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  • Edward Neuwelt
2020

Diagnostic impact of preoperative corticosteroids in primary central nervous system lymphoma

Bullis, C. L., Maldonado-Perez, A., Bowden, S. G., Yaghi, N., Munger, D., Wood, M. D., Barajas, R. F., Ambady, P., Neuwelt, E. A. & Han, S. J., Feb 2020, In : Journal of Clinical Neuroscience. 72, p. 287-291 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Impact of maintenance rituximab on duration of response in primary central nervous system lymphoma

Ambady, P., Fu, R., Szidonya, L., Peereboom, D. M., Doolittle, N. & Neuwelt, E. A., Jan 1 2020, (Accepted/In press) In : Journal of Neuro-Oncology.

Research output: Contribution to journalReview article

1 Scopus citations
2019

Combined iron oxide nanoparticle ferumoxytol and gadolinium contrast enhanced MRI define glioblastoma pseudoprogression

Barajas, R. F., Hamilton, B. E., Schwartz, D., Mcconnell, H. L., Pettersson, D. R., Horvath, A., Szidonya, L., Varallyay, C. G., Firkins, J., Jaboin, J. J., Kubicky, C. D., Raslan, A. M., Dogan, A., Cetas, J. S., Ciporen, J., Han, S. J., Ambady, P., Muldoon, L. L., Woltjer, R., Rooney, W. D. & 1 others, Neuwelt, E. A., Mar 18 2019, In : Neuro-Oncology. 21, 4, p. 517-526 10 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Toll-like Receptor 4 Signaling and Downstream Neutrophilic Inflammation Mediate Endotoxemia-Enhanced Blood-Labyrinth Barrier Trafficking

Urdang, Z. D., Bills, J. L., Cahana, D. Y., Muldoon, L. L. & Neuwelt, E. A., Jan 1 2019, (Accepted/In press) In : Otology and Neurotology.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Blood-Brain Barrier Disruption Chemotherapy

McGregor, J. M., Bell, S. D., Doolittle, N., Murillo, T. P. & Neuwelt, E., Apr 24 2018, Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy: Second Edition. Elsevier Inc., p. 145-153 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Cerebral blood volume mapping with ferumoxytol in dynamic susceptibility contrast perfusion MRI: Comparison to standard of care

Varallyay, C. G., Nesbit, E., Horvath, A., Varallyay, P., Fu, R. R., Gahramanov, S., Muldoon, L., Li, X., Rooney, W. & Neuwelt, E., Jan 1 2018, (Accepted/In press) In : Journal of Magnetic Resonance Imaging.

Research output: Contribution to journalArticle

2 Scopus citations

Combination immunotherapy as a non-chemotherapy alternative for refractory or recurrent CNS lymphoma

Ambady, P., Szidonya, L., Firkins, J., James, J., Johansson, K., White, T., Jezierski, C., Doolittle, N. & Neuwelt, E., Jan 1 2018, (Accepted/In press) In : Leukemia and Lymphoma.

Research output: Contribution to journalArticle

2 Scopus citations

Neurovascular unit: Basic and clinical imaging with emphasis on advantages of ferumoxytol

Netto, J. P., Iliff, J., Stanimirovic, D., Krohn, K. A., Hamilton, B., Varallyay, C., Gahramanov, S., Daldrup-Link, H., D'Esterre, C., Zlokovic, B., Sair, H., Lee, Y., Taheri, S., Jain, R., Panigrahy, A., Reich, D. S., Drewes, L. R., Castillo, M. & Neuwelt, E., Jan 1 2018, In : Neurosurgery. 82, 6, p. 770-780 11 p.

Research output: Contribution to journalReview article

Open Access
9 Scopus citations

Sodium thiosulfate for protection from cisplatin-induced hearing loss

Brock, P. R., Maibach, R., Childs, M., Rajput, K., Roebuck, D., Sullivan, M. J., Laithier, V., Ronghe, M., Dall'Igna, P., Hiyama, E., Brichard, B., Skeen, J., Mateos, M. E., Capra, M., Rangaswami, A. A., Ansari, M., Rechnitzer, C., Veal, G. J., Covezzoli, A., Brugières, L. & 4 others, Perilongo, G., Czauderna, P., Morland, B. & Neuwelt, E. A., Jun 21 2018, In : New England Journal of Medicine. 378, 25, p. 2376-2385 10 p.

