, 9, p. 4164-4173 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Modeling immunity and inflammation in stroke don't be afraid of mice?

Offner, H., Sep 1 2014, In : Stroke. 45, 9, p. e181-e182

Research output: Contribution to journalArticle

2 Scopus citations

Novel Humanized Recombinant T Cell Receptor Ligands Protect the Female Brain After Experimental Stroke

Pan, J., Palmateer, J., Schallert, T., Hart, M., Pandya, A., Vandenbark, A. A., Offner, H. & Hurn, P. D., Oct 2014, In : Translational Stroke Research. 5, 5, p. 577-585 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Preclinical Evaluation of Recombinant T Cell Receptor Ligand RTL1000 as a Therapeutic Agent in Ischemic Stroke

Zhu, W., Casper, A., Libal, N. L., Murphy, S. J., Bodhankar, S., Offner, H. & Alkayed, N. J., Jan 1 2014, In : Translational Stroke Research. 6, 1, p. 60-68 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Recombinant T Cell Receptor Ligand Treatment Improves Neurological Outcome in the Presence of Tissue Plasminogen Activator in Experimental Ischemic Stroke

Zhu, W., Libal, N. L., Casper, A., Bodhankar, S., Offner, H. & Alkayed, N. J., Oct 2014, In : Translational Stroke Research. 5, 5, p. 612-617 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

Systemic immune responses after experimental stroke

Offner, H. & Hurn, P. D., Jan 1 2014, Immunological Mechanisms and Therapies in Brain Injuries and Stroke. Springer New York, p. 153-176 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Thrombin mutant W215A/E217A treatment improves neurological outcome and attenuates central nervous system damage in experimental autoimmune encephalomyelitis

Verbout, N. G., Yu, X., Healy, L. D., Phillips, K. G., Tucker, E. I., Gruber, A., McCarty, O. J. T. & Offner, H., Jan 1 2014, In : Metabolic brain disease. 30, 1, p. 57-65 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
42 Scopus citations
2013

A novel regulatory pathway for autoimmune disease: Binding of partial MHC class II constructs to monocytes reduces CD74 expression and induces both specific and bystander T-cell tolerance

Vandenbark, A. A., Meza-Romero, R., Benedek, G., Andrew, S., Huan, J., Chou, Y. K., Buenafe, A. C., Dahan, R., Reiter, Y., Mooney, J. L., Offner, H. & Burrows, G. G., Feb 1 2013, In : Journal of Autoimmunity. 40, 1, p. 96-110 15 p.

Research output: Contribution to journalArticle

28 Scopus citations