Find Publications


Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials

Dodean, R. A., Kancharla, P., Li, Y., Melendez, V., Read, L., Bane, C. E., Vesely, B., Kreishman-Deitrick, M., Black, C., Li, Q., Sciotti, R. J., Olmeda, R., Luong, T. L., Gaona, H., Potter, B., Sousa, J., Marcsisin, S., Caridha, D., Xie, L., Vuong, C. & 19 others, Zeng, Q., Zhang, J., Zhang, P., Lin, H., Butler, K., Roncal, N., Gaynor-Ohnstad, L., Leed, S. E., Nolan, C., Huezo, S. J., Rasmussen, S. A., Stephens, M. T., Tan, J. C., Cooper, R. A., Smilkstein, M. J., Pou, S., Winter, R. W., Riscoe, M. & Kelly, J. X., Apr 11 2019, In : Journal of Medicinal Chemistry. 62, 7, p. 3475-3502 28 p.

Research output: Contribution to journalArticle

Plasmodium berghei
Macaca mulatta
Drug therapy
Dizocilpine Maleate
2 Citations (Scopus)

Disentangling the genetics of lean mass

Karasik, D., Zillikens, M. C., Hsu, Y. H., Aghdassi, A., Akesson, K., Amin, N., Barroso, I., Bennett, D. A., Bertram, L., Bochud, M., Borecki, I. B., Broer, L., Buchman, A. S., Byberg, L., Campbell, H., Campos-Obando, N., Cauley, J. A., Cawthon, P. M., Chambers, J. C., Chen, Z. & 137 others, Cho, N. H., Choi, H. J., Chou, W. C., Cummings, S. R., De Groot, L. C. P. G. M., De Jager, P. L., Demuth, I., Diatchenko, L., Econs, M. J., Eiriksdottir, G., Enneman, A. W., Eriksson, J., Eriksson, J. G., Estrada, K., Evans, D. S., Feitosa, M. F., Fu, M., Gieger, C., Grallert, H., Gudnason, V., Lenore, L. J., Hayward, C., Hofman, A., Homuth, G., Huffman, K. M., Husted, L. B., Illig, T., Ingelsson, E., Ittermann, T., Jansson, J. O., Johnson, T., Biffar, R., Jordan, J. M., Jula, A., Karlsson, M., Khaw, K. T., Kilpeläinen, T. O., Klopp, N., Kloth, J. S. L., Koller, D. L., Kooner, J. S., Kraus, W. E., Kritchevsky, S., Kutalik, Z., Kuulasmaa, T., Kuusisto, J., Laakso, M., Lahti, J., Lang, T., Langdahl, B. L., Lerch, M. M., Lewis, J. R., Lill, C., Lind, L., Lindgren, C., Liu, Y., Livshits, G., Ljunggren, Ö., Loos, R. J. F., Lorentzon, M., Luan, JA., Luben, R. N., Malkin, I., McGuigan, F. E., Medina-Gomez, C., Meitinger, T., Melhus, H., Mellström, D., Michaëlsson, K., Mitchell, B. D., Morris, A. P., Mosekilde, L., Nethander, M., Newman, A. B., Oconnell, J. R., Oostra, B. A., Orwoll, E., Palotie, A., Peacock, M., Perola, M., Peters, A., Prince, R. L., Psaty, B. M., Räikkönen, K., Ralston, S. H., Ripatti, S., Rivadeneira, F., Robbins, J. A., Rotter, J. I., Rudan, I., Salomaa, V., Satterfield, S., Schipf, S., Shin, C. S., Smith, A. V., Smith, S. B., Soranzo, N., Spector, T. D., StanÄ Áková, A., Stefansson, K., Steinhagen-Thiessen, E., Stolk, L., Streeten, E. A., Styrkarsdottir, U., Swart, K. M. A., Thompson, P., Thomson, C. A., Thorleifsson, G., Thorsteinsdottir, U., Tikkanen, E., Tranah, G. J., Uitterlinden, A. G., Van Duijn, C. M., Van Schoor, N. M., Vandenput, L., Vollenweider, P., Völzke, H., Wactawski-Wende, J., Walker, M., J Wareham, N., Waterworth, D., Weedon, M. N., Wichmann, H. E., Widen, E., Williams, F. M. K., Wilson, J. F., Wright, N. C., Yerges-Armstrong, L. M., Yu, L., Zhang, W., Zhao, J. H., Zhou, Y., Nielson, C., Harris, T. B., Demissie, S., Kiel, D. P. & Ohlsson, C., Feb 1 2019, In : American Journal of Clinical Nutrition. 109, 2, p. 276-278 3 p.