Research output: Contribution to journalArticle

51 Scopus citations
2017

Comprehensive review of the ThinkFirst injury prevention programs: A 30-Year success story for organized neurosurgery

Youngers, E. H., Zundel, K., Gerhardstein, D., Martínez, M., Bertrán, C., Proctor, M. R., Spatola, M. A. & Neuwelt, E. A., Sep 1 2017, In : Clinical Neurosurgery. 81, 3, p. 416-421 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Current and potential imaging applications of ferumoxytol for magnetic resonance imaging

Toth, G. B., Varallyay, C. G., Horvath, A., Bashir, M. R., Choyke, P. L., Daldrup-Link, H. E., Dosa, E., Finn, J. P., Gahramanov, S., Harisinghani, M., Macdougall, I., Neuwelt, A., Vasanawala, S. S., Ambady, P., Barajas, R., Cetas, J. S., Ciporen, J., DeLoughery, T. J., Doolittle, N. D., Fu, R. & 13 others, Grinstead, J., Guimaraes, A. R., Hamilton, B. E., Li, X., McConnell, H. L., Muldoon, L. L., Nesbit, G., Netto, J. P., Petterson, D., Rooney, W. D., Schwartz, D., Szidonya, L. & Neuwelt, E. A., Jul 2017, In : Kidney International. 92, 1, p. 47-66 20 p.

Research output: Contribution to journalReview article

73 Scopus citations

Dose escalation study of intravenous and intra-arterial N-acetylcysteine for the prevention of oto- and nephrotoxicity of cisplatin with a contrast-induced nephropathy model in patients with renal insufficiency

Dósa, E., Heltai, K., Radovits, T., Molnár, G., Kapocsi, J., Merkely, B., Fu, R., Doolittle, N. D., Tóth, G. B., Urdang, Z. & Neuwelt, E. A., Oct 3 2017, In : Fluids and Barriers of the CNS. 14, 1, 26.

Research output: Contribution to journalArticle

6 Scopus citations

Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431): a multicentre, randomised, controlled, open-label, phase 3 trial

Freyer, D. R., Chen, L., Krailo, M. D., Knight, K., Villaluna, D., Bliss, B., Pollock, B. H., Ramdas, J., Lange, B., Van Hoff, D., VanSoelen, M. L., Wiernikowski, J., Neuwelt, E. A. & Sung, L., Jan 1 2017, In : The Lancet Oncology. 18, 1, p. 63-74 12 p.

Research output: Contribution to journalArticle

50 Scopus citations

Enhancing the cytotoxicity of chemoradiation with radiation-guided delivery of anti-MGMT morpholino oligonucleotides in non-methylated solid tumors

Ambady, P., Wu, Y. J., Walker, J. M., Kersch, C., Pagel, M. A., Woltjer, R. R., Fu, R. R., Muldoon, L. & Neuwelt, E., Aug 1 2017, In : Cancer Gene Therapy. 24, 8, p. 348-357 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Group-Wide, Prospective Study of Ototoxicity Assessment in Children Receiving Cisplatin Chemotherapy (ACCL05C1): A Report From the Children's Oncology Group

Knight, K. R., Chen, L., Freyer, D., Aplenc, R., Bancroft, M., Bliss, B., Dang, H., Gillmeister, B., Hendershot, E., Kraemer, D. F., Lindenfeld, L., Meza, J., Neuwelt, E. A., Pollock, B. H. & Sung, L., Feb 1 2017, In : Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 35, 4, p. 440-445 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

High αv integrin level of cancer cells is associated with development of brain metastasis in athymic rats

Wu, Y. J., Pagel, M. A., Muldoon, L., Fu, R. R. & Neuwelt, E., Aug 1 2017, In : Anticancer Research. 37, 8, p. 4029-4040 12 p.

Research output: Contribution to journalArticle

11 Scopus citations
13 Scopus citations

Pseudo-extravasation rate constant of dynamic susceptibility contrast-MRI determined from pharmacokinetic first principles

Li, X., Varallyay, C. G., Gahramanov, S., Fu, R. R., Rooney, W. & Neuwelt, E., 2017, (Accepted/In press) In : NMR in Biomedicine.

Research output: Contribution to journalArticle

Quantitative comparison of delayed ferumoxytol T1 enhancement with immediate gadoteridol enhancement in high grade gliomas

Horváth, A., Varallyay, C. G., Schwartz, D., Toth, G. B., Netto, J. P., Barajas, R., Várallyay, P., Szidonya, L., Firkins, J., Youngers, E., Fu, R. R., Ambady, P., Bogner, P. & Neuwelt, E., Jan 1 2017, (Accepted/In press) In : Magnetic Resonance in Medicine.

Research output: Contribution to journalArticle

4 Scopus citations

The translational significance of the neurovascular unit

McConnell, H. L., Kersch, C. N., Woltjer, R. R. & Neuwelt, E., Jan 20 2017, In : Journal of Biological Chemistry. 292, 3, p. 762-770 9 p.