Research output: Contribution to journalArticle

Single Nucleotide Polymorphism
Genome-Wide Association Study

Disputes of Self-reported Chronic Disease over Time: The Role of Race, Ethnicity, Nativity, and Language of Interview

Quinones, A., Melekin, A., Cigolle, C. T. & Nagel, C., Jan 1 2019, In : Medical care.

Research output: Contribution to journalArticle

Dissent and Disputes
Chronic Disease
Hispanic Americans
1 Citation (Scopus)

Disruption of CUL3-mediated ubiquitination causes proximal tubule injury and kidney fibrosis

Saritas, T., Cuevas, C. A., Ferdaus, M. Z., Kuppe, C., Kramann, R., Moeller, M. J., Floege, J., Singer, J. D. & McCormick, J. J., Dec 1 2019, In : Scientific Reports. 9, 1, 4596.

Research output: Contribution to journalArticle

Open Access
Cullin Proteins
Proximal Kidney Tubule
1 Citation (Scopus)

Disruption of Intestinal Homeostasis and Intestinal Microbiota During Experimental Autoimmune Uveitis

Janowitz, C., Nakamura, Y. K., Metea, C., Gligor, A., Yu, W., Karstens, L., Rosenbaum, J. J., Asquith, M. & Lin, P., Jan 2 2019, In : Investigative ophthalmology & visual science. 60, 1, p. 420-429 10 p.

Research output: Contribution to journalArticle


Disruption of latent HIV in vivo during the clearance of actinic keratosis by ingenol mebutate

Jiang, G., Maverakis, E., Cheng, M. Y., Elsheikh, M. M., Deleage, C., Méndez-Lagares, G., Shimoda, M., Yukl, S. A., Hartigan-O'Connor, D. J., Thompson, G. R., Estes, J., Wong, J. K. & Dandekar, S., Jan 1 2019, In : JCI Insight. 4, 7, e126027.

Research output: Contribution to journalArticle

Open Access
Actinic Keratosis

Distal Ventriculoatrial Shunt Revision in Adult Myelomeningocele Patient Performed via Endovascular Transvenous Approach

Rao, A. J., Teton, Z., Rodriguez, V., Tieu, B. & Raslan, A., Jan 1 2019, In : World Neurosurgery. 121, p. 24-27 4 p.

Research output: Contribution to journalArticle

Ventriculoperitoneal Shunt
Pleural Cavity
Peritoneal Cavity

Distinct Calcium Sources Define Compartmentalized Synaptic Signaling Domains

Fawley, J. A. & Andresen, M., Jan 1 2019, (Accepted/In press) In : Neuroscientist.

Research output: Contribution to journalReview article

Neurotransmitter Agents
Synaptic Transmission
Nervous System

Distinguishing case study as a research method from case reports as a publication type

Alpi, K. & Evans, J. J., Jan 1 2019, In : Journal of the Medical Library Association : JMLA. 107, 1, p. 1-5 5 p.

Research output: Contribution to journalEditorial

Open Access
research method
3 Citations (Scopus)

Distribution of atopic dermatitis lesions in United States adults

Silverberg, J. I., Margolis, D. J., Boguniewicz, M., Fonacier, L., Grayson, M. H., Ong, P. Y., Chiesa Fuxench, Z. C., Simpson, E. & Gelfand, J. M., Jan 1 2019, In : Journal of the European Academy of Dermatology and Venereology.

Research output: Contribution to journalArticle

Atopic Dermatitis
Quality of Life
2 Citations (Scopus)

Distribution of desferrioxamine-B-extractable soluble manganese(III) and particulate MnO2 in the St. Lawrence Estuary, Canada

Jones, M. R., Oldham, V. E., Luther, G. W., Mucci, A. & Tebo, B., Jan 20 2019, In : Marine Chemistry. 208, p. 70-82 13 p.

Research output: Contribution to journalArticle


Divergent HIV-1-directed immune responses generated by systemic and mucosal immunization with replicating single-cycle adenoviruses in rhesus macaques

Matchett, W. E., Anguiano-Zarate, S. S., Nehete, P. N., Shelton, K., Nehete, B. P., Yang, G., Dorta-Estremera, S., Barnette, P., Xiao, P., Byrareddy, S. N., Villinger, F., Hessell, A., Haigwood, N., Sastry, K. J. & Barry, M. A., May 1 2019, In : Journal of virology. 93, 10, e02016-18.

Research output: Contribution to journalArticle

Human immunodeficiency virus 1
Macaca mulatta

Diverticulitis in the immunocompromised patient

V. Siddharthan, R., Gardner, I. H. & Lu, K., Jan 1 2019, (Accepted/In press) In : Seminars in Colon and Rectal Surgery. 100689.

Research output: Contribution to journalArticle

Immunocompromised Host
1 Citation (Scopus)

DNA repair fidelity in stem cell maintenance, health, and disease

Mani, C., Reddy, P. H. & Palle, K., Jan 1 2019, In : Biochimica et Biophysica Acta - Molecular Basis of Disease.

Research output: Contribution to journalReview article

DNA Repair
Stem Cells
DNA Damage
1 Citation (Scopus)

Does a transition to accountable care in Medicaid shift the modality of colorectal cancer testing?

Davis, M., Shafer, P., Renfro, S., Hassmiller Lich, K., Shannon, J. J., Coronado, G. D., McConnell, K. J. & Wheeler, S. B., Jan 21 2019, In : BMC Health Services Research. 19, 1, 1 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Early Detection of Cancer
Accountable Care Organizations

Does cannabis legalisation change healthcare utilisation? A population-based study using the healthcare cost and utilisation project in Colorado, USA

Delling, F. N., Vittinghoff, E., Dewland, T., Pletcher, M. J., Olgin, J. E., Nah, G., Aschbacher, K., Fang, C. D., Lee, E. S., Fan, S. M., Kazi, D. S. & Marcus, G. M., May 1 2019, In : BMJ open. 9, 5, e027432.

Research output: Contribution to journalArticle

Open Access
Health Care Costs
Delivery of Health Care
Odds Ratio

Does Ownership Make a Difference in Primary Care Practice?

Lindner, S., Solberg, L. I., Miller, W. L., Balasubramanian, B. A., Marino, M., McConnell, K. J., Edwards, S., Stange, K. C., Springer, R. J. & Cohen, D., May 1 2019, In : Journal of the American Board of Family Medicine : JABFM. 32, 3, p. 398-407 10 p.

Research output: Contribution to journalArticle

Open Access
Quality Improvement
Primary Health Care
Process Assessment (Health Care)

Does sentinel lymph node status have prognostic significance in patients with acral lentiginous melanoma?

Pavri, S. N., Han, G., Khan, S. & Han, D., Jun 15 2019, In : Journal of surgical oncology. 119, 8, p. 1060-1069 10 p.

Research output: Contribution to journalArticle

Sentinel Lymph Node Biopsy
Neoplasm Metastasis

Does vaping cause seizures? The need for comprehensive drug testing

Hughes, A. & Hendrickson, R., Jan 1 2019, In : Clinical Toxicology.

Research output: Contribution to journalLetter

Pharmaceutical Preparations

Do High-sensitivity Troponin and Natriuretic Peptide Predict Death or Serious Cardiac Outcomes After Syncope?