Research output: Contribution to journalReview article

75 Scopus citations

What does the boxed warning tell us? Safe practice of using ferumoxytol as an MRI CONTRAST AGENT

Varallyay, C. G., Toth, G. B., Fu, R. R., Netto, J. P., Firkins, J., Ambady, P. & Neuwelt, E., Jul 1 2017, In : American Journal of Neuroradiology. 38, 7, p. 1297-1302 6 p.

Research output: Contribution to journalArticle

21 Scopus citations
2016

Ferumoxytol-enhanced MRI differentiation of meningioma from dural metastases: a pilot study with immunohistochemical observations

Hamilton, B., Woltjer, R. R., Prola-Netto, J., Nesbit, G., Gahramanov, S., Pham, T., Wagner, J. & Neuwelt, E., Jul 8 2016, (Accepted/In press) In : Journal of Neuro-Oncology. p. 1-9 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Ferumoxytol nanoparticle uptake in brain during acute neuroinflammation is cell-specific

McConnell, H. L., Schwartz, D. L., Richardson, B. E., Woltjer, R. R., Muldoon, L. & Neuwelt, E., Aug 1 2016, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 12, 6, p. 1535-1542 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
11 Scopus citations
3 Scopus citations

Outwitting the Blood-Brain Barrier

Neuwelt, E., Ambady, P., Muldoon, L., McConnell, H. & Doolittle, N., Nov 15 2016, In : Oncology (Williston Park, N.Y.). 30, 11

Research output: Contribution to journalArticle

2 Scopus citations

Safety Report of Ferumoxytol for Magnetic Resonance Imaging in Children and Young Adults

Muehe, A. M., Feng, D., Von Eyben, R., Luna-Fineman, S., Link, M. P., Muthig, T., Huddleston, A. E., Neuwelt, E. A. & Daldrup-Link, H. E., Apr 1 2016, In : Investigative Radiology. 51, 4, p. 221-227 7 p.

Research output: Contribution to journalArticle

43 Scopus citations

Therapy for secondary CNS involvement inmalignant lymphomas: No standard yet!

Korfel, A., Chamberlain, M., Neuwelt, E., Thiel, E., Doolittle, N., Schlegel, U., Dreyling, M., Rubenstein, J., Fischer, L., Björkholm, M., Martus, P., Weller, M. & Glantz, M., May 20 2016, In : Journal of Clinical Oncology. 34, 15, p. 1829-1830 2 p.

Research output: Contribution to journalLetter

3 Scopus citations
2015
5 Scopus citations

Interactions between αv-Integrin and HER2 and their role in the invasive phenotype of breast cancer cells in vitro and in rat brain

Lal, S., Kersch, C., Beeson, K. A., Wu, Y. J., Muldoon, L. L. & Neuwelt, E. A., Jul 29 2015, In : PloS one. 10, 7, e0131842.

Research output: Contribution to journalArticle

11 Scopus citations
29 Scopus citations

N-acetylcysteine chemoprotection without decreased cisplatin antitumor efficacy in pediatric tumor models

Muldoon, L. L., Wu, Y. J., Pagel, M. A. & Neuwelt, E. A., Jan 1 2015, In : Journal of Neuro-Oncology. 121, 3, p. 433-440 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Primary CNS lymphoma

Neuwelt, E. A. & Schiff, D., Mar 24 2015, In : Neurology. 84, 12, p. 1194-1195 2 p.

Research output: Contribution to journalEditorial

5 Scopus citations

Unsanctifying the sanctuary: Challenges and opportunities with brain metastases

Puhalla, S., Elmquist, W., Freyer, D., Kleinberg, L., Adkins, C., Lockman, P., McGregor, J., Muldoon, L., Nesbit, G., Peereboom, D., Smith, Q., Walker, S. & Neuwelt, E., May 1 2015, In : Neuro-Oncology. 17, 5, p. 639-651 13 p.

Research output: Contribution to journalReview article

35 Scopus citations
22 Scopus citations
2014

Delivery of chemotherapeutics across the blood-brain barrier: Challenges and advances

Doolittle, N. D., Muldoon, L. L., Culp, A. Y. & Neuwelt, E. A., Jan 1 2014, Advances in Pharmacology. Academic Press Inc., p. 203-243 41 p. (Advances in Pharmacology; vol. 71).

Research output: Chapter in Book/Report/Conference proceedingChapter

39 Scopus citations

Diagnosis of pseudoprogression using MRI perfusion in patients with glioblastoma multiforme may predict improved survival

Gahramanov, S., Varallyay, C., Tyson, R. M. A., Lacy, C., Fu, R., Netto, J. P. R., Nasseri, M., White, T., Woltjer, R. L., Gultekin, S. H. U. & Neuwelt, E. A., Nov 1 2014, In : CNS oncology. 3, 6, p. 389-400 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

Evaluation of pseudoprogression in patients with glioblastoma multiforme using dynamic magnetic resonance imaging with ferumoxytol calls RANO criteria into question

Nasseri, M., Gahramanov, S., Netto, J. P., Fu, R., Muldoon, L. L., Varallyay, C., Hamilton, B. E. & Neuwelt, E. A., Aug 2014, In : Neuro-Oncology. 16, 8, p. 1146-1154 9 p.