Clark, C. L., Gibson, T. A., Weiss, R. E., Yagapen, A. N., Malveau, S. E., Adler, D. H., Bastani, A., Baugh, C. W., Caterino, J. M., Diercks, D. B., Hollander, J. E., Nicks, B. A., Nishijima, D. K., Shah, M. N., Stiffler, K. A., Storrow, A. B., Wilber, S. T. & Sun, B., Jan 1 2019, In : Academic Emergency Medicine.

Research output: Contribution to journalArticle

Natriuretic Peptides
Hospital Emergency Service
Confidence Intervals

Do i Have Calciphylaxis?

Keller, J. J. & Ortega Loayza, A., Jan 1 2019, In : JAMA Dermatology.

Research output: Contribution to journalComment/debate

2 Citations (Scopus)

Dopamine Modulation of Prefrontal Cortex Activity Is Manifold and Operates at Multiple Temporal and Spatial Scales

Lohani, S., Martig, A. K., Deisseroth, K., Witten, I. B. & Moghaddam, B., Apr 2 2019, In : Cell Reports. 27, 1, p. 99-114.e6

Research output: Contribution to journalArticle

Open Access
Prefrontal Cortex
Dopaminergic Neurons

Do prelicensure nursing students' backgrounds impact what they notice and interpret about patients?

Lasater, K., Holloway, K., Lapkin, S., Kelly, M., McGrath, B., Nielsen, A., Stoyles, S., Dieckmann, N. & Campbell, M., Jul 1 2019, In : Nurse education today. 78, p. 37-43 7 p.

Research output: Contribution to journalArticle

Nursing Students

Dose-dependent effects of chronic alcohol drinking on peripheral immune responses

Sureshchandra, S., Raus, A., Jankeel, A., Ligh, B. J. K., Walter, N. A. R., Newman, N., Grant, K. K. & Messaoudi, I., Dec 1 2019, In : Scientific Reports. 9, 1, 7847.

Research output: Contribution to journalArticle

Open Access
Alcohol Drinking
Blood Cells
Self Administration
Macaca mulatta
Virus Integration
Oxidative Phosphorylation
Cardiac Myocytes
1 Citation (Scopus)
Open Access
Expert Testimony
Positron-Emission Tomography
Prostatic Neoplasms
Radiation Oncology

Drug potency on inhibiting late Na+ current is sensitive to gating modifier and current region where drug effects were measured

Wu, M., Tran, P. N., Sheng, J., Randolph, A. L. & Wu, W., Nov 1 2019, In : Journal of Pharmacological and Toxicological Methods. 100, 106605.

Research output: Contribution to journalArticle

Open Access
Pharmaceutical Preparations
Clamping devices
Substance-Related Disorders
Pharmaceutical Preparations
Opioid Analgesics

Dual versus triple antithrombotic therapy in patients undergoing percutaneous coronary intervention-meta-analysis and meta-regression

Agarwal, N., Mahmoud, A. N., Mojadidi, M. K., Golwala, H. & Elgendy, I. Y., Jan 1 2019, In : Cardiovascular Revascularization Medicine.

Research output: Contribution to journalArticle

Percutaneous Coronary Intervention
5 Citations (Scopus)

Dupilumab does not affect correlates of vaccine-induced immunity: A randomized, placebo-controlled trial in adults with moderate-to-severe atopic dermatitis

Blauvelt, A., Simpson, E., Tyring, S. K., Purcell, L. A., Shumel, B., Petro, C. D., Akinlade, B., Gadkari, A., Eckert, L., Graham, N. M. H., Pirozzi, G. & Evans, R., Jan 1 2019, In : Journal of the American Academy of Dermatology. 80, 1, p. 158-167.e1

Research output: Contribution to journalArticle

Atopic Dermatitis
Randomized Controlled Trials

Dupilumab improves patient-reported symptoms of atopic dermatitis, symptoms of anxiety and depression, and health-related quality of life in moderate-to-severe atopic dermatitis: analysis of pooled data from the randomized trials SOLO 1 and SOLO 2

Cork, M. J., Eckert, L., Simpson, E., Armstrong, A., Barbarot, S., Puig, L., Girolomoni, G., de Bruin-Weller, M., Wollenberg, A., Kataoka, Y., Remitz, A., Beissert, S., Mastey, V., Ardeleanu, M., Chen, Z., Gadkari, A. & Chao, J., Jan 1 2019, In : Journal of Dermatological Treatment.

Research output: Contribution to journalArticle

Open Access
Atopic Dermatitis
Quality of Life
3 Citations (Scopus)

Dupilumab provides important clinical benefits to patients with atopic dermatitis who do not achieve clear or almost clear skin according to the Investigator's Global Assessment: a pooled analysis of data from two phase III trials

Silverberg, J. I., Simpson, E., Ardeleanu, M., Thaçi, D., Barbarot, S., Bagel, J., Chen, Z., Eckert, L., Chao, J., Korotzer, A., Rizova, E., Rossi, A. B., Lu, Y., Graham, N. M. H., Hultsch, T., Pirozzi, G. & Akinlade, B., Jul 1 2019, In : British Journal of Dermatology. 181, 1, p. 80-87 8 p.

Research output: Contribution to journalArticle

Open Access
Atopic Dermatitis
Research Personnel
1 Citation (Scopus)
Carotid Endarterectomy
Carotid Arteries
Proportional Hazards Models

Dynamic assembly of ribbon synapses and circuit maintenance in a vertebrate sensory system

Okawa, H., Yu, W. Q., Matti, U., Schwarz, K., Odermatt, B., Zhong, H., Tsukamoto, Y., Lagnado, L., Rieke, F., Schmitz, F. & Wong, R. O. L., Dec 1 2019, In : Nature communications. 10, 1, 2167.

Research output: Contribution to journalArticle

Open Access

Dynamic clonal remodelling in breast cancer metastases is associated with subtype conversion

Lluch, A., González-Angulo, A. M., Casadevall, D., Eterovic, A. K., Martínez de Dueñas, E., Zheng, X., Guerrero-Zotano, Á., Liu, S., Pérez, R., Chen, K., Chacón, J. I., Mills, G., Antolín, S., Blancas, I., López-Serra, P., Carrasco, E., Caballero, R., Prat, A., Rojo, F., Gonzalez-Perez, A. & 2 others, Meric-Bernstam, F. & Albanell, J., Oct 1 2019, In : European Journal of Cancer. 120, p. 54-64 11 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasm Metastasis
Epidermal Growth Factor

Dysregulation of Myosin Complex and Striated Muscle Contraction Pathway in the Brains of ALS-SOD1 Model Mice

Xu, B., Zheng, C., Chen, X., Zhang, Z., Liu, J., Spencer, P. & Yang, X., May 15 2019, In : ACS Chemical Neuroscience. 10, 5, p. 2408-2417 10 p.

Research output: Contribution to journalArticle

Striated Muscle
Amyotrophic Lateral Sclerosis
Muscle Contraction
Superoxide Dismutase
4 Citations (Scopus)

Dystroglycan is a scaffold for extracellular axon guidance decisions

Lindenmaier, L. B., Parmentier, N., Guo, C., Tissir, F. & Wright, K., Feb 13 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Extracellular Matrix Proteins
2 Citations (Scopus)

EAP1 regulation of GnRH promoter activity is important for human pubertal timing

Mancini, A., Howard, S. R., Cabrera, C. P., Barnes, M. R., David, A., Wehkalampi, K., Heger, S., Lomniczi, A., Guasti, L., Ojeda, S. & Dunkel, L., Apr 15 2019, In : Human molecular genetics. 28, 8, p. 1357-1368 12 p.

Research output: Contribution to journalArticle

Open Access
Gonadotropin-Releasing Hormone
Delayed Puberty

Earlier identification of seriously ill patients: An implementation case series

Lakin, J. R., Desai, M., Engelman, K., O'Connor, N., Teuteberg, W. G., Coackley, A., Kilpatrick, L. B., Gawande, A. & Fromme, E., Jan 1 2019, In : BMJ Supportive and Palliative Care.