Research output: Contribution to journalArticle

56 Scopus citations

Incidence of Pneumocystis jirovecii pneumonia after temozolomide for CNS malignancies without prophylaxis

Neuwelt, A. J., Nguyen, T. M., Fu, R., Bubalo, J., Tyson, R. M. A., Lacy, C., Gahramanov, S., Nasseri, M., Barnes, P. D. & Neuwelt, E. A., Jul 1 2014, In : CNS oncology. 3, 4, p. 267-273 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Preclinical high-dose acetaminophen with N-acetylcysteine rescue enhances the efficacy of cisplatin chemotherapy in atypical teratoid rhabdoid tumors

Neuwelt, A. J., Nguyen, T., Wu, Y. J., Donson, A. M., Vibhakar, R., Venkatamaran, S., Amani, V., Neuwelt, E. A., Rapkin, L. B. & Foreman, N. K., Jan 2014, In : Pediatric Blood and Cancer. 61, 1, p. 120-127 8 p.

Research output: Contribution to journalArticle

8 Scopus citations
2013
1 Scopus citations

Acetaminophen enhances cisplatin- and paclitaxel-mediated cytotoxicity to SKOV3 human ovarian carcinoma

Wu, Y. J. J., Neuwelt, A. J., Muldoon, L. L. & Neuwelt, E. A., Jun 1 2013, In : Anticancer research. 33, 6, p. 2391-2400 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Blood-tumor barrier normalization effects on cytotoxic drug delivery to brain tumors

Pishko, G. L., Nasseri, M., Gahramanov, S., Muldoon, L. L. & Neuwelt, E. A., Dec 1 2013, ASME 2013 Summer Bioengineering Conference, SBC 2013. (ASME 2013 Summer Bioengineering Conference, SBC 2013; vol. 1 A).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Feasibility and potential role of ferumoxytol-enhanced neuroimaging in HIV-associated neurocognitive disorder

Nakamoto, B. K., Shikuma, C. M., Ogata-Arakaki, D., Umaki, T., Neuwelt, E. A., Shiramizu, B. T., Chow, D. C., Parikh, N. I., Kallianpur, K. J. & Hamilton, B. E., Dec 1 2013, In : Journal of neurovirology. 19, 6, p. 601-605 5 p.

Research output: Contribution to journalArticle

5 Scopus citations
63 Scopus citations

Immunologic privilege in the central nervous system and the blood-brain barrier

Muldoon, L. L., Alvarez, J. I., Begley, D. J., Boado, R. J., Del Zoppo, G. J., Doolittle, N. D., Engelhardt, B., Hallenbeck, J. M., Lonser, R. R., Ohlfest, J. R., Prat, A., Scarpa, M., Smeyne, R. J., Drewes, L. R. & Neuwelt, E. A., Jan 1 2013, In : Journal of Cerebral Blood Flow and Metabolism. 33, 1, p. 13-21 9 p.

Research output: Contribution to journalReview article

139 Scopus citations

Inhibition of SUR1 decreases the vascular permeability of cerebral metastases

Thompson, E. M., Pishko, G. L., Muldoon, L. L. & Neuwelt, E. A., May 2013, In : Neoplasia (United States). 15, 5, p. 535-543 9 p.

Research output: Contribution to journalArticle

34 Scopus citations

Long-term cognitive function, neuroimaging, and quality of life in primary CNS lymphoma

Doolittle, N. D., Korfel, A., Lubow, M. A., Schorb, E., Schlegel, U., Rogowski, S., Fu, R., Dósa, E., Illerhaus, G., Kraemer, D. F., Muldoon, L. L., Calabrese, P., Hedrick, N., Tyson, R. M., Jahnke, K., Maron, L. M., Butler, R. W. & Neuwelt, E. A., Jul 2 2013, In : Neurology. 81, 1, p. 84-92 9 p.

Research output: Contribution to journalArticle

74 Scopus citations

Preservation of cognitive function in primary CNS lymphoma survivors a median of 12 years after enhanced chemotherapy delivery

Doolittle, N. D., Dósa, E., Fu, R., Muldoon, L. L., Maron, L. M., Lubow, M. A., Tyson, R. M., Lacy, C. A., Kraemer, D. F., Butler, R. W. & Neuwelt, E. A., Nov 1 2013, In : Journal of Clinical Oncology. 31, 31, p. 4026-4027 2 p.

Research output: Contribution to journalLetter

15 Scopus citations
97 Scopus citations