Research output: Contribution to journalArticle

Patient Selection
Palliative Care
Delivery of Health Care
Practice Guidelines
Open Access
Blood Platelets
Confidence Intervals
Interventional Radiology
Hippocampal Mossy Fibers
Temporal Lobe Epilepsy
Presynaptic Terminals

Early Diagnosis and Management of Aggressive Posterior Vitreoretinopathy Presenting in Premature Neonates

Gupta, M. P., Yonekawa, Y., Campbell, J., Rusu, I., Zahid, S., Patel, S. N., Chau, F., Jonas, K. E., Oltra, E., Orlin, A., Chang, J., Horowitz, J., Abramson, D. H., Marr, B., Capone, A. & Paul Chan, R. V., Apr 1 2019, In : Ophthalmic surgery, lasers & imaging retina. 50, 4, p. 201-207 7 p.

Research output: Contribution to journalArticle

Retinal Detachment
Early Diagnosis
Newborn Infant

Early-life sleep disruption increases parvalbumin in primary somatosensory cortex and impairs social bonding in prairie voles

Jones, C. E., Opel, R. A., Kaiser, M. E., Chau, A. Q., Quintana, J. R., Nipper, M. A., Finn, D. D., Hammock, E. A. D. & Lim, M., Jan 30 2019, In : Science advances. 5, 1, eaav5188.

Research output: Contribution to journalArticle

Somatosensory Cortex
REM Sleep
8 Citations (Scopus)

Early neuromuscular blockade in the acute respiratory distress syndrome

National Heart, Lung, and Blood Institute PETAL Clinical Trials Network, May 23 2019, In : New England Journal of Medicine. 380, 21, p. 1997-2008 12 p.

Research output: Contribution to journalArticle

Neuromuscular Blockade
Adult Respiratory Distress Syndrome
Severe Acute Respiratory Syndrome
Positive-Pressure Respiration
Control Groups

Early Optic Nerve Head Glial Proliferation and Jak-Stat Pathway Activation in Chronic Experimental Glaucoma

Lozano, D. C., Choe, T. E., Cepurna, W. O., Morrison, J. & Johnson, E., Mar 1 2019, In : Investigative ophthalmology & visual science. 60, 4, p. 921-932 12 p.

Research output: Contribution to journalArticle

Open Access
Optic Disk
Wounds and Injuries

Early overnutrition alters synaptic signaling and induces leptin resistance in arcuate proopiomelanocortin neurons

Roberts, B. L., Bennett, C. M., Carroll, J. M., Lindsley, S. R. & Kievit, P., Jul 1 2019, In : Physiology and Behavior. 206, p. 166-174 9 p.

Research output: Contribution to journalArticle

Arcuate Nucleus of Hypothalamus
1 Citation (Scopus)

Early Prediction of Breast Cancer Therapy Response using Multiresolution Fractal Analysis of DCE-MRI Parametric Maps

Machireddy, A., Thibault, G., Tudorica, L. A., Afzal, A., Mishal, M., Kemmer, K., Naik, A., Troxell, M., Goranson, E., Oh, K., Roy, N., Jafarian, N., Holtorf, M., Huang, W. & Song, X., Mar 1 2019, In : Tomography (Ann Arbor, Mich.). 5, 1, p. 90-98 9 p.

Research output: Contribution to journalArticle

Open Access
Magnetic Resonance Imaging
Breast Neoplasms
Drug Therapy
Area Under Curve

Early subspecialization in orthopedic surgery training

Mason DePasse, J., Nzeogu, M. I., Travers, C., Mulcahey, M. K., Palumbo, M. A., Hart, R., Lawrence Marsh, J. & Daniels, A. H., Jan 1 2019, In : Orthopedics. 42, 1, p. e39-e43

Research output: Contribution to journalArticle

Internship and Residency
Sports Medicine